DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Osmr and Nrg

DIOPT Version :9

Sequence 1:NP_035149.2 Gene:Osmr / 18414 MGIID:1330819 Length:971 Species:Mus musculus
Sequence 2:NP_001245581.1 Gene:Nrg / 31792 FlyBaseID:FBgn0264975 Length:1309 Species:Drosophila melanogaster


Alignment Length:822 Identity:164/822 - (19%)
Similarity:278/822 - (33%) Gaps:263/822 - (31%)


- Green bases have known domain annotations that are detailed below.


Mouse    36 IHKVSFQLKLQEVNLEWTVPALTHEELNMIFQIEISRLNISNTIWVEN-----YSTTVKREEAVR 95
            ::.|.:..|..|:       |...|:..::|:...:.:......|:.|     .||...|     
  Fly   335 VNSVPYFTKEPEI-------ATAAEDEEVVFECRAAGVPEPKISWIHNGKPIEQSTPNPR----- 387

Mouse    96 WNWTSDIPLECVKHFIRIRALVDDT---KSLPQSSWGNWSS---------WKEVNAKVSVEPDKS 148
                              |.:.|:|   .:|.:...||:..         :|:|...|..||...
  Fly   388 ------------------RTVTDNTIRIINLVKGDTGNYGCNATNSLGYVYKDVYLNVQAEPPTI 434

Mouse   149 LIFPKDKVLEEGSNVTI-CLMYGQ----------------NVYNVSCKLQDEPIHGEQLDSHVSL 196
            ...|......:|.|||| |.:.|.                ..|||..       :|:        
  Fly   435 SEAPAAVSTVDGRNVTIKCRVNGSPKPLVKWLRASNWLTGGRYNVQA-------NGD-------- 484

Mouse   197 LKLNNVVFLSDTGTNINCQATKGPKRIFGTV-----LFV---SKVLEEPKNVSCETRDFKTLDCS 253
            |::.:|.| ||.| ...|.|    :..||.:     |.|   :::.:||:|.........|..|:
  Fly   485 LEIQDVTF-SDAG-KYTCYA----QNKFGEIQADGSLVVKEHTRITQEPQNYEVAAGQSATFRCN 543

Mouse   254 WEPGVDTTLT-----WRKQRFQNYTLCESFSKRCEVSNYRNSYTWQITEGSQEMYNFTLTAENQL 313
              ...|.||.     |:..:..::.....|.|..: ::...:.|.::..|     .:|..|..:|
  Fly   544 --EAHDDTLEIEIDWWKDGQSIDFEAQPRFVKTND-NSLTIAKTMELDSG-----EYTCVARTRL 600

Mouse   314 RKRSVNINFNLTHRVHPKAPQDVTLKIIGAT----KANMTWKVHSHGNNYTLLCQVKLQYGEVIH 374
            .:.:...  ||..:..|.||     |:.|.|    ||.:.|:  ..|:|.:.:....:|:     
  Fly   601 DEATARA--NLIVQDVPNAP-----KLTGITCQADKAEIHWE--QQGDNRSPILHYTIQF----- 651

Mouse   375 EHNVSVHMSANYLFSDLDPDTKYK-------AFVRCASANHFWKWSDWT------QKEFSTPETA 426
                      |..|:....|..|:       :||...|     .|:::|      .|..::|.:|
  Fly   652 ----------NTSFTPASWDAAYEKVPNTDSSFVVQMS-----PWANYTFRVIAFNKIGASPPSA 701

Mouse   427 PSQALDVWRQVWSENGRRIVTLFWKPLLKSQANGKIISYNIVVENEAKPTESEHYCVW---APAL 488
            .|.:......|..:|...:|....:|      |..:||:..:.|.|.......:|..|   .||.
  Fly   702 HSDSCTTQPDVPFKNPDNVVGQGTEP------NNLVISWTPMPEIEHNAPNFHYYVSWKRDIPAA 760

Mouse   489 S-----------TNLSLDLQP----YKIRITANNSMGASPESLMVLSNDSGHEEVKEK----TIK 534
            :           .|:.:..||    |.|::.|.|..|.|..:...:...||.:...:.    |::
  Fly   761 AWENNNIFDWRQNNIVIADQPTFVKYLIKVVAINDRGESNVAAEEVVGYSGEDRPLDAPTNFTMR 825

Mouse   535 GIKDAFN--ISWEPVS-----GDTMGYVVDWCAHSQDQRCDLQWKNLGPNTTSTTITSDDFKPGV 592
            .|..:.:  ::|.|||     |...||.:.                        |.|.::.:.|:
  Fly   826 QITSSTSGYMAWTPVSEESVRGHFKGYKIQ------------------------TWTENEGEEGL 866

Mouse   593 RYNFRIFERSVEHKARLVE---KQRGYTQELA-------PLVNPKVEIPYSTP------------ 635
            |   .|..:...|.|.:.:   ..:.|.:.||       |   |...|.:.||            
  Fly   867 R---EIHVKGDTHNALVTQFKPDSKNYARILAYNGRFNGP---PSAVIDFDTPEGVPSPVQGLDA 925

Mouse   636 -----NSFVLRW--PDYDSDFQAGFIKGYLVYVKSKEMQCNQPWERTLLPDNSVLCKYD--INGS 691
                 ::|:|.|  |.|.:    |.:.||.:|.  :|::.:...||.         :||  |...
  Fly   926 YPLGSSAFMLHWKKPLYPN----GKLTGYKIYY--EEVKESYVGERR---------EYDPHITDP 975

Mouse   692 ETKTLTVENLQPESLYEFFVTPYTSAGPGPNETFTKVTTPDA 733
            ....:.:..|:|.|.|...:|..|..|.|......|.|..||
  Fly   976 RVTRMKMAGLKPNSKYRISITATTKMGEGSEHYIEKTTLKDA 1017

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
OsmrNP_035149.2 LIFR_D2 30..137 CDD:375455 18/117 (15%)
fn3 332..413 CDD:394996 18/91 (20%)
WSXWS motif. /evidence=ECO:0000250 412..416 1/3 (33%)
FN3 437..512 CDD:214495 21/92 (23%)
FN3 622..730 CDD:238020 29/128 (23%)
Box 1 motif. /evidence=ECO:0000250 767..775
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 949..971
NrgNP_001245581.1 Ig 55..128 CDD:299845
IG_like 57..127 CDD:214653
Ig 135..214 CDD:299845
IG_like 141..216 CDD:214653
ig 251..332 CDD:278476
I-set 339..427 CDD:254352 18/117 (15%)
Ig 354..427 CDD:299845 14/95 (15%)
I-set 432..517 CDD:254352 23/105 (22%)
Ig 446..517 CDD:299845 22/91 (24%)
I-set 522..611 CDD:254352 18/98 (18%)
ig 525..609 CDD:278476 16/93 (17%)
FN3 613..707 CDD:238020 25/120 (21%)
FN3 716..807 CDD:238020 21/96 (22%)
fn3 817..905 CDD:278470 20/117 (17%)
FN3 917..1004 CDD:238020 22/101 (22%)
FN3 1041..1111 CDD:238020
Bravo_FIGEY 1155..>1221 CDD:290593
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
00.000

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