DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pak1 and hpo

DIOPT Version :9

Sequence 1:	NP_001344291.1	Gene:	Pak1 / 18479	MGIID:	1339975	Length:	552	Species:	Mus musculus
Sequence 2:	NP_001261092.1	Gene:	hpo / 37247	FlyBaseID:	FBgn0261456	Length:	669	Species:	Drosophila melanogaster

Alignment Length:	306	Identity:	117/306 - (38%)
Similarity:	184/306 - (60%)	Gaps:	16/306 - (5%)

- Green bases have known domain annotations that are detailed below.

Mouse   251 KKPKMSDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTAMDVATGQEVAIKQMNLQQQPK 315
            |..|:|:|.:|:         .|:|.:....|:|:|:.|:||.|:...:...||||.:.::....
  Fly    25 KLKKLSEESLLQ---------PPEKVFDIMYKLGEGSYGSVYKAVHKESSSIVAIKLVPVESDLH 80

Mouse   316 KELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDV--VTETCMDEGQIAAVCR 378
            :  ||.||.:|::..:|.:|.|..||....:||:.|||...||::|:  :.:..:.|.:||.:..
  Fly    81 E--IIKEISIMQQCDSPYVVRYYGSYFKQYDLWICMEYCGAGSVSDIMRLRKKTLTEDEIATILS 143

Mouse   379 ECLQALEFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVV 443
            :.||.|.:||..:.||||||:.||||..:|..||.|||...|:|...:||:|::|||:||||||:
  Fly   144 DTLQGLVYLHLRRKIHRDIKAANILLNTEGYAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVI 208

Mouse   444 TRKAYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATNGTPELQNPEKLSAIFRDFLNRC 508
            ....|....|||||||.|:||.||:|||...:|:||:::|.....|..:.|::.|..|.||:::|
  Fly   209 EEIGYDCVADIWSLGITALEMAEGKPPYGEIHPMRAIFMIPQKPPPSFREPDRWSTEFIDFVSKC 273

Mouse   509 LEMDVEKRGSAKELLQHQFLKIAKPLSSLTPLI---AAAKEATKNN 551
            |..:.:.|.:|.|||:|:|::.||..|.|.|::   .|.:|..:.|
  Fly   274 LVKEPDDRATATELLEHEFIRNAKHRSILKPMLEETCAIREQQRAN 319

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pak1	NP_001344291.1	PBD	74..128	CDD:334253
Pak1	NP_001344291.1	STKc_PAK1	256..551	CDD:270820	114/299 (38%)
hpo	NP_001261092.1	STKc_MST1_2	38..293	CDD:132943	103/256 (40%)
		S_TKc	42..293	CDD:214567	101/252 (40%)
		Mst1_SARAH	608..655	CDD:288481
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910