DRSC/TRiP Functional Genomics Resources

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Protein Alignment Cntn3 and Nrg

DIOPT Version :9

Sequence 1:NP_032805.2 Gene:Cntn3 / 18488 MGIID:99534 Length:1028 Species:Mus musculus
Sequence 2:NP_001245581.1 Gene:Nrg / 31792 FlyBaseID:FBgn0264975 Length:1309 Species:Drosophila melanogaster


Alignment Length:1057 Identity:303/1057 - (28%)
Similarity:474/1057 - (44%) Gaps:103/1057 - (9%)


- Green bases have known domain annotations that are detailed below.


Mouse     5 WKQLILLSFIGCLAGELLLQG---------PVFIKEPS--NSIFPVDSEDKK----ITLNCEARG 54
            |:|..:|:   .|...||..|         |...|:|:  ..:|.|..::|:    ..:.|||.|
  Fly     2 WRQSTILA---ALLVALLCAGSAESKGNRPPRITKQPAPGELLFKVAQQNKESDNPFIIECEADG 63

Mouse    55 NPSPHYRWQLNGSDID-TSLDHR-YKLNGGNLIVINPNRNWDTGSYQCFATNSLGTIVSREAKLQ 117
            .|.|.|.|..||...| .:.|:| .:..|...:||...::.|.|.|||||:|..||..|....::
  Fly    64 QPEPEYSWIKNGKKFDWQAYDNRMLRQPGRGTLVITIPKDEDRGHYQCFASNEFGTATSNSVYVR 128

Mouse   118 FAYLENFKTRMRSTVSVREGQGVVLLCGPPPHSGELSYAWVFNEY--PSFVEEDSRRFVSQETGH 180
            .|.|..||.....|:...||:..:|.|..|......:..|:..|.  .|....::.|......|:
  Fly   129 KAELNAFKDEAAKTLEAVEGEPFMLKCAAPDGFPSPTVNWMIQESIDGSIKSINNSRMTLDPEGN 193

Mouse   181 LYIAKVEPSDVGN---YTCVVTSTVTNTRVLGSPTPLVLRSDGV---MGEYEPKIEVQFPETLPA 239
            |:.:.|...|..:   |.|..||...:...:|:...|.::..||   ..::.|..:........|
  Fly   194 LWFSNVTREDASSDFYYACSATSVFRSEYKIGNKVLLDVKQMGVSASQNKHPPVRQYVSRRQSLA 258

Mouse   240 AKGSTVRLECFALGNPVPQINWRRSDG--MPFPNKIKLRKFNGMLEIQNFQQEDTGSYECIAENS 302
            .:|..:.|.|...|.|:||..|.: ||  :.:.::|....:...|.|:....:|.|:|.|...|.
  Fly   259 LRGKRMELFCIYGGTPLPQTVWSK-DGQRIQWSDRITQGHYGKSLVIRQTNFDDAGTYTCDVSNG 322

Mouse   303 RGK--------NVARGRLTYYAKPYWLQLLRDVEIAV---EDSLYWECRASGKPKPSYRWLKNGD 356
            .|.        ||  ..:.|:.|        :.|||.   ::.:.:||||:|.|:|...|:.||.
  Fly   323 VGNAQSFSIILNV--NSVPYFTK--------EPEIATAAEDEEVVFECRAAGVPEPKISWIHNGK 377

Mouse   357 AL---VLEERIQIENGALTITNLNVTDSGMFQCIAENKHGLIYSSAELKVVASAPDFSRNPMKKM 418
            .:   ....|..:.:..:.|.||...|:|.:.|.|.|..|.:|....|.|.|..|..|..|  ..
  Fly   378 PIEQSTPNPRRTVTDNTIRIINLVKGDTGNYGCNATNSLGYVYKDVYLNVQAEPPTISEAP--AA 440

Mouse   419 VQVQVGSLVILDCKPRASPRALSFWKKGDMMVREQARVSFLNDGGLKIMNVTKADAGTYTCTAEN 483
            |....|..|.:.|:...||:.|..|.:....: ...|.:...:|.|:|.:||.:|||.|||.|:|
  Fly   441 VSTVDGRNVTIKCRVNGSPKPLVKWLRASNWL-TGGRYNVQANGDLEIQDVTFSDAGKYTCYAQN 504

Mouse   484 QFGKANGTTHLVVTEPTRIILAPSNMDVAVGESVILPCQVQHDPLLDIMFAWYFNGALTDFKKDG 548
            :||:......|||.|.|||...|.|.:||.|:|....|...||..|:|...|:.:|...||:.. 
  Fly   505 KFGEIQADGSLVVKEHTRITQEPQNYEVAAGQSATFRCNEAHDDTLEIEIDWWKDGQSIDFEAQ- 568

Mouse   549 SHFEKVGGSSSGDLMIRNIQLKHSGKYVCMVQTGVDSVSSAAELIVRGSPGPPENVKVDEIT--D 611
            ..|.|...:|   |.|.......||:|.|:.:|.:|..::.|.|||:..|..|   |:..||  .
  Fly   569 PRFVKTNDNS---LTIAKTMELDSGEYTCVARTRLDEATARANLIVQDVPNAP---KLTGITCQA 627

Mouse   612 TTAQLSWTEGTDSHSPVISYAVQARTPFS-VGWQSV-RTVPEVIDGKTHTATVVELNPWVEYEFR 674
            ..|::.|.:..|:.||::.|.:|..|.|: ..|.:. ..||     .|.::.||:::||..|.||
  Fly   628 DKAEIHWEQQGDNRSPILHYTIQFNTSFTPASWDAAYEKVP-----NTDSSFVVQMSPWANYTFR 687

Mouse   675 IVASNKIGGGEPSLPSEKVRTEEAAPEIAPSEVSGGGGSRSELVITWDPVPEELQNGGGFGYVVA 739
            ::|.||||...||..|:...|:...|...|..|.|.|...:.|||:|.|:||...|...|.|.|:
  Fly   688 VIAFNKIGASPPSAHSDSCTTQPDVPFKNPDNVVGQGTEPNNLVISWTPMPEIEHNAPNFHYYVS 752

Mouse   740 F-RPLGVTTWIQTVVTSPDNPRYVFRNESIV-----PFSPYEVKVGVYNNKGEGPFSPVTTV-FS 797
            : |.:....|       .:|..:.:|..:||     .|..|.:||...|::||...:....| :|
  Fly   753 WKRDIPAAAW-------ENNNIFDWRQNNIVIADQPTFVKYLIKVVAINDRGESNVAAEEVVGYS 810

Mouse   798 AEEEPTVAPSHISAHSLSSSEI-EVSWNTIPWKLSNGHLLGYEVRYWNNGGEEESSRKVKVAGNQ 861
            .|:.|..||::.:...::||.. .::|..:..:...||..||:::.|.....||..|::.|.|:.
  Fly   811 GEDRPLDAPTNFTMRQITSSTSGYMAWTPVSEESVRGHFKGYKIQTWTENEGEEGLREIHVKGDT 875

Mouse   862 TSAVLRGLKSNLAYYTAVRAYNSAGAGPFSATVNATTKKTPPSQPPGNVVWNATDTKVLLNWEQV 926
            .:|::...|.:...|..:.|||....||.||.::..|.:..||...|...:....:..:|:|:  
  Fly   876 HNALVTQFKPDSKNYARILAYNGRFNGPPSAVIDFDTPEGVPSPVQGLDAYPLGSSAFMLHWK-- 938

Mouse   927 KAMENESEVTGYKVFYRTSSQNNV--------HVLNTNKTSAELL-LPIKEDYIIEVKATTDGGD 982
            |.:....::||||::|....::.|        |:.:...|..::. |.....|.|.:.|||..|:
  Fly   939 KPLYPNGKLTGYKIYYEEVKESYVGERREYDPHITDPRVTRMKMAGLKPNSKYRISITATTKMGE 1003

Mouse   983 GTSSEQIRIPRITSMDA 999
            |  ||.. |.:.|..||
  Fly  1004 G--SEHY-IEKTTLKDA 1017

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Cntn3NP_032805.2 Ig 25..120 CDD:416386 34/111 (31%)
Ig strand A 27..31 CDD:409353 0/3 (0%)
Ig strand A' 34..39 CDD:409353 1/4 (25%)
Ig strand B 45..53 CDD:409353 2/11 (18%)
Ig strand C 58..64 CDD:409353 3/5 (60%)
Ig strand C' 66..69 CDD:409353 1/2 (50%)
Ig strand D 76..80 CDD:409353 1/4 (25%)
Ig strand E 82..88 CDD:409353 1/5 (20%)
Ig strand F 95..104 CDD:409353 6/8 (75%)
Ig strand G 107..120 CDD:409353 3/12 (25%)
Ig 129..214 CDD:416386 19/89 (21%)
Ig strand A 130..135 CDD:409353 1/4 (25%)
Ig strand B 139..145 CDD:409353 1/5 (20%)
Ig strand C 153..159 CDD:409353 1/5 (20%)
Ig strand C' 164..166 CDD:409353 1/1 (100%)
Ig strand D 171..176 CDD:409353 1/4 (25%)
Ig strand E 179..183 CDD:409353 2/3 (67%)
Ig strand F 193..201 CDD:409353 3/10 (30%)
Ig strand G 203..214 CDD:409353 1/10 (10%)
Ig 227..315 CDD:416386 23/97 (24%)
Ig strand A 227..232 CDD:409353 1/4 (25%)
Ig strand A' 235..240 CDD:409353 0/4 (0%)
Ig strand B 243..252 CDD:409353 2/8 (25%)
Ig strand C 258..262 CDD:409353 1/3 (33%)
Ig strand C' 265..267 CDD:409353 2/3 (67%)
Ig strand D 276..279 CDD:409353 0/2 (0%)
Ig strand E 280..285 CDD:409353 1/4 (25%)
Ig strand F 293..301 CDD:409353 3/7 (43%)
Ig strand G 304..315 CDD:409353 3/18 (17%)
Ig 320..403 CDD:416386 25/88 (28%)
Ig strand A' 326..330 CDD:409353 1/3 (33%)
Ig strand B 334..342 CDD:409353 3/7 (43%)
Ig strand C 348..353 CDD:409353 1/4 (25%)
Ig strand C' 355..358 CDD:409353 1/2 (50%)
Ig strand D 363..367 CDD:409353 1/3 (33%)
Ig strand E 369..374 CDD:409353 0/4 (0%)
Ig strand F 383..390 CDD:409353 2/6 (33%)
Ig strand G 394..403 CDD:409353 2/8 (25%)
Ig 408..496 CDD:416386 28/87 (32%)
Ig strand A 408..413 CDD:409353 2/4 (50%)
Ig strand A' 416..421 CDD:409353 1/4 (25%)
Ig strand B 425..432 CDD:409353 1/6 (17%)
Ig strand C 440..444 CDD:409353 1/3 (33%)
Ig strand D 458..461 CDD:409353 0/2 (0%)
Ig strand E 462..467 CDD:409353 2/4 (50%)
Ig strand F 475..483 CDD:409353 5/7 (71%)
Ig strand G 489..496 CDD:409353 1/6 (17%)
Ig 498..598 CDD:416386 34/99 (34%)
Ig strand A 498..504 CDD:409353 4/5 (80%)
Ig strand A' 507..512 CDD:409353 1/4 (25%)
Ig strand B 515..523 CDD:409353 2/7 (29%)
Ig strand C 532..536 CDD:409353 0/3 (0%)
Ig strand E 560..564 CDD:409353 1/3 (33%)
Ig strand F 573..580 CDD:409353 3/6 (50%)
Ig strand G 587..591 CDD:409353 0/3 (0%)
FN3 598..695 CDD:238020 33/100 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 684..714 9/29 (31%)
FN3 703..795 CDD:238020 28/97 (29%)
FN3 805..898 CDD:238020 25/93 (27%)
FN3 906..991 CDD:238020 22/93 (24%)
NrgNP_001245581.1 Ig 55..128 CDD:299845 27/72 (38%)
IG_like 57..127 CDD:214653 27/69 (39%)
Ig 135..214 CDD:299845 18/78 (23%)
IG_like 141..216 CDD:214653 16/74 (22%)
ig 251..332 CDD:278476 20/81 (25%)
I-set 339..427 CDD:254352 27/95 (28%)
Ig 354..427 CDD:299845 22/72 (31%)
I-set 432..517 CDD:254352 28/87 (32%)
Ig 446..517 CDD:299845 24/71 (34%)
I-set 522..611 CDD:254352 30/92 (33%)
ig 525..609 CDD:278476 27/87 (31%)
FN3 613..707 CDD:238020 33/101 (33%)
FN3 716..807 CDD:238020 28/97 (29%)
fn3 817..905 CDD:278470 23/87 (26%)
FN3 917..1004 CDD:238020 21/88 (24%)
FN3 1041..1111 CDD:238020
Bravo_FIGEY 1155..>1221 CDD:290593
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3513
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.810

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