DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DSCAM and dpr12

DIOPT Version :9

Sequence 1:	NP_001380.2	Gene:	DSCAM / 1826	HGNCID:	3039	Length:	2012	Species:	Homo sapiens
Sequence 2:	NP_652462.3	Gene:	dpr12 / 50320	FlyBaseID:	FBgn0085414	Length:	326	Species:	Drosophila melanogaster

Alignment Length:	221	Identity:	57/221 - (25%)
Similarity:	87/221 - (39%)	Gaps:	42/221 - (19%)

- Green bases have known domain annotations that are detailed below.

Human   327 VGSQVSLSCSVTGTED-----QELSWYRNGE--ILNPGKN----------VRITGINHENLIMDH 374
            :|....|.|.|:|.:.     .::||.|..:  ||:.|..          :...|.|...|.:..
  Fly    91 LGGTAFLVCKVSGVDRVGVNWNQISWIRRRDWHILSSGAQLYTNDERFAILHTPGSNMWTLQIKF 155

Human   375 MVKSDGGAYQCFVRKDKLSAQDYV--QVVLEDGTPKIISAFSEKVVSPAEPVSLMCNVKGTPLPT 437
            :.:.|.|.|:|.|.........:|  |||:.:.   .|....|..|.....::|:|.::.:|.|.
  Fly   156 VQRRDHGMYECQVSTPTGIISHFVNLQVVVPEA---FILGSGELHVDMGSTINLVCIIEKSPTPP 217

Human   438 --ITWTLDDDPILKGGSHRISQMITSEG-NVVSYLNISSSQVRDGGVYRCTANNSAGVVLYQARI 499
              :.|..:|..|....|.|...:.|:.| ...|.|.|...||.|.|.|.|:|:|:.
  Fly   218 QYVYWQKNDRLINYVDSRRDITIETTPGPRTQSRLIIREPQVTDSGNYTCSASNTE--------- 273

Human   500 NVRGPASIRPM----KNITAIAGRDT 521
                ||||...    .|:.||:.|.|
  Fly   274 ----PASIYVFVSKGDNMAAISRRKT 295

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DSCAM	NP_001380.2	Ig	45..113	CDD:319273
		I-set	235..310	CDD:254352
		I-set	315..385	CDD:333254	17/74 (23%)
		Ig_3	407..488	CDD:316449	24/83 (29%)
		IGc2	518..575	CDD:197706	2/4 (50%)
		I-set	596..686	CDD:333254
		Ig_DSCAM	707..784	CDD:143211
		Ig	802..889	CDD:325142
		FN3	885..978	CDD:238020
		FN3	986..1083	CDD:238020
		FN3	1091..1184	CDD:238020
		FN3	1189..1278	CDD:238020
		Ig	1303..1369	CDD:319273
		FN3	1380..1470	CDD:238020
		FN3	1486..1555	CDD:238020
		Required for netrin-mediated axon repulsion of neuronal growth cones. /evidence=ECO:0000250\|UniProtKB:Q9ERC8	1617..2012
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1718..1810
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1855..1883
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1971..2012
dpr12	NP_652462.3	IG	86..183	CDD:214652	20/91 (22%)
		Ig_3	193..271	CDD:404760	23/77 (30%)
		Ig strand B	204..208	CDD:409353	1/3 (33%)
		Ig strand C	219..223	CDD:409353	0/3 (0%)
		Ig strand E	250..254	CDD:409353	2/3 (67%)
		Ig strand F	264..269	CDD:409353	2/4 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810