DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DUSP7 and CG10089

DIOPT Version :9

Sequence 1:	NP_001938.2	Gene:	DUSP7 / 1849	HGNCID:	3073	Length:	419	Species:	Homo sapiens
Sequence 2:	NP_001261803.1	Gene:	CG10089 / 39517	FlyBaseID:	FBgn0036369	Length:	447	Species:	Drosophila melanogaster

Alignment Length:	141	Identity:	54/141 - (38%)
Similarity:	83/141 - (58%)	Gaps:	11/141 - (7%)

- Green bases have known domain annotations that are detailed below.

Human   247 QILPYLYLGCAKDSTNLDVLGKYGIKYILNV--TPN--LPNAFEHGGEFTYKQIPISDHWSQNLS 307
            ::||.||:|..:||.:...|.::.|.:|:.:  :|.  ||:  :|     |..:..||...||||
  Fly     7 KVLPGLYVGNYRDSKDHAQLERFKISHIIAIHDSPRRLLPD--KH-----YLCVMASDTPDQNLS 64

Human   308 QFFPEAISFIDEARSKKCGVLVHCLAGISRSVTVTVAYLMQKMNLSLNDAYDFVKRKKSNISPNF 372
            |:|.....||..||.::..||:|||||:||||||.|||:|...:|:..:|...|:..::..:||.
  Fly    65 QYFSVCNDFIHAARLREGNVLIHCLAGMSRSVTVAVAYIMTATHLNWKEALKVVRAGRAVANPNA 129

Human   373 NFMGQLLDFER 383
            .|..||.:||:
  Fly   130 GFQSQLQEFEQ 140

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DUSP7	NP_001938.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..47
		DSP_MapKP	55..186	CDD:238723
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	216..240
		DSP_DUSP7	240..388	CDD:350491	54/141 (38%)
		Substrate binding. /evidence=ECO:0000269\|PubMed:26057789, ECO:0007744\|PDB:4Y2E	331..337		4/5 (80%)
CG10089	NP_001261803.1	DSPc	4..139	CDD:238073	52/138 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910