DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DSCAM and dpr21

DIOPT Version :9

Sequence 1:	NP_001380.2	Gene:	DSCAM / 1826	HGNCID:	3039	Length:	2012	Species:	Homo sapiens
Sequence 2:	NP_001163838.2	Gene:	dpr21 / 8674044	FlyBaseID:	FBgn0260995	Length:	282	Species:	Drosophila melanogaster

Alignment Length:	228	Identity:	54/228 - (23%)
Similarity:	90/228 - (39%)	Gaps:	46/228 - (20%)

- Green bases have known domain annotations that are detailed below.

Human   498 RINVRGP-ASIRPMKNITAIAGRDTYIHCRVIGYPYYSIKWYKNSNL---------LPFNHRQVA 552
            |:..||| ......||:|::.|...:::||:......::.|.::.:|         ...:.|..:
  Fly    45 RVLDRGPYFDTSATKNVTSLVGITGHLNCRIKNLGNKTVSWIRHRDLHLLTVSESTYTSDQRFTS 109

Human   553 FENNGT------LKLSDVQKEVDEGEYTCNVLVQPQLSTSQSVHVTVKVPPFIQPFEFPR--FSI 609
            ..|..|      :|...::   |.|.|.|.|...|.:..:....|   |.|.......|.  ..:
  Fly   110 IYNKQTGDWSLQIKFPQLR---DSGIYECQVSTTPPVGYTMVFSV---VEPITSILGGPEIYIDL 168

Human   610 GQRVFIPCVVVS-GDLPITITWQKDGRPI-----PGSLGVTIDNIDFTSS-LRISNLSLMHNGNY 667
            |..|.:.||:.. .|.||::.|..:.:.|     .|.:.|..:..|.|:| |.|...|:..:|.|
  Fly   169 GSTVNLTCVIKHLPDPPISVQWNHNNQEINYDSPRGGVSVITEKGDITTSYLLIQRASIADSGQY 233

Human   668 TCIARN--------------EAAAVEHQSQLIV 686
            ||:..|              ..|||: :|.|:|
  Fly   234 TCLPSNANSKSVNVHILKGDHPAAVQ-KSHLLV 265

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DSCAM	NP_001380.2	Ig	45..113	CDD:319273
		I-set	235..310	CDD:254352
		I-set	315..385	CDD:333254
		Ig_3	407..488	CDD:316449
		IGc2	518..575	CDD:197706	12/71 (17%)
		I-set	596..686	CDD:333254	29/112 (26%)
		Ig_DSCAM	707..784	CDD:143211
		Ig	802..889	CDD:325142
		FN3	885..978	CDD:238020
		FN3	986..1083	CDD:238020
		FN3	1091..1184	CDD:238020
		FN3	1189..1278	CDD:238020
		Ig	1303..1369	CDD:319273
		FN3	1380..1470	CDD:238020
		FN3	1486..1555	CDD:238020
		Required for netrin-mediated axon repulsion of neuronal growth cones. /evidence=ECO:0000250\|UniProtKB:Q9ERC8	1617..2012
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1718..1810
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1855..1883
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1971..2012
dpr21	NP_001163838.2	Ig	71..149	CDD:299845	14/80 (18%)
		IG_like	71..140	CDD:214653	13/71 (18%)
		IG_like	162..249	CDD:214653	23/86 (27%)
		IGc2	169..242	CDD:197706	22/72 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910