DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DUSP7 and Mkp3

DIOPT Version :9

Sequence 1:	NP_001938.2	Gene:	DUSP7 / 1849	HGNCID:	3073	Length:	419	Species:	Homo sapiens
Sequence 2:	NP_001262031.1	Gene:	Mkp3 / 40081	FlyBaseID:	FBgn0036844	Length:	497	Species:	Drosophila melanogaster

Alignment Length:	359	Identity:	152/359 - (42%)
Similarity:	208/359 - (57%)	Gaps:	37/359 - (10%)

- Green bases have known domain annotations that are detailed below.

Human    56 SAEWLQEELEARGGASLLLLDCRPHELFESSHIETAINLAIPGLMLRRLRKGNLPIRSIIPNHAD 120
            |.||||.:|.:.....|:|||||....:..|||..|:||.||.::||||..|.:.:.|.|.:...
  Fly    10 SKEWLQSQLRSLDSKDLILLDCRGSHEYSESHIRGAVNLCIPSIVLRRLAVGKIDLASTIKSPEL 74

Human   121 KERFATRCKAATVLLYDEATAEWQPEPGAPA--------SVLGLLLQKLRDDGCQAYYLQGGFNK 177
            |:|..:..|....:||:......|.:..|.|        |::.:|.::|:.|||:...||.|||.
  Fly    75 KQRIQSGYKLCWFILYNGEGVPGQNQEIAGAGSLAVAMDSIISILHRRLKQDGCRVVALQDGFNN 139

Human   178 FQTEYSEHCETN-------VDSSSSPSSSPPTSVLGLGGLRISSDCSDGESDRELPSSATESDGS 235
            |:..:.|.||.:       ::||.:..:.   .::||..||||:.    :||....|||..||
  Fly   140 FRQAFPEWCEDDNQTHSKEIESSRNVQTD---QLMGLRSLRISTT----QSDSACSSSAESSD-- 195

Human   236 PVPSSQ-----------PAFPVQILP-YLYLGCAKDSTNLDVLGKYGIKYILNVTPNLPNAFEHG 288
             ..||.           ...||:|:| .|:||.|..|.:.:.|.||.|||:|||||:|||.|:..
  Fly   196 -CESSSHHHHHHSHHNYNEAPVEIIPGLLFLGNATHSCDSEALKKYNIKYVLNVTPDLPNKFKES 259

Human   289 GEFTYKQIPISDHWSQNLSQFFPEAISFIDEARSKKCGVLVHCLAGISRSVTVTVAYLMQKMNLS 353
            |:..|.||||:||:||:|:..||:||.||:||||....||||||||:|||||||:||||....||
  Fly   260 GDIKYLQIPITDHYSQDLAIHFPDAIQFIEEARSASSVVLVHCLAGVSRSVTVTLAYLMHTRGLS 324

Human   354 LNDAYDFVKRKKSNISPNFNFMGQLLDFERTLGL 387
            ||||:..|:.:|.::||||:||.|||.||..|.|
  Fly   325 LNDAFAMVRDRKPDVSPNFHFMQQLLSFESQLRL 358

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DUSP7	NP_001938.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..47
		DSP_MapKP	55..186	CDD:238723	48/137 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	216..240		7/23 (30%)
		DSP_DUSP7	240..388	CDD:350491	86/160 (54%)
		Substrate binding. /evidence=ECO:0000269\|PubMed:26057789, ECO:0007744\|PDB:4Y2E	331..337		4/5 (80%)
Mkp3	NP_001262031.1	DSP_MapKP	8..148	CDD:238723	48/137 (35%)
		DSPc	215..353	CDD:238073	81/137 (59%)
		CDC14	<242..359	CDD:225297	73/117 (62%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	161	1.000	Domainoid score	I4012
eggNOG	1	0.900	-	-		E2759_KOG1717
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1468
Inparanoid	1	1.050	253	1.000	Inparanoid score	I3206
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52370
OrthoDB	1	1.010	-	-		D389486at33208
OrthoFinder	1	1.000	-	-		FOG0002164
OrthoInspector	1	1.000	-	-		otm42048
orthoMCL	1	0.900	-	-		OOG6_107960
Panther	1	1.100	-	-	LDO	PTHR10159
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2281
SonicParanoid	1	1.000	-	-		X468
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.870