DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DSCAM and dscama

DIOPT Version :9

Sequence 1:	NP_001380.2	Gene:	DSCAM / 1826	HGNCID:	3039	Length:	2012	Species:	Homo sapiens
Sequence 2:	XP_021334866.1	Gene:	dscama / 568643	ZFINID:	ZDB-GENE-050310-7	Length:	2025	Species:	Danio rerio

Alignment Length:	2030	Identity:	1588/2030 - (78%)
Similarity:	1792/2030 - (88%)	Gaps:	23/2030 - (1%)

- Green bases have known domain annotations that are detailed below.

Human     1 MWILALSLFQSFANVFSEDLHSSLYFVNASLQEVVFASTTGTLVPCPAAGIPPVTLRWYLATGEE 65
            |||||:..||...||.|||||||||||||||||||||||||||||||||.:||.|||||||||||
Zfish     1 MWILAIIFFQCILNVLSEDLHSSLYFVNASLQEVVFASTTGTLVPCPAAAVPPATLRWYLATGEE 65

Human    66 IYDVPGIRHVHPNGTLQIFPFPPSSFSTLIHDNTYYCTAENPSGKIRSQDVHIKAVLREPYTVRV 130
            .|:||||||||||||||||.|||||||.:||||||||||||||||||||||||||||||||||||
Zfish    66 SYNVPGIRHVHPNGTLQIFHFPPSSFSKVIHDNTYYCTAENPSGKIRSQDVHIKAVLREPYTVRV 130

Human   131 EDQKTMRGNVAVFKCIIPSSVEAYITVVSWEKDTVSLVSGSRFLITSTGALYIKDVQNEDGLYNY 195
            .||..|||:|||||||||||||.||||||||:|||.||||:||||||||||||.|||.||.|:||
Zfish   131 ADQTAMRGSVAVFKCIIPSSVENYITVVSWERDTVPLVSGARFLITSTGALYILDVQKEDELFNY 195

Human   196 RCITRHRYTGETRQSNSARLFV-SDPANSAPSILDGFDHRKAMAGQRVELPCKALGHPEPDYRWL 259
            ||:||||||.|||||||||||| :||:||||:|||||:.|:.||..||||||||.|||.|.||||
Zfish   196 RCMTRHRYTSETRQSNSARLFVPADPSNSAPAILDGFEKREVMASHRVELPCKASGHPAPKYRWL 260

Human   260 KDNMPLELSGRFQKTVTGLLIENIRPSDSGSYVCEVSNRYGTAKVIGRLYVKQPLKATISPRKVK 324
            |:|.|||...||:::|||||||..:|||:|||||||.|.||.|:|||||.||:||||.:||||||
Zfish   261 KNNRPLESDSRFRQSVTGLLIERAQPSDTGSYVCEVWNSYGNAEVIGRLTVKEPLKAVVSPRKVK 325

Human   325 SSVGSQVSLSCSVTGTEDQELSWYRNGEILNPGKNVRITGINHENLIMDHMVKSDGGAYQCFVRK 389
            .||||||||||||||:::.||||||||:.:|.|.|:|:.|||.|||:||.|.|||||.||||.||
Zfish   326 GSVGSQVSLSCSVTGSDEFELSWYRNGDKINTGANIRMNGINKENLVMDGMAKSDGGVYQCFSRK 390

Human   390 DKLSAQDYVQVVLEDGTPKIISAFSEKVVSPAEPVSLMCNVKGTPLPTITWTLDDDPILKGGSHR 454
            .|:||||:|||:||||||||:||||||||.|.:.|||.|:|||||.|.|||||||:.:.|...||
Zfish   391 AKMSAQDFVQVILEDGTPKILSAFSEKVVGPNDFVSLTCHVKGTPQPAITWTLDDEVVAKDSRHR 455

Human   455 ISQMITSEGNVVSYLNISSSQVRDGGVYRCTANNSAGVVLYQARINVRGPASIRPMKNITAIAGR 519
            |...||:|||||||||||..||||.||||||.|||||.|.|||||||||.|.||||||:|||||.
Zfish   456 IVHSITAEGNVVSYLNISHIQVRDSGVYRCTCNNSAGTVSYQARINVRGSADIRPMKNLTAIAGW 520

Human   520 DTYIHCRVIGYPYYSIKWYKNSNLLPFNHRQVAFENNGTLKLSDVQKEVDEGEYTCNVLVQPQLS 584
            |.||||.|||||||||||:|||||||||.||.||||||||||.:||||:|||||:|:|.|||||.
Zfish   521 DMYIHCHVIGYPYYSIKWFKNSNLLPFNDRQRAFENNGTLKLLNVQKELDEGEYSCHVQVQPQLF 585

Human   585 TSQSVHVTVKVPPFIQPFEFPRFSIGQRVFIPCVVVSGDLPITITWQKDGRPIPGSLGVTIDNID 649
            .:||||||||||||||||||||:|||.|||:||||.||||||:|||:|||:.|..||||||||||
Zfish   586 KNQSVHVTVKVPPFIQPFEFPRYSIGHRVFVPCVVRSGDLPISITWEKDGKSINASLGVTIDNID 650

Human   650 FTSSLRISNLSLMHNGNYTCIARNEAAAVEHQSQLIVRVPPKFVVQPRDQDGIYGKAVILNCSAE 714
            ||||||||||..:|||.|||||:|:||.|::||||||||||:|.|||:||||||||:|||||||:
Zfish   651 FTSSLRISNLQRVHNGTYTCIAQNDAAVVKYQSQLIVRVPPRFKVQPQDQDGIYGKSVILNCSAD 715

Human   715 GYPVPTIVWKFSKGAGVPQFQPIALNG--RIQVLSNGSLLIKHVVEEDSGYYLCKVSNDVGADVS 777
            |.|.|||.||:|||||||||||||||.  |:|:|.|||||||||:|||:||||||||||||||||
Zfish   716 GEPRPTIEWKYSKGAGVPQFQPIALNSGFRVQLLGNGSLLIKHVLEEDAGYYLCKVSNDVGADVS 780

Human   778 KSMYLTVKIPAMITSYPNTTLATQGQKKEMSCTAHGEKPIIVRWEKE------DRIINPEMARYL 836
            |||||.||||||||||||.:|||:|:|.||||.|||||||:||||||      ..:|||:|.|:.
Zfish   781 KSMYLNVKIPAMITSYPNNSLATKGEKIEMSCKAHGEKPIMVRWEKEVEKEKQSHMINPDMWRHT 845

Human   837 VSTKEVGEEVISTLQILPTVREDSGFFSCHAINSYGEDRGIIQLTVQEPPDPPEIEIKDVKARTI 901
            |:.|.||:||:|||||.||:|||||||||||||||||||||:||||||||:||::||::||.|||
Zfish   846 VTVKNVGDEVVSTLQIYPTMREDSGFFSCHAINSYGEDRGILQLTVQEPPEPPKVEIREVKERTI 910

Human   902 TLRWTMGFDGNSPITGYDIECKNKSDSWDSAQRTKDVSPQLNSATIIDIHPSSTYSIRMYAKNRI 966
            .|||||||||||.|||||||||||:::|:.|:||:||||.||.||||::||||||:|||:|||.|
Zfish   911 ALRWTMGFDGNSLITGYDIECKNKTETWERARRTRDVSPTLNQATIIELHPSSTYNIRMFAKNHI 975

Human   967 GKSEPSNELTITADEAAPDGPPQEVHLEPISSQSIRVTWKAPKKHLQNGIIRGYQIGYREYSTGG 1031
            |.||||||||:|.|||.|:||||:|.||.|:||||:||||||.||||||:|||||:.:||:||.|
Zfish   976 GDSEPSNELTVTTDEADPEGPPQDVTLEAITSQSIKVTWKAPLKHLQNGVIRGYQVCHREHSTNG 1040

Human  1032 NFQFNIISVDTSGDSEVYTLDNLNKFTQYGLVVQACNRAGTGPSSQEIITTTLEDVPSYPPENVQ 1096
            :.||..|||:.:|::|..:|:||.||.:|.:||||.|.||.||:|.|:..||:|||||..||.|.
Zfish  1041 SHQFVCISVEATGETESLSLNNLKKFAEYEVVVQASNSAGPGPASSEVRATTMEDVPSRAPEKVV 1105

Human  1097 AIATSPESISISWSTLSKEALNGILQGFRVIYWANLMDGELGEIKNITTTQPSLELDGLEKYTNY 1161
            |.|.||||||:||.|.::|||||:|||||:||||||.|||||||:|:||.:..|||:||||||||
Zfish  1106 ATAASPESISLSWQTPAREALNGVLQGFRIIYWANLPDGELGEIRNVTTHKAPLELEGLEKYTNY 1170

Human  1162 SIQVLAFTRAGDGVRSEQIFTRTKEDVPGPPAGVKAAAASASMVFVSWLPPLKLNGIIRKYTVFC 1226
            ||||||||||||||||:||:.||||||||||.||||||||:|:|:|||||||||||:||||||||
Zfish  1171 SIQVLAFTRAGDGVRSDQIYIRTKEDVPGPPGGVKAAAASSSVVYVSWLPPLKLNGVIRKYTVFC 1235

Human  1227 SHPYPTVISEFEASPDSFSYRIPNLSRNRQYSVWVVAVTSAGRGNSSEIITVEPLAKAPARILTF 1291
            |...|||:||||.:||.|.:|:.||||||:|::||:|||:|||||||::|||||||||||:||||
Zfish  1236 SSTSPTVVSEFEVAPDEFLHRVHNLSRNRKYNIWVMAVTAAGRGNSSDVITVEPLAKAPAKILTF 1300

Human  1292 SGTVTTPWMKDIVLPCKAVGDPSPAVKWMKDSNGTPSLVTIDGRRSIFSNGSFIIRTVKAEDSGY 1356
            |||||||||:|:||||:|||||.||:||:|:| |:|:...|||||||..||||||:|||||||||
Zfish  1301 SGTVTTPWMRDVVLPCRAVGDPPPAIKWLKES-GSPAPAVIDGRRSIHGNGSFIIKTVKAEDSGY 1364

Human  1357 YSCIANNNWGSDEIILNLQVQVPPDQPRLTVSKTTSSSITLSWLPGDNGGSSIRGYILQYSEDNS 1421
            |:|:|:||:|:||||||||||||||||||||:|||::|||::|.|||||||||||||||||||||
Zfish  1365 YTCVASNNYGTDEIILNLQVQVPPDQPRLTVTKTTTTSITVTWTPGDNGGSSIRGYILQYSEDNS 1429

Human  1422 EQWGSFPISPSERSYRLENLKCGTWYKFTLTAQNGVGPGRISEIIEAKTLGKEPQFSKEQELFAS 1486
            |:|||..|||||||||||||.|||||||||||||.||||||||||||||.|||||||||||||.|
Zfish  1430 EKWGSISISPSERSYRLENLNCGTWYKFTLTAQNAVGPGRISEIIEAKTHGKEPQFSKEQELFTS 1494

Human  1487 INTTRVRLNLIGWNDGGCPITSFTLEYRPFGTTVWTTAQRTSLSKSYILYDLQEATWYELQMRVC 1551
            ||.|.|:||||||||||||||||||||||..:.|||.|:||||||||.|.||||||||||||:|.
Zfish  1495 INGTSVKLNLIGWNDGGCPITSFTLEYRPLESPVWTKAKRTSLSKSYNLLDLQEATWYELQMKVY 1559

Human  1552 NSAGCAEKQANFATLNYDGSTIPPLIKSVVQNEEGLTTNEGLKMLVTISCILVGVLLLFVLLLVV 1616
            ||||.|||:..||||:|||||||||:|::|::....|:|||:||:|||||||||::||||||:|:
Zfish  1560 NSAGLAEKRVKFATLSYDGSTIPPLVKTLVKDPVKKTSNEGMKMMVTISCILVGMVLLFVLLMVL 1624

Human  1617 RRRRREQRLKRLRDAKSLAEMLMSKNTRTSDTLSKQQQTLRMHIDIPRAQLLIEERDTMETIDDR 1681
            ||||||||||||||||||||||||||||.|||::|||||||||||||||||||||||||||:|||
Zfish  1625 RRRRREQRLKRLRDAKSLAEMLMSKNTRPSDTMNKQQQTLRMHIDIPRAQLLIEERDTMETVDDR 1689

Human  1682 STVLLTDADFGEAAKQKSLTVTHTVHYQSVSQATGPLVDVSDARPGT------NPTTRRNAKAGP 1740
            |||||||.||||.|||||.||||:|||||:||||||||||||.||||      |||:||.|||||
Zfish  1690 STVLLTDNDFGETAKQKSATVTHSVHYQSLSQATGPLVDVSDVRPGTSKSSLSNPTSRRTAKAGP 1754

Human  1741 TARNRYASQWTLNRPHPTISAHTLTTDWRLPTPRAAGSVDKESDSYSVSPSQDTDRARSSMVSTE 1805
            .||||||||||||||||.:|.|||:|||||.|||.||||||||||||||||||||||||||||||
Zfish  1755 AARNRYASQWTLNRPHPPVSVHTLSTDWRLGTPRVAGSVDKESDSYSVSPSQDTDRARSSMVSTE 1819

Human  1806 SASSTYEELARAYEHAKMEEQLRHAKFTITECFISDTSSEQLTAGTNEYTDSLTSSTPSESGICR 1870
            |||||||||||||||||||||||||||||||||||||||||:|||||:|||||||||||||||||
Zfish  1820 SASSTYEELARAYEHAKMEEQLRHAKFTITECFISDTSSEQMTAGTNDYTDSLTSSTPSESGICR 1884

Human  1871 FTASPPKPQDGGRVMNMAVPKAHRP-GDLIHLPPYLRMDFLLNRGGPGTSRDLSLGQACLEPQKS 1934
            ||||||||||..||:|||||||||| |:|:|||||||||||||||..||||:.::|||||||||:
Zfish  1885 FTASPPKPQDVCRVINMAVPKAHRPGGELVHLPPYLRMDFLLNRGVSGTSREAAMGQACLEPQKT 1949

Human  1935 RTLKRPTVLEPIPMEAASSASSTREGQSWQPGAVATLPQRE-GAELGQAAKMSSSQESLLDSRGH 1998
            |:||||.:|||.|||..:|    |:.|.||.|..:|||||| |.:|.||||:|:|||||||||||
Zfish  1950 RSLKRPALLEPTPMEVPTS----RDVQQWQSGTASTLPQREAGTDLAQAAKISTSQESLLDSRGH 2010

Human  1999 LK-GNNPYAKSYTLV 2012
            || .|||||||||||
Zfish  2011 LKQTNNPYAKSYTLV 2025

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DSCAM	NP_001380.2	Ig	45..113	CDD:319273	59/67 (88%)
		I-set	235..310	CDD:254352	51/74 (69%)
		I-set	315..385	CDD:333254	49/69 (71%)
		Ig_3	407..488	CDD:316449	56/80 (70%)
		IGc2	518..575	CDD:197706	47/56 (84%)
		I-set	596..686	CDD:333254	70/89 (79%)
		Ig_DSCAM	707..784	CDD:143211	65/78 (83%)
		Ig	802..889	CDD:325142	66/92 (72%)
		FN3	885..978	CDD:238020	69/92 (75%)
		FN3	986..1083	CDD:238020	58/96 (60%)
		FN3	1091..1184	CDD:238020	69/92 (75%)
		FN3	1189..1278	CDD:238020	65/88 (74%)
		Ig	1303..1369	CDD:319273	45/65 (69%)
		FN3	1380..1470	CDD:238020	78/89 (88%)
		FN3	1486..1555	CDD:238020	55/68 (81%)
		Required for netrin-mediated axon repulsion of neuronal growth cones. /evidence=ECO:0000250\|UniProtKB:Q9ERC8	1617..2012		337/403 (84%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1718..1810		81/97 (84%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1855..1883		26/27 (96%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1971..2012		34/42 (81%)
dscama	XP_021334866.1	Ig	124..217	CDD:325142	78/92 (85%)
		I-set	236..311	CDD:254352	51/74 (69%)
		IG_like	321..402	CDD:214653	58/80 (73%)
		I-set	408..502	CDD:333254	67/93 (72%)
		IGc2	524..579	CDD:197706	45/54 (83%)
		Ig	614..679	CDD:319273	50/64 (78%)
		Ig_DSCAM	708..787	CDD:143211	65/78 (83%)
		Ig	805..898	CDD:325142	66/92 (72%)
		FN3	894..988	CDD:238020	69/93 (74%)
		FN3	995..1092	CDD:238020	58/96 (60%)
		fn3	1100..1186	CDD:306538	65/85 (76%)
		fn3	1199..1282	CDD:306538	61/82 (74%)
		Ig	1312..1377	CDD:319273	45/65 (69%)
		fn3	1405..1471	CDD:306538	57/65 (88%)
		FN3	1492..1563	CDD:238020	56/70 (80%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C194342332
Domainoid	1	1.000	894	1.000	Domainoid score	I597
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H74393
Inparanoid	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG47134
OrthoDB	1	1.010	-	-		D10185at33208
OrthoFinder	1	1.000	-	-		FOG0003568
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101656
Panther	1	1.100	-	-	O	PTHR10075
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4969
SonicParanoid	1	1.000	-	-		X1391
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	1	1.500	-	-
	16	16.250