Protein Alignment DUSP4 and Mkp3

DIOPT Version :9

• Sequence 1: NP_001385.1
• Gene: DUSP4 / 1846
• HGNCID: 3070
• Length: 394
• Species: Homo sapiens
• Sequence 2: NP_001262031.1
• Gene: Mkp3 / 40081
• FlyBaseID: FBgn0036844
• Length: 497
• Species: Drosophila melanogaster
• Alignment Length: 442
• Identity: 130/442 - (29%)
• Similarity: 200/442 - (45%)
• Gaps: 105/442 - (23%)

Human    46 LLLDCRPFLAHSAGYILGSVNVRCNTIV-RRRAKGSVSLEQILPAEEEVRARLRSG-------LY 102
            :|||||....:|..:|.|:||:...:|| ||.|.|.:.|...:.: .|::.|::||       ||
  Fly    27 ILLDCRGSHEYSESHIRGAVNLCIPSIVLRRLAVGKIDLASTIKS-PELKQRIQSGYKLCWFILY 90

Human   103 SAVIVYDERSPRAE----SLREDSTVSLVVQALRRNAERTDICLLKGGYERFSSEYPEFCS---- 159
            :...|..:....|.    ::..||.:|::.:.|:::..|  :..|:.|:..|...:||:|.
  Fly    91 NGEGVPGQNQEIAGAGSLAVAMDSIISILHRRLKQDGCR--VVALQDGFNNFRQAFPEWCEDDNQ 153

Human   160 ------------KTKALAAIPPPVPPSATEPLDLGCSS------CGTPLHD---------QGGPV 197
                        :|..|..: ..:..|.|:. |..|||      |.:..|.         ...||
  Fly   154 THSKEIESSRNVQTDQLMGL-RSLRISTTQS-DSACSSSAESSDCESSSHHHHHHSHHNYNEAPV 216

Human   198 EILP-FLYLGSAYHAARRDMLDALGITALLNVSSDCPNHFE--GHYQYKCIPVEDNHKADISSWF 259
            ||:| .|:||:|.|:...:.|....|..:|||:.|.||.|:  |..:|..||:.|::..|::..|
  Fly   217 EIIPGLLFLGNATHSCDSEALKKYNIKYVLNVTPDLPNKFKESGDIKYLQIPITDHYSQDLAIHF 281

Human   260 MEAIEYIDAVKDCRGRVLVHCQAGISRSATICLAYLMMKKRVRLEEAFEFVKQRRSIISPNFSFM 324
            .:||::|:..:.....|||||.||:|||.|:.|||||..:.:.|.:||..|:.|:..:||||.||
  Fly   282 PDAIQFIEEARSASSVVLVHCLAGVSRSVTVTLAYLMHTRGLSLNDAFAMVRDRKPDVSPNFHFM 346

Human   325 GQLLQFESQV-------------------------LATSCA-AEAASPSGPL------------- 350
            .|||.||||:                         :||..| |...||...:
  Fly   347 QQLLSFESQLRLRPGSRFSCSCIAPDCNCMQTTGFMATHLANATGVSPDSGIEFDRWTPSDTGLK 411

Human   351 --RERGKTPATPTSQFVFSFPVSVGVHSAPSSLPYL-------HSPITTSPS 393
              :..||:...|.||.|   |.:.   :|.|.||..       .||.:|:.|
  Fly   412 XEQSGGKSFVLPPSQEV---PFAA---AATSPLPMCLAVNPDNMSPASTTSS 457

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DUSP4	NP_001385.1	DSP_MapKP	9..158	CDD:238723	35/123 (28%)
		DSPc	195..331	CDD:238073	59/138 (43%)
Mkp3	NP_001262031.1	DSP_MapKP	8..148	CDD:238723	35/123 (28%)
		DSPc	215..353	CDD:238073	59/137 (43%)
		CDC14	<242..359	CDD:225297	52/116 (45%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2281
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.940