DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pax4 and al

DIOPT Version :9

Sequence 1:	NP_035168.1	Gene:	Pax4 / 18506	MGIID:	97488	Length:	349	Species:	Mus musculus
Sequence 2:	NP_722629.1	Gene:	al / 33208	FlyBaseID:	FBgn0000061	Length:	408	Species:	Drosophila melanogaster

Alignment Length:	223	Identity:	66/223 - (29%)
Similarity:	90/223 - (40%)	Gaps:	36/223 - (16%)

- Green bases have known domain annotations that are detailed below.

Mouse   156 HSNCGAPRGPHPGTSHRNRTIFSPGQAEALEKEFQRGQYPDSVARGKLAAATSLPEDTVRVWFSN 220
            :|:|.|..........|.||.|:..|.|.|||.|.|..|||...|.:||....|.|..::|||.|
  Fly    71 NSDCEADEYAPKRKQRRYRTTFTSFQLEELEKAFSRTHYPDVFTREELAMKIGLTEARIQVWFQN 135

Mouse   221 RRAKWRRQEKL-----KWEAQLPGASQDL------TVPKNSPGIISAQ-------QSPGSVPSAA 267
            ||||||:|||:     .:...|||.:..:      .:|.|....:..|       |...::.:..
  Fly   136 RRAKWRKQEKVGPQSHPYNPYLPGGAATMQTVVGAALPPNPFTHLGFQLRKPFDAQHAANLAAFR 200

Mouse   268 LPVLE--PLSPS--FCQLCCGTAP---------GRCSSDTSSQAYLQPYWDCQSLLPVASSSYVE 319
            .|.|.  |:.||  |.|.  ..||         |..|..:|.|:.|..........|:.....:.
  Fly   201 YPHLSAAPMIPSGYFNQF--QRAPPHMLPHGMAGMYSPSSSFQSLLANMTAVPRGTPLGKPPALL 263

Mouse   320 FAWPCLTTHPVHHLIGGPGQVP-STHCS 346
            ...|.|  |..:|::..|...| |.|.|
  Fly   264 VGSPDL--HSPNHMLASPPTSPASGHAS 289

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pax4	NP_035168.1	PAX	5..129	CDD:128645
		PAI subdomain. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00381	8..64
		RED subdomain. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00381	83..131
		Homeobox	174..226	CDD:278475	26/51 (51%)
		Transcription repression	278..349		19/79 (24%)
al	NP_722629.1	Homeobox	89..141	CDD:278475	26/51 (51%)
al	NP_722629.1	OAR	374..391	CDD:281777
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910