DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Slc22a6 and SLC22A

DIOPT Version :9

Sequence 1:	NP_032792.2	Gene:	Slc22a6 / 18399	MGIID:	892001	Length:	545	Species:	Mus musculus
Sequence 2:	NP_649370.1	Gene:	SLC22A / 40437	FlyBaseID:	FBgn0037140	Length:	568	Species:	Drosophila melanogaster

Alignment Length:	567	Identity:	143/567 - (25%)
Similarity:	238/567 - (41%)	Gaps:	92/567 - (16%)

- Green bases have known domain annotations that are detailed below.

Mouse     6 LLKQVGGVGRFQLIQVTMVVAPLLLMASHNTLQNFTAAIPAHHCRPPANANLSKDGGLEAWLPLD 70
            :||.:|..||||||...::..|::..|..:....||||...|.|...           |..||..
  Fly    30 ILKHLGQFGRFQLIIFLLICLPMMFHAMFSVTYVFTAATVTHRCSVE-----------ECDLPGS 83

Mouse    71 KQGRPESCLRFPFPHNGTEANGTGVTEPCLDGWVYDNSTFPSTIVTEWN---------------L 120
            ....|.:  .:..|.||.:.:...         .|.||..|     :||               .
  Fly    84 NYYEPHT--NWSIPKNGKDLDSCN---------RYTNSELP-----QWNHSVDICSADHFTKNKE 132

Mouse   121 VCSHRAF----RQLAQS------------LFMVGVL------LGAMMFGYLADRLGRRKVLILNY 163
            .|:|..|    .::..|            |.|||.:      .|..:.|::|||.||...:.|..
  Fly   133 ACAHNEFVFRDDEVTISNDFGIFCDDEWKLSMVGTINNLGQFFGIPIGGFVADRYGRSFSIALGG 197

Mouse   164 LQTAVSGTCAAYAPNYTVYCIFRLLSGMSLASIAINCMTLNMEWMPIHTRAYVGTLIGYVYSLGQ 228
            :..||.|...:::|:|..:.:|..|..|:.:::...|..:.:|.:....|....::|...|::|:
  Fly   198 ILGAVLGVIRSFSPSYGWFLVFEFLDNMTSSTLYSTCFVIGIELVGPKRRVLACSVITVFYAVGE 262

Mouse   229 FLLAGIAYAVPHWRHLQLAVSVPFFVAFIYSWFFIESARWYSSSGRLDLTLRALQRVARINGKQE 293
            .|||..|.|...||.|......|..:...|.|...||.||..|.|:.:.....|:|.|.:|.:
  Fly   263 VLLAMSAKAFHDWRILLRITYGPSLILLAYFWILPESVRWLLSQGKEERAKNILRRAAHVNKR-- 325

Mouse   294 EGAKLSIEVLQTSLQKELTLNKGQASAMELLRCPTLRRLFL--------CLSMLWFATSFAYYGL 350
                   |:.::.|.|.:..|:.:.......|.| :|..|.        | |:.|......||||
  Fly   326 -------ELPESVLDKLVLANRDKLQQSSESRFP-IREAFKNFKWRIANC-SLCWIVHVLVYYGL 381

Mouse   351 VMDLQGFGVSMYLIQVIFGAVDLPAKFVCFLVINSMGRRPAQLASLLLAGICILVNGIIPRG--H 413
            .:::.......|........|::|..|:..|:::..|||.:....:|.:|:|.:  |.|..|  .
  Fly   382 SLNVVLLDGDKYNNFAYIALVEIPGFFMPLLIMDRFGRRYSLCGLMLASGLCCI--GTIFTGADQ 444

Mouse   414 TIIRTSLAVLGKGCLASSFNCIFLYTGELYPTMIRQTGLGMGSTMARVGSIVSPLISMTAEFYPS 478
            .:::..|.::||..:.:||..::.:..|:|||.:|.:.|...|.|.|.||:::|...:.|::|.:
  Fly   445 PVLQLVLFLVGKLTITASFQVLYFFASEIYPTNLRNSLLSFCSMMGRFGSMLAPQTPLLAKYYAN 509

Mouse   479 IPLFIFGAVPVAASAVTALLPETLGQPLPDTVQD-----LKSRSRGK 520
            .|..:|....:.:..:|...|||....||.|||:     :|.:|:.|
  Fly   510 APAMLFAGAAIVSGLLTLFFPETTNVVLPTTVQEADAIGVKKQSKSK 556

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Slc22a6	NP_032792.2	2A0119	11..509	CDD:273328	135/544 (25%)
		MFS	129..499	CDD:119392	99/397 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	515..545		2/6 (33%)
SLC22A	NP_649370.1	2A0119	35..540	CDD:273328	135/544 (25%)
SLC22A	NP_649370.1	MFS	146..530	CDD:119392	99/396 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167844033
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.960