DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kvs-2 and Shawl

DIOPT Version :9

Sequence 1:	NP_001256236.1	Gene:	kvs-2 / 183120	WormBaseID:	WBGene00007862	Length:	575	Species:	Caenorhabditis elegans
Sequence 2:	NP_001097131.2	Gene:	Shawl / 5740840	FlyBaseID:	FBgn0085395	Length:	937	Species:	Drosophila melanogaster

Alignment Length:	534	Identity:	144/534 - (26%)
Similarity:	233/534 - (43%)	Gaps:	133/534 - (24%)

- Green bases have known domain annotations that are detailed below.

Worm    92 GESRSTTITHDSGSNADTYMRLNVGGKSYYVRAELYTSEWTRMHELLDSSHEERLKMVDGFDSKT 156
            ||:|  .|.:.||...:||            :|.|.....||:..|.::        :..:|...
  Fly     3 GENR--IILNVSGIRYETY------------KATLKKIPATRLSRLTEA--------LANYDPVL 45

Worm   157 GEYYLERNAKLTDHVMDFFVTGSLHKPQNVCVERFKEELEYWKIKPDQLSTCC------------ 209
            .||:.:|:..:...:::::.||.||.|.:||...|:||||:|.:..:|:..||
  Fly    46 NEYFFDRHPGVFTQILNYYRTGKLHYPTDVCGPLFEEELEFWGLDSNQVEPCCWSTYSIHRDTQN 110

Worm   210 ------------QIPSEHHVRKLSRGTSFNEDDYVTDFDGACFAGPRLAMWKFLEDPQSSVFAAV 262
                        :.|:|..:.:|     |..::.:::.:..|:...:..:|...::|.||..|.:
  Fly   111 TLAILDKLDIENEKPTEEQIARL-----FGFEEALSNGELNCWQRIKPKIWAMFDEPSSSTGAKI 170

Worm   263 FALLSVFFVFASVVGLILGSMPEFQADSSNAA----------------------TYHVMHVRS-- 303
            .|.:||||:|.||:...|.:.|.|:.|..:.|                      ..|..|..|
  Fly   171 VAGMSVFFIFVSVISFCLKTHPGFRVDLPSGAHDAHGPGAGGPPHGHDPMGEPPQTHQYHQHSIT 235

Worm   304 ----------RPNDY-----GN-------------KFGNDDDVAPN---ELLKDFV--------- 328
                      |..:|     ||             |.|....:..|   .:|.:|:
  Fly   236 PPSGSIGPTFRVTNYTSYSSGNFTASGQATPIATIKGGQRQRLKRNINGSILNEFIEEKILGHNG 300

Worm   329 ------YKPTDSPNLPLTILEYICIGWFTFEYLVRFTIYPRKRQFVKKTLNIIDLSTILPFYLEI 387
                  .:....|:.....:|.:|..||..|.::|..:.|...||:|..:||||.:..|.||.:
  Fly   301 RRKHGWIETYGQPHEAFFYVELVCNVWFFIEVIIRLIVSPNLWQFIKSPVNIIDFTATLSFYTD- 364

Worm   388 CLPLFGVESRLKEFTGAMLVVRVLRVLRMARVFKLARYSTSLQTFGHTLQSSITELSMLSMFLIT 452
                  |..|:.|:||.:....::|::|:   |||.|:|..|:...||.::|..||::|..||:.
  Fly   365 ------VMQRMGEYTGLLEAFSIVRIMRL---FKLTRHSPGLRILIHTFKASAKELTLLVFFLVL 420

Worm   453 GIVFFSTIMYYLEK--DEPHTDFYSIPAGCWWCVVTMATVGYGDAKPVTTLGKLVATSTSICGII 515
            |||||:::.||.||  |.|...|.|||.|.||.:|||.||||||..|.|..|..|....::.|::
  Fly   421 GIVFFASLAYYAEKLQDNPDNQFKSIPLGLWWAIVTMTTVGYGDVAPKTYPGMFVGALCALAGVL 485

Worm   516 VLAFPISMIVEKFA 529
            .:|.|:.:||..|:
  Fly   486 TIALPVPVIVSNFS 499

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kvs-2	NP_001256236.1	BTB_POZ_Kv	111..199	CDD:349626	21/87 (24%)
kvs-2	NP_001256236.1	Ion_trans	329..535	CDD:366146	76/203 (37%)
Shawl	NP_001097131.2	BTB	7..99	CDD:197585	29/111 (26%)
		BTB_2	7..97	CDD:280393	28/109 (26%)
		Ion_trans	307..506	CDD:278921	76/203 (37%)
		Ion_trans_2	<449..499	CDD:285168	21/49 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D818306at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920