Protein Alignment Pax8 and Poxn

DIOPT Version :10

• Sequence 1: NP_035170.1
• Gene: Pax8 / 18510
• MGIID: 97492
• Length: 457
• Species: Mus musculus
• Sequence 2: NP_476686.1
• Gene: Poxn / 36741
• FlyBaseID: FBgn0003130
• Length: 425
• Species: Drosophila melanogaster
• Alignment Length: 521
• Identity: 161/521 - (30%)
• Similarity: 205/521 - (39%)
• Gaps: 195/521 - (37%)

Mouse     1 MPHNSIRSGHGGLNQLGGAFVNGRPLPEVVRQRIVDLAHQGVRPCDISRQLRVSHGCVSKILGRY 65
            |||    :|..|:|||||.||||||||:.||:||||||..|||||||||||.||||||||||.|:
  Fly     1 MPH----TGQAGVNQLGGVFVNGRPLPDCVRRRIVDLALCGVRPCDISRQLLVSHGCVSKILTRF 61

Mouse    66 YETGSIRPGVIGGSKPK-VATPKVVEKIGDYKRQNPTMFAWEIRDRLLAEGVCDNDTVPSVSSIN 129
            |||||||||.|||||.| ||||.||:||...|.:|..|||||||::|..:.|||..:|||:||||
  Fly    62 YETGSIRPGSIGGSKTKQVATPTVVKKIIRLKEENSGMFAWEIREQLQQQRVCDPSSVPSISSIN 126

Mouse   130 RIIR---------TKVQQ-------------------------------PFNLPMDSCVATKSLS 154
            ||:|         |..||                               |..:...:..||.|::
  Fly   127 RILRNSGLWTDEMTSSQQNAAAAAAAAAAAAHQAGSGPSNGYGGQAPPPPVTVAPPTPAATPSIA 191

Mouse   155 ----PGHTLIPSSAVTP----PESPQSDSLGSTYSINGLLGIAQPGNDNKRKMDDSDQDSCRLSI 211
                |...::.|:...|    |:.|.|...|.::.:          |.|...:|
  Fly   192 RYAKPPALMMNSAGEMPIKPAPKMPPSMGHGHSHGL----------NPNVSGLD----------- 235

Mouse   212 DSQSSSSGPRKHLRTDT----FSQHHLEALEC-------PFERQHYPEAYASPSHTKGEQGLYPL 265
               .|.|...||...:.    ::|.|::|...       |:...:.|.|.|
  Fly   236 ---LSYSALHKHWLWNPSLLYYTQAHIQAQAAASGGQFLPYAGGYLPHAMA-------------- 283

Mouse   266 PLLNSALDDGKATLTSSNTPLGRNLSTHQTYPVVADPHSPFAIKQETPELSSSSSTPSSLSSSAF 330
                       |...||.:.||....:..:    .|..:|.|......:..|..|:|::||.:|
  Fly   284 -----------AAAASSTSALGGFTKSESS----IDLSTPGAAGDALSDCDSGKSSPAALSLTA- 332

Mouse   331 LDLQQVGSGGPAGASVPPFNAFPHAASVYGQFTGQALLSGREMVGPTLPGYPPHIPTSGQGSYAS 395
                   |||..||...| .|.|
  Fly   333 -------SGGGNGAGSAP-EASP------------------------------------------ 347

Mouse   396 SAIAGMVAGSEYSGNAYSHT----PYSSYSEAWRFPNSSL---------LSSPYYYSSTSRPSAP 447
                         |:..||:    || |..|..:.|...|         |.|....||...|.||
  Fly   348 -------------GSTLSHSRKRNPY-SIEELLKKPEKRLRLDSNRLECLESSSCESSQDSPVAP 398

Mouse   448 P 448
            |
  Fly   399 P 399

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pax8	NP_035170.1	PAX	9..133	CDD:128645	90/124 (73%)
		PAI subdomain. /evidence=ECO:0000255|PROSITE-ProRule:PRU00381	12..68		45/55 (82%)
		RED subdomain. /evidence=ECO:0000255|PROSITE-ProRule:PRU00381	87..135		27/56 (48%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	159..224		12/68 (18%)
		Pax2_C	344..456	CDD:463563	21/118 (18%)
Poxn	NP_476686.1	HTH_ARSR	5..133	CDD:481197	91/127 (72%)