Protein Alignment DUSP6 and Mkp3

DIOPT Version :10

• Sequence 1: NP_001937.2
• Gene: DUSP6 / 1848
• HGNCID: 3072
• Length: 381
• Species: Homo sapiens
• Sequence 2: NP_001262031.1
• Gene: Mkp3 / 40081
• FlyBaseID: FBgn0036844
• Length: 497
• Species: Drosophila melanogaster
• Alignment Length: 351
• Identity: 145/351 - (41%)
• Similarity: 208/351 - (59%)
• Gaps: 28/351 - (7%)

Human    22 WLNEQL-ELGNERLLLMDCRPQELYESSHIESAINVAIPGIMLRRLQKGNLPVRALFTRGEDRDR 85
            ||..|| .|.::.|:|:|||....|..|||..|:|:.||.|:||||..|.:.:.:.....|.:.|
  Fly    13 WLQSQLRSLDSKDLILLDCRGSHEYSESHIRGAVNLCIPSIVLRRLAVGKIDLASTIKSPELKQR 77

Human    86 FTRRCGTDTVVLYD-ESSSDWNENTGG--------ESVLGLLLKKLKDEGCRAFYLEGGFSKFQA 141
            ..........:||: |.....|:...|        :|::.:|.::||.:|||...|:.||:.|:.
  Fly    78 IQSGYKLCWFILYNGEGVPGQNQEIAGAGSLAVAMDSIISILHRRLKQDGCRVVALQDGFNNFRQ 142

Human   142 EFSLHCETN-------LDGSCSSSSPPLPVLGLGGLRIS---SDS--SSDIESDLDRDPNSATDS 194
            .|...||.:       ::.|.:..:..|  :||..||||   |||  ||..||.   |..|::..
  Fly   143 AFPEWCEDDNQTHSKEIESSRNVQTDQL--MGLRSLRISTTQSDSACSSSAESS---DCESSSHH 202

Human   195 DGSPLSNSQPSFPVEILP-FLYLGCAKDSTNLDVLEEFGIKYILNVTPNLPNLFENAGEFKYKQI 258
            ......::....||||:| .|:||.|..|.:.:.|:::.|||:|||||:|||.|:.:|:.||.||
  Fly   203 HHHHSHHNYNEAPVEIIPGLLFLGNATHSCDSEALKKYNIKYVLNVTPDLPNKFKESGDIKYLQI 267

Human   259 PISDHWSQNLSQFFPEAISFIDEARGKNCGVLVHCLAGISRSVTVTVAYLMQKLNLSMNDAYDIV 323
            ||:||:||:|:..||:||.||:|||..:..||||||||:|||||||:||||....||:|||:.:|
  Fly   268 PITDHYSQDLAIHFPDAIQFIEEARSASSVVLVHCLAGVSRSVTVTLAYLMHTRGLSLNDAFAMV 332

Human   324 KMKKSNISPNFNFMGQLLDFERTLGL 349
            :.:|.::||||:||.|||.||..|.|
  Fly   333 RDRKPDVSPNFHFMQQLLSFESQLRL 358

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DUSP6	NP_001937.2	DSP_MapKP	17..147	CDD:238723	43/134 (32%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	176..203		7/28 (25%)
		DSP_MKP_classII	207..343	CDD:350414	79/136 (58%)
Mkp3	NP_001262031.1	DSP_MapKP	8..148	CDD:238723	43/134 (32%)
		DSP_MKP_classII	215..352	CDD:350414	79/136 (58%)