DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DUSP1 and Mkp3

DIOPT Version :9

Sequence 1:	NP_004408.1	Gene:	DUSP1 / 1843	HGNCID:	3064	Length:	367	Species:	Homo sapiens
Sequence 2:	NP_001262031.1	Gene:	Mkp3 / 40081	FlyBaseID:	FBgn0036844	Length:	497	Species:	Drosophila melanogaster

Alignment Length:	438	Identity:	134/438 - (30%)
Similarity:	197/438 - (44%)	Gaps:	103/438 - (23%)

- Green bases have known domain annotations that are detailed below.

Human    25 LLLDCRSFFAFNAGHIAGSVNVRFSTIV-RRRAKGAMGLEHIVPNAELRGRLLAGAYHAVVLLDE 88
            :|||||....::..||.|:||:...:|| ||.|.|.:.|...:.:.||:.|:.:| |.....:..
  Fly    27 ILLDCRGSHEYSESHIRGAVNLCIPSIVLRRLAVGKIDLASTIKSPELKQRIQSG-YKLCWFILY 90

Human    89 RSAALDGAKRD----GTLALAAGAL------------CREARAAQVFFLKGGYEAFSASCPELCS 137
            ....:.|..::    |:||:|..::            ||      |..|:.|:..|..:.||.|.
  Fly    91 NGEGVPGQNQEIAGAGSLAVAMDSIISILHRRLKQDGCR------VVALQDGFNNFRQAFPEWCE 149

Human   138 KQSTP----------------MGL-SLPLSTSVPDSA------ESGCSSCSTPLYDQG------G 173
            ..:..                ||| ||.:||:..|||      .|.|.|.|...:...      .
  Fly   150 DDNQTHSKEIESSRNVQTDQLMGLRSLRISTTQSDSACSSSAESSDCESSSHHHHHHSHHNYNEA 214

Human   174 PVEILP-FLYLGSAYHASRKDMLDALGITALINVSANCPNHFE--GHYQYKSIPVEDNHKADISS 235
            ||||:| .|:||:|.|:...:.|....|..::||:.:.||.|:  |..:|..||:.|::..|::.
  Fly   215 PVEIIPGLLFLGNATHSCDSEALKKYNIKYVLNVTPDLPNKFKESGDIKYLQIPITDHYSQDLAI 279

Human   236 WFNEAIDFIDSIKNAGGRVFVHCQAGISRSATICLAYLMRTNRVKLDEAFEFVKQRRSIISPNFS 300
            .|.:||.||:..::|...|.|||.||:|||.|:.|||||.|..:.|::||..|:.|:..:||||.
  Fly   280 HFPDAIQFIEEARSASSVVLVHCLAGVSRSVTVTLAYLMHTRGLSLNDAFAMVRDRKPDVSPNFH 344

Human   301 FMGQLLQFESQV------------LAPHC--------------SAEAGSPAMAV-LDRGTSTTT- 337
            ||.|||.||||:            :||.|              :|...||...: .||.|.:.|
  Fly   345 FMQQLLSFESQLRLRPGSRFSCSCIAPDCNCMQTTGFMATHLANATGVSPDSGIEFDRWTPSDTG 409

Human   338 ---------VFNFPVSIPVHSTNSALSYL----------QSPITTSPS 366
                     .|..|.|..|....:|.|.|          .||.:|:.|
  Fly   410 LKXEQSGGKSFVLPPSQEVPFAAAATSPLPMCLAVNPDNMSPASTTSS 457

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DUSP1	NP_004408.1	DSP_MapKP	7..136	CDD:238723	35/127 (28%)
DUSP1	NP_004408.1	DSP_DUSP1	174..324	CDD:350486	67/178 (38%)
Mkp3	NP_001262031.1	DSP_MapKP	8..148	CDD:238723	35/127 (28%)
		DSPc	215..353	CDD:238073	59/137 (43%)
		CDC14	<242..359	CDD:225297	52/116 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2281
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.940