DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DUSP6 and puc

DIOPT Version :9

Sequence 1:	NP_001937.2	Gene:	DUSP6 / 1848	HGNCID:	3072	Length:	381	Species:	Homo sapiens
Sequence 2:	NP_524273.1	Gene:	puc / 40958	FlyBaseID:	FBgn0243512	Length:	476	Species:	Drosophila melanogaster

Alignment Length:	213	Identity:	86/213 - (40%)
Similarity:	115/213 - (53%)	Gaps:	15/213 - (7%)

- Green bases have known domain annotations that are detailed below.

Human   173 SSDSSSDIESDLDRDPNSATDSDGSPL---SNSQPSFPVEILPFLYLGCAKDSTNLDVLEEFGIK 234
            |:.|||...:...|.| :.|.|..||.   ..:.|:.||  .|.|.||..:|:   |.....|..
  Fly   100 STTSSSTAMNGGGRTP-ALTRSCSSPAVYDIETHPASPV--FPHLLLGNGRDA---DDPSSVGAN 158

Human   235 YILNVTPNLPNLFENAGEFKYKQIPISDHWSQNLSQFFPEAISFIDEARGKNCGVLVHCLAGISR 299
            .:||||...||.....| .||.|||.||...||:.|:|.||..||::||.....||:||.|||||
  Fly   159 CVLNVTCQSPNESHLQG-LKYMQIPASDTPHQNIKQYFQEAYDFIEDARKTGSRVLLHCHAGISR 222

Human   300 SVTVTVAYLMQKLNLSMNDAYDIVKMKKSNISPNFNFMGQLLDFERTLGLSSPCDNRVPAQQLYF 364
            |.|:.:||:|:..:||:.:||.:||:.:..||||.|||||||:.|:.|..|.......|    :.
  Fly   223 SATIAIAYVMRYKSLSLLEAYKLVKVARPIISPNLNFMGQLLELEQNLRKSGVLAPATP----HL 283

Human   365 TTPSNQNVYQVD-SLQST 381
            .:|||.:...|. |.||:
  Fly   284 NSPSNPSSSSVGLSTQSS 301

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DUSP6	NP_001937.2	DSP_MapKP	17..147	CDD:238723
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	176..203		9/29 (31%)
		DSPc	207..344	CDD:238073	64/136 (47%)
puc	NP_524273.1	DSPc	133..267	CDD:238073	65/139 (47%)
puc	NP_524273.1	CDC14	<193..272	CDD:225297	41/78 (53%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2281
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.940