DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cntn3 and Cont

DIOPT Version :9

Sequence 1:	NP_032805.2	Gene:	Cntn3 / 18488	MGIID:	99534	Length:	1028	Species:	Mus musculus
Sequence 2:	NP_649461.2	Gene:	Cont / 40553	FlyBaseID:	FBgn0037240	Length:	1390	Species:	Drosophila melanogaster

Alignment Length:	1015	Identity:	324/1015 - (31%)
Similarity:	484/1015 - (47%)	Gaps:	72/1015 - (7%)

- Green bases have known domain annotations that are detailed below.

Mouse    20 ELLLQGPVFIKEPSNSIFPVDSED--KKITLNCEARGNPSPHYRW--------QLNGSDIDTSLD 74
            |.:.:||.|:|:|:::.|.|:...  ..:||:|.|.|.|:|.|.|        :|....||....
  Fly   356 ERIPRGPYFVKQPNDTTFDVNKNRLINDVTLSCLANGYPTPSYTWYREVYVDDRLEYQKIDPLAQ 420

Mouse    75 HRYKLNGGNLIVINPNRNWDTGSYQCFATNSLGTIVSREAKLQFAYLENFKTRMRSTVSVREGQG 139
            .||.::|||||:..|.:..|.|:|.|.|.|..|.|.|..|.|.|.::..|..: ||..:.....|
  Fly   421 DRYTISGGNLIIYEPKQALDQGAYHCVAENKFGRIRSESAHLNFGFIMEFNLK-RSAETSEMNWG 484

Mouse   140 VVLLCGPPPHSGELSYAWVFNEYPSFVEEDSRRFVSQETGHLYIAKVEPSDVGNYTCVVTSTVTN 204
            ..:.|.||.|..::.|.|..:.:|:|||||.|.|||:: |.||.:.:|..|..||:|.|.:.|::
  Fly   485 KSIFCDPPQHYPDVRYYWARDYFPNFVEEDQRVFVSRD-GALYFSFIETVDRANYSCTVQTLVSD 548

Mouse   205 TRVLGSPTPLVLRSDG-----VMGEYEPKIEVQFPETLPAAKGSTVRLECFALGNPVPQINWRRS 264
            |...|...||.:..:.     :.....||:   |||. |.| |..:||||.|.|.|:|..||.|
  Fly   549 TGRNGPFFPLRVTPNSNYQALIFANTFPKV---FPEA-PVA-GDEIRLECMAFGYPIPSYNWTR- 607

Mouse   265 DGMPFPNKIKLRKFNGMLEIQNFQQEDTGSYECIAENSRGKNVARGRLTYYAKPYWLQLLRDVEI 329
            .|:|.........:..:|.|||....|.|.|.|...|.|...:....:....:|.:...|:|:..
  Fly   608 QGLPLQRNAYTINYGRVLIIQNATTNDNGEYSCTITNPRKTLMKSIYINIQMRPQFTIPLKDMIK 672

Mouse   330 AVEDSLYWECRASGKPKPSYRWLKNGDAL----VLEERIQIENGALTITNLNV-TDSGMFQCIAE 389
            .....:.:.|.|...|..:|.|.||.:.|    :..:|..|::..|||..|.. .|..|:||.|:
  Fly   673 DYNSDVTFICEAFAIPDANYTWYKNAERLDPANINRDRYIIQDNVLTIKFLEKDKDDAMYQCGAQ 737

Mouse   390 NKHGLIYSSAELKVVASAPDFSRNPMKKMVQVQVGSLVILDCKPRASPRALSFWKKGDMMVREQA 454
            |:....:|||:|:|::..|.|.::|::..|.........:.|.|.|:||....|||...::....
  Fly   738 NQLKTSFSSAQLRVLSMKPSFKKHPLESEVYAVYNGNTTIVCDPEAAPRPKFQWKKDGQVIGSGG 802

Mouse   455 RVSFLNDGGLKIMNVTKADAGTYTCTAENQFGKANGTTHLVVTEPTRIILAPSNMDVAVGESVI- 518
            ....|..|.|.|...::.|.|.|||.|.||.|.......::|.:..|.|..|....|:....:|
  Fly   803 HRRILPSGTLTISPTSRDDEGIYTCIASNQAGTDESHARVIVLQEIRFIETPPQRIVSKEHDLIF 867

Mouse   519 LPCQVQHDPLLDIMFAWYFNGALTDFKKDGSHFEKVGGSSSGD---LMIRNIQLKHSGKYVCMVQ 580
            |.|:...|.||||.:.|..||.:.....||:      |....|   |.:.|..::.:|.|.|:|:
  Fly   868 LHCEAAFDELLDIAYVWKHNGEVLKNNHDGT------GRIIVDWNRLTVHNTSMRDAGDYECVVK 926

Mouse   581 TGVDSVSSAAELIVRGSPGPPENVKVDEITDTTAQLSWTEGTDSHSPVISYAVQARTPFSVGWQS 645
            :.|:.:||...:.:.|:||.|..|:|.:|:.|.|.:.|.:|:.:...:..|.:..||.::..|.:
  Fly   927 SAVNEISSKTSVSIEGAPGAPGGVQVIQISKTKAIIEWVDGSHNGRAIRYYNILGRTNWNRTWVN 991

Mouse   646 VRTVPEVIDGKTHT----ATVVELNPWVEYEFRIVASNKIGGGEPSLPSEKVRTEEAAPEIAPSE 706
            |.|..:..:...:|    |.||.|.||..|||.:.|.|.:|.|.||.||....|.|..|.|||..
  Fly   992 VSTHVQAREVDRYTSRQQAEVVNLTPWSAYEFSVTAVNDLGIGTPSAPSPIYSTYEDKPYIAPRN 1056

Mouse   707 VSGGGGSRSELVITWDPVPEELQNGGGFGYVVAFRPLGVTTWIQTVVTSPDNPRYVFRNESIVP- 770
            |.||||...:|.|||||:..:.|:..|..|.|.::..|...|....:...|:......|   :|
  Fly  1057 VGGGGGKIGDLTITWDPLLPQEQHSHGIHYKVFWKLKGAIEWASDEIKKQDHMGVAVVN---IPL 1118

Mouse   771 ---FSPYEVKVGVYNNKGEGPFSPVTTVFSAEEEPTVAPSHISAHSLSSSEIEVSWNTIPWKLSN 832
               ::.|||||...|:.|:||.|.:..:.|||:.|.|||....|.:.:|:...|:|..|.....|
  Fly  1119 NNYYTEYEVKVQAINSVGKGPESEIAVIHSAEDMPQVAPQKPIALAYNSTCFNVTWQPIDMSREN 1183

Mouse   833 --GHLLGYEVRYWNNGGEEESSRKVKVAGNQTSAVLRGLKSNLAYYTAVRAYNSAGAGPFSATVN 895
              |.|:|:.::||....:||.|........:..|::.||:.:..|:..|.|||:||.||.|....
  Fly  1184 IRGKLIGHRLKYWKTTHQEEDSVYYLSRTTRNWALIVGLQPDTYYFVKVMAYNAAGEGPESERFE 1248

Mouse   896 ATTKKTPPSQPPGNV-VWNATDTKVLLNWEQVKAMENESEVTGYKVFYRTSSQNNVHVLNTNKTS 959
            ..|.:..|.:||.:| |:....:.|.:.|..|...::|..|.||||....|.||.:...||
  Fly  1249 ERTYRKAPQKPPSSVHVYGINPSTVRVVWRYVSPSQDEEPVEGYKVRIWESDQNMITANNT---- 1309

Mouse   960 AELLLPI---KEDYI----------IEVKATTDGGDGTSS 986
               ::||   .|.||          :.|.|.::||||..|
  Fly  1310 ---IVPIGQKLESYINNLTPGKSYNMRVLAYSNGGDGRMS 1346

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cntn3	NP_032805.2	Ig	25..120	CDD:416386	39/104 (38%)
		Ig strand A	27..31	CDD:409353	1/3 (33%)
		Ig strand A'	34..39	CDD:409353	1/4 (25%)
		Ig strand B	45..53	CDD:409353	3/7 (43%)
		Ig strand C	58..64	CDD:409353	3/13 (23%)
		Ig strand C'	66..69	CDD:409353	0/2 (0%)
		Ig strand D	76..80	CDD:409353	2/3 (67%)
		Ig strand E	82..88	CDD:409353	4/5 (80%)
		Ig strand F	95..104	CDD:409353	4/8 (50%)
		Ig strand G	107..120	CDD:409353	6/12 (50%)
		Ig	129..214	CDD:416386	31/84 (37%)
		Ig strand A	130..135	CDD:409353	1/4 (25%)
		Ig strand B	139..145	CDD:409353	1/5 (20%)
		Ig strand C	153..159	CDD:409353	2/5 (40%)
		Ig strand C'	164..166	CDD:409353	0/1 (0%)
		Ig strand D	171..176	CDD:409353	3/4 (75%)
		Ig strand E	179..183	CDD:409353	2/3 (67%)
		Ig strand F	193..201	CDD:409353	4/7 (57%)
		Ig strand G	203..214	CDD:409353	2/10 (20%)
		Ig	227..315	CDD:416386	31/87 (36%)
		Ig strand A	227..232	CDD:409353	2/4 (50%)
		Ig strand A'	235..240	CDD:409353	2/4 (50%)
		Ig strand B	243..252	CDD:409353	4/8 (50%)
		Ig strand C	258..262	CDD:409353	1/3 (33%)
		Ig strand C'	265..267	CDD:409353	0/1 (0%)
		Ig strand D	276..279	CDD:409353	0/2 (0%)
		Ig strand E	280..285	CDD:409353	1/4 (25%)
		Ig strand F	293..301	CDD:409353	3/7 (43%)
		Ig strand G	304..315	CDD:409353	0/10 (0%)
		Ig	320..403	CDD:416386	26/87 (30%)
		Ig strand A'	326..330	CDD:409353	1/3 (33%)
		Ig strand B	334..342	CDD:409353	1/7 (14%)
		Ig strand C	348..353	CDD:409353	2/4 (50%)
		Ig strand C'	355..358	CDD:409353	0/2 (0%)
		Ig strand D	363..367	CDD:409353	1/3 (33%)
		Ig strand E	369..374	CDD:409353	2/4 (50%)
		Ig strand F	383..390	CDD:409353	4/6 (67%)
		Ig strand G	394..403	CDD:409353	4/8 (50%)
		Ig	408..496	CDD:416386	25/87 (29%)
		Ig strand A	408..413	CDD:409353	2/4 (50%)
		Ig strand A'	416..421	CDD:409353	1/4 (25%)
		Ig strand B	425..432	CDD:409353	0/6 (0%)
		Ig strand C	440..444	CDD:409353	0/3 (0%)
		Ig strand D	458..461	CDD:409353	1/2 (50%)
		Ig strand E	462..467	CDD:409353	2/4 (50%)
		Ig strand F	475..483	CDD:409353	5/7 (71%)
		Ig strand G	489..496	CDD:409353	0/6 (0%)
		Ig	498..598	CDD:416386	29/103 (28%)
		Ig strand A	498..504	CDD:409353	1/5 (20%)
		Ig strand A'	507..512	CDD:409353	0/4 (0%)
		Ig strand B	515..523	CDD:409353	3/8 (38%)
		Ig strand C	532..536	CDD:409353	0/3 (0%)
		Ig strand E	560..564	CDD:409353	2/6 (33%)
		Ig strand F	573..580	CDD:409353	3/6 (50%)
		Ig strand G	587..591	CDD:409353	2/3 (67%)
		FN3	598..695	CDD:238020	34/100 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	684..714		16/29 (55%)
		FN3	703..795	CDD:238020	32/95 (34%)
		FN3	805..898	CDD:238020	29/94 (31%)
		FN3	906..991	CDD:238020	30/95 (32%)
Cont	NP_649461.2	CLECT	139..>223	CDD:214480
		Ig	361..460	CDD:299845	36/98 (37%)
		I-set	362..462	CDD:254352	36/99 (36%)
		Ig	466..559	CDD:299845	33/94 (35%)
		IG_like	584..657	CDD:214653	25/74 (34%)
		IGc2	586..645	CDD:197706	22/59 (37%)
		Ig	667..751	CDD:299845	26/83 (31%)
		IG_like	676..751	CDD:214653	24/74 (32%)
		IG_like	765..844	CDD:214653	22/78 (28%)
		Ig	773..844	CDD:299845	21/70 (30%)
		I-set	851..940	CDD:254352	27/94 (29%)
		Ig	866..944	CDD:299845	25/83 (30%)
		FN3	944..1043	CDD:238020	34/98 (35%)
		FN3	1053..1146	CDD:238020	32/95 (34%)
		fn3	1156..1244	CDD:278470	28/87 (32%)
		fn3	1259..1346	CDD:278470	29/93 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	72	1.000	Domainoid score	I9267
eggNOG	1	0.900	-	-		E1_KOG3513
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H7461
Inparanoid	1	1.050	495	1.000	Inparanoid score	I1379
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46028
OrthoDB	1	1.010	-	-		D292460at33208
OrthoFinder	1	1.000	-	-		FOG0000550
OrthoInspector	1	1.000	-	-		otm43749
orthoMCL	1	0.900	-	-		OOG6_100978
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X342
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.740