DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pah and ple

DIOPT Version :9

Sequence 1:	NP_032803.2	Gene:	Pah / 18478	MGIID:	97473	Length:	453	Species:	Mus musculus
Sequence 2:	NP_001286955.1	Gene:	ple / 38746	FlyBaseID:	FBgn0005626	Length:	579	Species:	Drosophila melanogaster

Alignment Length:	447	Identity:	212/447 - (47%)
Similarity:	294/447 - (65%)	Gaps:	11/447 - (2%)

- Green bases have known domain annotations that are detailed below.

Mouse    16 SDFGQETSYI------EDNSNQNGAV---SLIFSLKEEVGALAKVLRLFEENEINLTHIESRPSR 71
            :|:|.....|      .::|:...|:   :|:..|||.:.:|.::|:..|.....:.|:|||.||
  Fly   131 NDYGLTEDEILLANAASESSDAEAAMQSAALVVRLKEGISSLGRILKAIETFHGTVQHVESRQSR 195

Mouse    72 LNKDEYEFFTYLDKRSKPVLGSIIKSLRNDIGATVHELSRDKEKNT-VPWFPRTIQELDRFANQI 135
            :...:::....||.....:| .:|:|||.....:...|..|...|. .||||:...|||...:.:
  Fly   196 VEGVDHDVLIKLDMTRGNLL-QLIRSLRQSGSFSSMNLMADNNLNVKAPWFPKHASELDNCNHLM 259

Mouse   136 LSYGAELDADHPGFKDPVYRARRKQFADIAYNYRHGQPIPRVEYTEEERKTWGTVFRTLKALYKT 200
            ..|..:||.:||||.|.|||.|||:.|:||:.|::|.|||.::|::.|.|||.:||:|::.|...
  Fly   260 TKYEPDLDMNHPGFADKVYRQRRKEIAEIAFAYKYGDPIPFIDYSDVEVKTWRSVFKTVQDLAPK 324

Mouse   201 HACYEHNHIFPLLEKYCGFREDNIPQLEDVSQFLQTCTGFRLRPVAGLLSSRDFLGGLAFRVFHC 265
            |||.|:...|..|:....|.|..:|||:::|.||:..|||.|||.||||::||||..||||:|..
  Fly   325 HACAEYRAAFQKLQDEQIFVETRLPQLQEMSDFLRKNTGFSLRPAAGLLTARDFLASLAFRIFQS 389

Mouse   266 TQYIRHGSKPMYTPEPDICHELLGHVPLFSDRSFAQFSQEIGLASLGAPDEYIEKLATIYWFTVE 330
            |||:||.:.|.:|||||..||||||:||.:|.||||||||||||||||.||.||||:|:||||||
  Fly   390 TQYVRHVNSPYHTPEPDSIHELLGHMPLLADPSFAQFSQEIGLASLGASDEEIEKLSTVYWFTVE 454

Mouse   331 FGLCKEGDSIKAYGAGLLSSFGELQYCLSDKPKLLPLELEKTACQEYTVTEFQPLYYVAESFNDA 395
            ||||||...|||||||||||:|||.:.:|||.:....|...||.|.|...|:||:|||||||.||
  Fly   455 FGLCKEHGQIKAYGAGLLSSYGELLHAISDKCEHRAFEPASTAVQPYQDQEYQPIYYVAESFEDA 519

Mouse   396 KEKVRTFAATIPRPFSVRYDPYTQRVEVLDNTQQLKILADSINSEVGILCHALQKIK 452
            |:|.|.:.:|:.|||.||::|:|:||||||:..:|:.|...:|:|:..|.:|:.|::
  Fly   520 KDKFRRWVSTMSRPFEVRFNPHTERVEVLDSVDKLETLVHQMNTEILHLTNAISKLR 576

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pah	NP_032803.2	Phe4hydrox_tetr	20..452	CDD:130335	210/441 (48%)
		ACT_PAH	21..110	CDD:153203	23/97 (24%)
		Biopterin_H	119..449	CDD:278766	183/329 (56%)
ple	NP_001286955.1	Tyr_3_monoox	130..576	CDD:130336	212/445 (48%)
		ACT	130..234	CDD:298841	26/103 (25%)
		Biopterin_H	243..573	CDD:278766	183/329 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3186
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D361696at33208
OrthoFinder	1	1.000	-	-		FOG0000587
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.820