Protein Alignment DUSP6 and ssh

DIOPT Version :10

• Sequence 1: NP_001937.2
• Gene: DUSP6 / 1848
• HGNCID: 3072
• Length: 381
• Species: Homo sapiens
• Sequence 2: NP_733063.1
• Gene: ssh / 42986
• FlyBaseID: FBgn0029157
• Length: 1193
• Species: Drosophila melanogaster
• Alignment Length: 395
• Identity: 96/395 - (24%)
• Similarity: 157/395 - (39%)
• Gaps: 103/395 - (26%)

Human    17 SKTVAWLNEQLELG---NERL-------LLMDCR---------PQELYESSHIESAINVAIPGIM 62
            :|..:.:.|...||   |||.       :|.|..         ..::||.:||...::|......
  Fly   193 NKNTSGMEESCLLGIDCNERTTIGLVVPILADTTIHLDGDGGFSVKVYEKTHIFKPVSVQAMWSA 257

Human    63 LRRLQKGNLPVRA--LFTRGEDRD---RFTRRCGTDTVVLYDESSSDWN---------------- 106
            |:.|.|.:...|.  .:..|...|   .:.||..:|...|     ::||
  Fly   258 LQTLHKVSKKARENNFYASGPSHDWLSSYERRIESDQSCL-----NEWNAMDALESRRPPSPDAI 317

Human   107 -----ENTGGESVLGLLLKKLK-----DEGCRAFYLEGGFSKFQAEFSLHCETNLDGSCSSSSPP 161
                 |....|||:.:.||.:.     || ..:.|:.|           ..|..||
  Fly   318 RNKPPEKEETESVIKMKLKAIMMSVDLDE-VTSKYIRG-----------RLEEILD--------- 361

Human   162 LPVLGLGGLRISSDSSSDIESDLDRDPNSATDSDGSPLSNSQPSFPVEILPFLYLGCAKDSTNLD 226
               :.||      :..|.|::::             .:...|...|.:|...:|||...:::||:
  Fly   362 ---MDLG------EYKSFIDAEM-------------LVILGQMDAPTKIFEHVYLGSEWNASNLE 404

Human   227 VLEEFGIKYILNVTPNLPNLFENAGEFKYKQIPISDHWSQNLSQFFPEAISFIDEARGKNCGVLV 291
            .|::.|:::|||||..:.|.|  .|.|:|..:.:.|....||.:::.:...:|..|:.:...|||
  Fly   405 ELQKNGVRHILNVTREIDNFF--PGTFEYFNVRVYDDEKTNLLKYWDDTFRYITRAKAEGSKVLV 467

Human   292 HCLAGISRSVTVTVAYLMQKLNLSMNDAYDIVKMKKSNISPNFNFMGQLLDFERTLGLSSPCDNR 356
            ||..|:|||.:|.:||.|:........|.:.||.::|.|.||.||:.||   |...|:.....|:
  Fly   468 HCKMGVSRSASVVIAYAMKAYQWEFQQALEHVKKRRSCIKPNKNFLNQL---ETYSGMLDAMKNK 529

Human   357 VPAQQ 361
            ...|:
  Fly   530 EKLQR 534

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DUSP6	NP_001937.2	DSP_MapKP	17..147	CDD:238723	36/179 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	176..203		2/26 (8%)
		DSP_MKP_classII	207..343	CDD:350414	48/135 (36%)
ssh	NP_733063.1	SSH-N	21..313	CDD:212166	26/124 (21%)
		DEK_C	326..379	CDD:462592	16/95 (17%)
		DSP_slingshot	385..523	CDD:350363	50/142 (35%)