DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DUSP7 and puc

DIOPT Version :9

Sequence 1:	NP_001938.2	Gene:	DUSP7 / 1849	HGNCID:	3073	Length:	419	Species:	Homo sapiens
Sequence 2:	NP_524273.1	Gene:	puc / 40958	FlyBaseID:	FBgn0243512	Length:	476	Species:	Drosophila melanogaster

Alignment Length:	269	Identity:	91/269 - (33%)
Similarity:	133/269 - (49%)	Gaps:	40/269 - (14%)

- Green bases have known domain annotations that are detailed below.

Human   149 APASVLGLLLQKLRDDGCQAYYLQGGFNKFQTEY-SEHCETNVDSSSSPSSSPPTSVLGLGGLRI 212
            ||..:|.:.:|...::.      :.|.|  |.:| ::....|:......|::..::.:..||
  Fly    59 APCLLLFMPIQNTNNNN------RIGAN--QKDYPNKRSRENLACDEVTSTTSSSTAMNGGG--- 112

Human   213 SSDCSDGESDRELPSSATESDGSPVP---SSQPAFPVQILPYLYLGCAKDSTNLDVLGKYGIKYI 274
                       ..| :.|.|..||..   .:.||.||  .|:|.||..:|:   |.....|...:
  Fly   113 -----------RTP-ALTRSCSSPAVYDIETHPASPV--FPHLLLGNGRDA---DDPSSVGANCV 160

Human   275 LNVTPNLPNAFEHGGEFTYKQIPISDHWSQNLSQFFPEAISFIDEARSKKCGVLVHCLAGISRSV 339
            ||||...||. .|.....|.|||.||...||:.|:|.||..||::||.....||:||.||||||.
  Fly   161 LNVTCQSPNE-SHLQGLKYMQIPASDTPHQNIKQYFQEAYDFIEDARKTGSRVLLHCHAGISRSA 224

Human   340 TVTVAYLMQKMNLSLNDAYDFVKRKKSNISPNFNFMGQLLDFERTL---GLSSPCDNHASSEQLY 401
            |:.:||:|:..:|||.:||..||..:..||||.|||||||:.|:.|   |:.:|...|.:|.
  Fly   225 TIAIAYVMRYKSLSLLEAYKLVKVARPIISPNLNFMGQLLELEQNLRKSGVLAPATPHLNSP--- 286

Human   402 FSTPTNHNL 410
             |.|::.::
  Fly   287 -SNPSSSSV 294

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DUSP7	NP_001938.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..47
		DSP_MapKP	55..186	CDD:238723	8/37 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	216..240		5/26 (19%)
		DSP_DUSP7	240..388	CDD:350491	69/150 (46%)
		Substrate binding. /evidence=ECO:0000269\|PubMed:26057789, ECO:0007744\|PDB:4Y2E	331..337		4/5 (80%)
puc	NP_524273.1	DSPc	133..267	CDD:238073	66/139 (47%)
puc	NP_524273.1	CDC14	<193..272	CDD:225297	42/78 (54%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2281
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.940