DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pax5 and al

DIOPT Version :9

Sequence 1:	NP_032808.1	Gene:	Pax5 / 18507	MGIID:	97489	Length:	391	Species:	Mus musculus
Sequence 2:	NP_722629.1	Gene:	al / 33208	FlyBaseID:	FBgn0000061	Length:	408	Species:	Drosophila melanogaster

Alignment Length:	322	Identity:	80/322 - (24%)
Similarity:	120/322 - (37%)	Gaps:	107/322 - (33%)

- Green bases have known domain annotations that are detailed below.

Mouse   142 KVQQPPNQPVPASSHSIVSTGSVTQVSSVSTDSAGSSYSISGILGITSPSADTNKRKRDEGIQES 206
            |:::.|.:...|...::|   .|.:....|..|||::.::|..:...:||..:..    .|...|
  Fly     8 KLEELPQEAKLAHPDAVV---LVDRAPGSSAASAGAALTVSMSVSGGAPSGASGA----SGGTNS 65

Mouse   207 PVPNGHSLPGRDFL---RKQMR-GDLFTQQQLEVLDRVFERQHYSDIFT---------------- 251
            ||.:|:|....|..   |||.| ...||..|||.|::.|.|.||.|:||
  Fly    66 PVSDGNSDCEADEYAPKRKQRRYRTTFTSFQLEELEKAFSRTHYPDVFTREELAMKIGLTEARIQ 130

Mouse   252 -----------TTEPIKPEQTTEYSAMASLAGGLDDMKANLTSPTPAD----IGSSVPGPQS--- 298
                       ..|.:.| |:..|:..  |.||...|:..:.:..|.:    :|..:..|..
  Fly   131 VWFQNRRAKWRKQEKVGP-QSHPYNPY--LPGGAATMQTVVGAALPPNPFTHLGFQLRKPFDAQH 192

Mouse   299 --------YPIVTGRDLASTTLP-GY-------PPHVPPAGQ-GSYSAPTLTGMVPGSEFS---- 342
                    ||.::    |:..:| ||       |||:.|.|. |.||        |.|.|.
  Fly   193 AANLAAFRYPHLS----AAPMIPSGYFNQFQRAPPHMLPHGMAGMYS--------PSSSFQSLLA 245

Mouse   343 -------GSPYSHPQYSSYNDSWRFPNPGLL-GSPYYYSPAARGAAPPAA-----ATAYDRH 391
                   |:|...|             |.|| |||..:||....|:||.:     |:.:.:|
  Fly   246 NMTAVPRGTPLGKP-------------PALLVGSPDLHSPNHMLASPPTSPASGHASQHQQH 294

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pax5	NP_032808.1	PAX	16..140	CDD:128645
		PAI subdomain. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00381	19..75
		RED subdomain. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00381	94..142		80/322 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	182..218		9/35 (26%)
		Pax2_C	285..389	CDD:289189	35/144 (24%)
al	NP_722629.1	Homeobox	89..141	CDD:278475	13/51 (25%)
al	NP_722629.1	OAR	374..391	CDD:281777
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910