DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pak3 and Pak3

DIOPT Version :9

Sequence 1:	NP_001181975.1	Gene:	Pak3 / 18481	MGIID:	1339656	Length:	580	Species:	Mus musculus
Sequence 2:	NP_001262638.1	Gene:	Pak3 / 41995	FlyBaseID:	FBgn0044826	Length:	583	Species:	Drosophila melanogaster

Alignment Length:	592	Identity:	229/592 - (38%)
Similarity:	324/592 - (54%)	Gaps:	124/592 - (20%)

- Green bases have known domain annotations that are detailed below.

Mouse    69 EISLPSDFEHTIHVGFDAVTGEFTNSPFQTSRPVTVASSQSEGKMPDLYGSQMCPGKLPEGIPEQ 133
            ||..|::|:...||..:..||:.                                    ||:|..
  Fly    19 EIGAPTNFQRHFHVSRNQETGDL------------------------------------EGLPAP 47

Mouse   134 WARLLQTSNITKLEQKKNPQAVLDVLKFYD-SKETVNNQKYMSFTSGD------KSAHGYI---- 187
            |.||: .|.||:.||.|||.|....:|:|: |.:...|:.:..|.:.|      |....|:
  Fly    48 WVRLM-NSQITRDEQDKNPDAAYHAVKYYNYSIKKKENEVFKPFITEDVIHEESKEIENYVNYKN 111

Mouse   188 -----------------------------AAHQSNTKTASEPPLAPPVSEEEDEEEEEEEDDN-- 221
                                         :|..||:.:.::......|..:..||..:|...|
  Fly   112 KHKSQDPEKSDDDGSSTATETESSSGCGSSAGNSNSSSINDSSQQSTVPLDALEEVFKELKTNLE 176

Mouse   222 ----------EPPPV--------------IAPRPEHTKSIYTRSVV--------------ESIAS 248
                      |||||              |.|:|..|:.....|.:              ::|..
  Fly   177 HRETLKAAPQEPPPVPPKKSPHTIPPKPQIKPKPRVTQKFSRTSDIRRDEDSDNQHKINTDTIII 241

Mouse   249 PAAPNKEDIPPSAENANSTTLYRNTDRQRKKSKMTDEEILEKLRSIVSVGDPKKKYTRFEKIGQG 313
            ..|...:| ..:.:|.:.|.|.|:   :.|:::.||.||..:||:|.:..||:::|...:::|:|
  Fly   242 KPAVGAQD-AGADDNPDETILRRS---KEKRAQKTDAEIYVELRAICNSDDPRERYKTTQEVGKG 302

Mouse   314 ASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLV--GDELWV 376
            |||.|:.|.|:....:||:|.::::.|..|:||:.||.|:::..:.|:||:||:||:  .|:|||
  Fly   303 ASGIVFIAADLQNESQVAVKTIDMKNQSSKDLILTEIRVLKDFNHKNLVNFLDAYLLEPEDQLWV 367

Mouse   377 VMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTD 441
            ||||:.||.||||||||.|.|.|||.||||.|.|:.|||:..:|||||||||:|||||||||:||
  Fly   368 VMEYMDGGPLTDVVTETVMKERQIACVCRETLYAISFLHAKGIIHRDIKSDNVLLGMDGSVKVTD 432

Mouse   442 FGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRA 506
            |||||.|..:: ||.|||||||||||||||||.||.||||||:|||||||:||:||||.|.||||
  Fly   433 FGFCANIEGDE-KRQTMVGTPYWMAPEVVTRKKYGKKVDIWSIGIMAIEMIEGQPPYLYETPLRA 496

Mouse   507 LYLIATNGTPELQNPERLSAVFRDFLNRCLEMDVDRRGSAKELLQHPFLKLAKPLSSLTPLIIAA 571
            |||||.||.|::::.::||...:|||:|||:::||||.:|.|||.||||.....:.:|.|.|.||
  Fly   497 LYLIAANGRPDIKSWDKLSPNLQDFLDRCLQVEVDRRATADELLSHPFLNDCSEVKALVPNIKAA 561

Mouse   572 KEAIKNS 578
            |:.::.:
  Fly   562 KKVLRRN 568

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pak3	NP_001181975.1	CRIB_PAK_like	68..149	CDD:238526	18/79 (23%)
Pak3	NP_001181975.1	STKc_PAK3	284..580	CDD:132987	171/297 (58%)
Pak3	NP_001262638.1	PBD	19..73	CDD:279166	8/53 (15%)
		PKc_like	288..545	CDD:304357	151/243 (62%)
		S_TKc	293..545	CDD:214567	150/238 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0578
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D425477at33208
OrthoFinder	1	1.000	-	-		FOG0000763
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100484
Panther	1	1.100	-	-	O	PTHR48015
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.820