DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DUSP5 and CG10089

DIOPT Version :9

Sequence 1:	NP_004410.3	Gene:	DUSP5 / 1847	HGNCID:	3071	Length:	384	Species:	Homo sapiens
Sequence 2:	NP_001261803.1	Gene:	CG10089 / 39517	FlyBaseID:	FBgn0036369	Length:	447	Species:	Drosophila melanogaster

Alignment Length:	205	Identity:	60/205 - (29%)
Similarity:	89/205 - (43%)	Gaps:	45/205 - (21%)

- Green bases have known domain annotations that are detailed below.

Human   181 EILPFLYLGSAYHASK----CEFLANLHITALLNVSRRTSEACATHLHYKWIPVEDSHTADISSH 241
            ::||.||:|: |..||    .|.....||.|:.:..||    .....||..:...|:...::|.:
  Fly     7 KVLPGLYVGN-YRDSKDHAQLERFKISHIIAIHDSPRR----LLPDKHYLCVMASDTPDQNLSQY 66

Human   242 FQEAIDFIDCVREKGGKVLVHCEAGISRSPTICMAYLMKTKQFRLKEAFDYIKQRRSMVSPNFGF 306
            |....|||...|.:.|.||:||.||:|||.|:.:||:|.......|||...::..|::.:||.||
  Fly    67 FSVCNDFIHAARLREGNVLIHCLAGMSRSVTVAVAYIMTATHLNWKEALKVVRAGRAVANPNAGF 131

Human   307 MGQLLQYESEILPSTPNPQPPSCQGEAAGSSLIGHLQTLSPDMQGAYCTFPASVLAPVPTHSTVS 371
            ..||.::|.                           ..||.:.:.....||:|.|         .
  Fly   132 QSQLQEFEQ---------------------------FKLSEERRRLRERFPSSAL---------E 160

Human   372 ELSRSPVATA 381
            :|.|:.||||
  Fly   161 QLDRTKVATA 170

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DUSP5	NP_004410.3	DSP_MapKP	5..140	CDD:238723
		Nuclear localization signal. /evidence=ECO:0000255	53..74
		DSPc	178..314	CDD:238073	47/136 (35%)
		CDC14	<227..311	CDD:225297	30/83 (36%)
CG10089	NP_001261803.1	DSPc	4..139	CDD:238073	47/136 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1716
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1576308at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820