DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Slc22a6 and CG33233

DIOPT Version :9

Sequence 1:	NP_032792.2	Gene:	Slc22a6 / 18399	MGIID:	892001	Length:	545	Species:	Mus musculus
Sequence 2:	NP_995978.2	Gene:	CG33233 / 2769005	FlyBaseID:	FBgn0053233	Length:	489	Species:	Drosophila melanogaster

Alignment Length:	464	Identity:	96/464 - (20%)
Similarity:	167/464 - (35%)	Gaps:	122/464 - (26%)

- Green bases have known domain annotations that are detailed below.

Mouse    95 VTEPCLDGWVYDNSTFPSTIVTEWNLVCSHRAFRQLAQSLFMVGVLLGAMMFGYLADRLGRRKVL 159
            |||....|::        .::|......|.:....||.|| :.|::...:..|:||||.||:.|:
  Fly    34 VTESMTAGYL--------VVLTSCEFDTSPKEKTLLANSL-LGGMVASGLFIGFLADRYGRKFVI 89

Mouse   160 ILNYLQTAVSGTCAAYAPNYTVYCIFRLLSGMSLASIAINCMTLN---------MEWMPIHTRAY 215
            .|..:........:|..|:.....:.|::.|..|:::|    :|.         ::|.|| |.|.
  Fly    90 RLALVGALSFSVISALMPDLYSLSVIRIIVGTFLSAVA----SLQVGFLGEFHAIKWRPI-TVAI 149

Mouse   216 V----GTLIGYVYSLGQFLL-------AGIAYAVPHWRHLQLAVSVPFFVAFIYSWFFIESARWY 269
            .    |..:.|...:...:|       ...:|.:..||.|.:...:|.::|.:......|:..:.
  Fly   150 CSQSQGLALIYCPLVAMAILPNNFNVDLSSSYNLRVWRFLMMFFMIPGWLALVGICLVPETPHFL 214

Mouse   270 SSSGRLDLTLRALQRVARINGKQEEGAKLSIEVLQTSLQKELTLNKGQASAME------------ 322
            .|..|.|..|.||:.:.|:|.|:.|..             ::||::.::|..:
  Fly   215 MSVNRPDKALLALKWICRMNRKKWEDV-------------DITLSEEKSSTNDQEGFWKTVWYEY 266

Mouse   323 --LLRCPTLRRLFLCLSMLWFATSFAYYGLVMDLQGFGVSMYLIQVIFGAVDLPAKFVCFLVINS 385
              |...|.:.:.|:||        |..:|:.....|.|                   :.|.||.:
  Fly   267 KLLFSKPHVFKFFICL--------FLIFGIFFTSIGLG-------------------IWFPVIRN 304

Mouse   386 MGRRPAQLASLLLAGICILVNGIIPRGHTIIRTSLAVLGKGCLASSFNCIFLYTGELYPTMIRQT 450
            |....:.       .:|.|||    ...|.|... |....|..:.|..|....|..:.|.....|
  Fly   305 MDNSGSN-------RLCDLVN----NNPTFINHE-ADDTNGTDSESPKCNDEMTNLIDPVYYGFT 357

Mouse   451 GLG---MGSTMAR---------VGSIVSPL--ISMTAEFYPSIPLFIF-------GA-VPVAASA 493
            .:|   :.|.:..         :..::|.:  ||:.....|::.|..|       |. :|:|.|.
  Fly   358 YIGCFILASVLVHWMTRKYVIALHILISMILGISLNIMKQPTVVLIFFVLMMVLPGVLIPLATSV 422

Mouse   494 VTALLPETL 502
            :...||..|
  Fly   423 LVDCLPVNL 431

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Slc22a6	NP_032792.2	2A0119	11..509	CDD:273328	96/464 (21%)
		MFS	129..499	CDD:119392	87/425 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	515..545
CG33233	NP_995978.2	MFS_1	22..451	CDD:284993	96/464 (21%)
		MFS	23..>208	CDD:119392	41/187 (22%)
		MFS	354..>482	CDD:304372	16/78 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167843506
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930