DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment DSCAM and tutl

DIOPT Version :10

Sequence 1:NP_001380.2 Gene:DSCAM / 1826 HGNCID:3039 Length:2012 Species:Homo sapiens
Sequence 2:NP_001303307.1 Gene:tutl / 46015 FlyBaseID:FBgn0010473 Length:1536 Species:Drosophila melanogaster


Alignment Length:1709 Identity:365/1709 - (21%)
Similarity:585/1709 - (34%) Gaps:465/1709 - (27%)


- Green bases have known domain annotations that are detailed below.


Human   406 TPKIISAFSEKVV------SPAEPVSLMCNVK----GTPLPTITWTLDDDPILKGGSHRISQMIT 460
            :|...:||:.|..      ..||..|:...::    .||.|||               ::.|.: 
  Fly    66 SPAKTAAFTVKTTRRRRSRRRAEGSSICVPIRRGQGSTPTPTI---------------QVLQFV- 114

Human   461 SEGNVVSYL-----NISSSQVRDGGVYRCTANNSAGVVLYQARINVRGPASIRPMKNI------T 514
                :||.|     |..:..:.:..|: .||....||:.   ..:|..| :..|:..:      .
  Fly   115 ----LVSLLALLAKNAQAHNIPEDAVH-ITAILGEGVIF---NCHVEFP-NDHPVPYVLQWDKKV 170

Human   515 AIAGRDTYIHCRVIGYPYYSIKWYKN-----SNLLPFNHRQVAFENNGTLKLSDVQKEVDEGEYT 574
            :..|.|..|:.....||.:..:.||.     |...||        .:.:|.|::: :|.|:|.|.
  Fly   171 SETGSDLPIYIWYESYPEHIEEGYKGRVSRVSQDSPF--------GSASLNLTNI-RESDQGWYE 226

Human   575 CNVLV----QPQLSTSQSVHVTVKVPP--FIQPFEFPRFSIGQRVFIPCVVVSGDLPITITWQKD 633
            |.|:.    ..|.......|:.|..||  .:.|.:....::|..:.:.|.......| .|.|.||
  Fly   227 CKVVFLNRDPKQHKNGTWFHLDVHAPPRFSVTPEDIIYVNLGDSIILNCQADGTPTP-EILWYKD 290

Human   634 GRPIPGSLGVTIDNIDFTSSLRISNLSLMHNGNYTCIARNEAAAVEHQSQLIVRVPPKFVVQPRD 698
            ..|:..|..|.|.| |.| .||||.:.....|.|||||||....|.|.:::|:......:|.|.:
  Fly   291 ANPVDPSPTVGIFN-DGT-ELRISTIRHEDIGEYTCIARNGEGQVSHTARVIIAGGAVIMVPPTN 353

Human   699 QDGIYGKAVILNCSAEGYPVPTIVWKFSKGAGVPQFQPIALNGRIQVLSNGSLLIKHVVEEDSGY 763
            |..:.|:.||.:|.|:..|....|..:.:|:  |..:..||..|:.:..:|||:|..:..:|||.
  Fly   354 QTKLEGEKVIFSCEAKAMPGNVTVRWYREGS--PVREVAALETRVTIRKDGSLIINPIKPDDSGQ 416

Human   764 YLCKVSNDVGADVSKSMYLTVKIPAMITSYPNTTLATQGQKKEMSCTAHGEKPI-IVRWEKEDRI 827
            |||:|:|.:|...|.|.||:|:.||.:|..|............:.|.......: .|.|.|:.|:
  Fly   417 YLCEVTNGIGDPQSASAYLSVEYPAKVTFTPTVQYLPFRLAGVVQCYIKSSPQLQYVTWTKDKRL 481

Human   828 INPEMARYLVSTKEVGEEVISTLQILPT-VRED-SGFFSCHAINSYGE--DRGIIQLTVQEPP-- 886
            :.|...:.:|        |::...:|.| |.|: .|.::|...|:.|.  ..|::.:.|::||  
  Fly   482 LEPYQMKDIV--------VMANGSLLFTRVNEEHQGQYACTPYNAQGTAGASGVMDVLVRKPPAF 538

Human   887 -------------DPPEIEIKDVKARTI---TLRWTMGFDGNSPITGYDIECKNKSDSWDSAQRT 935
                         |..|:....::|...   |::|.                :.:.:....:||.
  Fly   539 TVEPETLYQRKVGDSVEMHCDALEAEGTERPTIKWQ----------------RQEGEQLTESQRN 587

Human   936 KDVSPQLNSATIIDIHPSSTYSIRMYAKNRIGKSEPSNELTITADEAAPDGPPQEVHLEPISSQS 1000
            : :.....:.||.::........:....|.:.......:|.|...:  |..|             
  Fly   588 R-IKISGGNITIENLRREDFGYYQCVVSNEVATLMAVTQLVIEGTQ--PHAP------------- 636

Human  1001 IRVTWKAPKKHLQNGIIRGYQIG--YRE-----YSTGGNFQFNIISVDTSGDSEVYTLDNLNKFT 1058
            ..:|.||.:..:....:.||..|  |::     :...|...:..|||..||.::| |::.|...|
  Fly   637 YNITGKATESSITLQWLPGYSGGSEYKQDYTIWFREAGVNDWQTISVTPSGSTQV-TINGLASGT 700

Human  1059 QYGLVVQACNRAGTGPSSQEIITTTLEDVPSYPPENVQAIATSPESISISWSTLSKEALNGILQG 1123
            .|...|...|..|.|..|:.:...||||.|: .|.||:|....|:|.   :..:..||   .|..
  Fly   701 TYEFQVVGRNVLGDGMMSKVMTVRTLEDAPA-APRNVKAATQPPDSF---FQLMPDEA---DLLA 758

Human  1124 FRVIYWANLMDGELGEIKNITTTQPSLELDGLEKYTNYSIQVLAFTRAGDGVRSEQIFTRTKEDV 1188
            :..||:.....|.|      ..:.|.|                                |.|...
  Fly   759 YFDIYFHTDSRGTL------VYSPPKL--------------------------------RVKGPK 785

Human  1189 PGPPAGVKAAAASASMVFVSWLPPLKLNGIIRKYTVFCSHPYPT-----VISEFEASPDSFSYRI 1248
            ||||..|.....|...: ::|..||:...|::.||:    .|.|     .::..:..|:...|.:
  Fly   786 PGPPRNVSVTEVSNGFL-ITWQSPLERAHIVKFYTI----KYRTDAQWKTLNRGQIRPEETQYLV 845

Human  1249 PNLSRNRQYSVWVVAVTSAGRGNSSEIITVEPLAKAPARILTFSGTV--TTPWMKDIVLPCKAVG 1311
            .||...|.|...|:|.:.....:|.|:....| |:...:.:| :|.|  ...::..|:|...||.
  Fly   846 KNLVGGRTYYFRVLANSEKSYESSDEVKFPVP-ARVKHKAIT-AGVVGGILFFIVAIILSVCAVK 908

Human  1312 --DPSPAVKWMKDSNGTPSLVTIDGRRSIFSNGSFIIRTVKAEDSGYYSCIANNNWGSDEI---- 1370
              :.....|..|:.|.....:| |.|....:|.....|:..:..||.   :....:....|    
  Fly   909 ICNKRKRRKQEKEFNMVACRIT-DARNIAANNHHLHNRSTGSISSGQ---VPLKKYKQTRISSLT 969

Human  1371 ---ILNLQVQVPPDQPRLTVSKTTSSSITLSWLPGDNGGSSIRGYI--LQYSEDNSEQWGSFPI- 1429
               |..|....|||  |.|...:..||..|.....|:||...|..:  :|.|.|     |.|.: 
  Fly   970 AILIAILHWIWPPD--RCTNCHSIYSSPNLEDGDEDDGGGGRRRSVSRIQRSLD-----GRFVLD 1027

Human  1430 --SPSERSYRLENLKCGTWYKFTLTAQNGVGPGRISEI-----------------IEAKTLGKEP 1475
              ..|:..|..:.|:.|.    ......|:...|.|.:                 |.|:...:.|
  Fly  1028 VEGVSKLGYSQQTLESGN----VDVVDGGLFERRNSNVSQKSSSDDGGFLSRRNFITARASWRRP 1088

Human  1476 QFSKEQELFASINTTRVR-----LNLIGWNDGGCPITS------------FTLEYRPF--GTTVW 1521
            ..:...:|.........|     |..||......|..|            :....||:  ...::
  Fly  1089 LVASSSQLSLQSAADSARGFLQGLLKIGAKQSAVPPNSQSYFDEAVSGARYQNVLRPYTSSNNLY 1153

Human  1522 TTAQRT----------SLSKSYILY--------------DLQEATWYELQMRVCNSAGCAEKQAN 1562
            ..|.|:          |||:...||              .||.    ..|..:.:|.|......:
  Fly  1154 GNADRSRPLHINTISGSLSQQQQLYTPSRISRIFSSSPQQLQP----HHQQLLLSSGGSGAYPTH 1214

Human  1563 FATLNYDGSTI-PPLIKSVVQNEEGLTT-----NEGLKMLVTISCILVGVLLLFVLLLVVRRRRR 1621
            |:.|    ||: ||  .|..::...|::     ::.|..|.||.              ...||::
  Fly  1215 FSDL----STVYPP--NSAERSSHNLSSRYRYYSQELPSLRTIQ--------------EETRRQQ 1259

Human  1622 EQRLKRLRDA------------KSLAEMLMSKNTRT-------SDTLSKQQQTLRMHIDIPRAQL 1667
            :|:...|.|.            :|..:...|...||       |...|.:||...|...:|  ||
  Fly  1260 QQKQHPLEDHFVPLQLPSPPSWRSYYQSQASYRPRTRWYPRHHSRLFSNRQQQHEMLSPLP--QL 1322

Human  1668 LIEERDTMETIDDRSTVLLTDADFGEAAKQKSLTVTHTVHYQSVSQATGPLVDVSDARPGTNPTT 1732
            .:..|::|                                                 .||     
  Fly  1323 NLNLRNSM-------------------------------------------------NPG----- 1333

Human  1733 RRNAKAGPTARNR---YASQWTLNRPHPTISAHTLTTDWR-LPTPRAAGSVDKESDSYSVSPSQD 1793
              ..:|.|.:|:.   :.|:.|.|.|..       |::|| ||..||..|..|.|..:....:|.
  Fly  1334 --GLEASPESRSSSSGFGSKNTSNHPGS-------TSEWRLLPPYRAPPSPPKHSGYFGGQQAQG 1389

Human  1794 TDRARSSMVSTESASSTYEELARAYEHAKMEEQLRHAKFTITECFISDTSSEQLTAGTNEYTDSL 1858
                     .|...|.:|.....             ..:|:....       ::.:..|..|||.
  Fly  1390 ---------QTPHGSYSYPRATT-------------PPYTMAHWL-------EMISRLNAATDSN 1425

Human  1859 TSSTP------SESGICRFTASPPKPQDGGRV---MNMAV---PKAHR-----PGDLIHL-PPYL 1905
            ....|      |..|...|..:.|.|.....:   :|:.:   |..|.     .|.|:|. .|| 
  Fly  1426 LPKAPCPVDVGSVDGHYEFDPATPTPSASSMLREDLNLHIDTHPYHHHTLGPLSGSLLHSHAPY- 1489

Human  1906 RMDFLLNRGGPGTSRDLSL 1924
                     |.|..:..||
  Fly  1490 ---------GGGARKQRSL 1499

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
DSCAMNP_001380.2 FN3 885..978 CDD:238020 13/110 (12%)
FN3 <937..1300 CDD:442628 81/376 (22%)
Ig_3 1287..1363 CDD:464046 17/79 (22%)
FN3 1380..1470 CDD:238020 25/111 (23%)
FN3 1486..1555 CDD:238020 19/111 (17%)
Required for netrin-mediated axon repulsion of neuronal growth cones. /evidence=ECO:0000250|UniProtKB:Q9ERC8 1617..2012 65/349 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1718..1810 22/95 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1855..1883 9/33 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1971..2012
Ig 26..121 CDD:472250
Ig strand B 42..46 CDD:409353
Ig strand C 55..59 CDD:409353
Ig strand E 79..83 CDD:409353
Ig strand F 99..104 CDD:409353
Ig strand G 112..116 CDD:409353
Ig 125..210 CDD:472250
Ig strand B 141..145 CDD:409353
Ig strand C 157..161 CDD:409353
Ig strand E 179..183 CDD:409353
Ig strand F 192..199 CDD:409353
I-set 235..310 CDD:400151
Ig strand B 242..246 CDD:409353
Ig strand C 255..259 CDD:409353
Ig strand F 290..295 CDD:409353
Ig 313..395 CDD:472250
Ig strand B 331..335 CDD:409353
Ig strand C 344..348 CDD:409353
Ig strand E 368..372 CDD:409353
Ig strand F 382..387 CDD:409353
Ig 406..501 CDD:472250 22/109 (20%)
Ig strand B 424..428 CDD:409353 1/3 (33%)
Ig strand C 437..441 CDD:409353 2/3 (67%)
Ig strand E 467..471 CDD:409353 2/8 (25%)
Ig strand F 481..486 CDD:409353 1/4 (25%)
Ig strand G 494..497 CDD:409353 0/2 (0%)
IgI_5_Dscam 504..593 CDD:409550 22/103 (21%)
Ig strand A 505..507 CDD:409550 0/1 (0%)
Ig strand A' 512..516 CDD:409550 0/9 (0%)
Ig strand B 519..526 CDD:409550 2/6 (33%)
Ig strand C 533..539 CDD:409550 0/5 (0%)
Ig strand C' 540..542 CDD:409550 0/6 (0%)
Ig strand D 549..553 CDD:409550 0/3 (0%)
Ig strand E 557..563 CDD:409550 2/5 (40%)
Ig strand F 571..579 CDD:409550 4/7 (57%)
Ig strand G 583..593 CDD:409550 1/9 (11%)
Ig 596..686 CDD:472250 31/91 (34%)
Ig strand B 613..617 CDD:409353 0/3 (0%)
Ig strand C 627..631 CDD:409353 1/3 (33%)
Ig strand E 652..656 CDD:409353 1/3 (33%)
Ig strand F 666..671 CDD:409353 3/4 (75%)
Ig strand G 679..682 CDD:409353 1/2 (50%)
Ig_DSCAM 689..784 CDD:409397 32/94 (34%)
putative Ig strand A 689..693 CDD:409397 0/3 (0%)
putative Ig strand A' 698..702 CDD:409397 1/3 (33%)
putative Ig strand B 704..714 CDD:409397 4/9 (44%)
putative Ig strand C 720..726 CDD:409397 1/5 (20%)
putative Ig strand C' 733..736 CDD:409397 0/2 (0%)
putative Ig strand D 744..747 CDD:409397 0/2 (0%)
putative Ig strand E 749..755 CDD:409397 4/5 (80%)
putative Ig strand F 762..770 CDD:409397 5/7 (71%)
putative Ig strand G 775..784 CDD:409397 4/8 (50%)
Ig_DSCAM 785..884 CDD:409398 22/103 (21%)
putative Ig strand A 785..788 CDD:409398 0/2 (0%)
putative Ig strand A' 796..800 CDD:409398 0/3 (0%)
putative Ig strand B 803..810 CDD:409398 0/6 (0%)
putative Ig strand C 818..824 CDD:409398 2/5 (40%)
putative Ig strand C' 833..836 CDD:409398 0/2 (0%)
putative Ig strand D 842..846 CDD:409398 0/3 (0%)
putative Ig strand E 848..854 CDD:409398 0/5 (0%)
putative Ig strand F 861..869 CDD:409398 2/7 (29%)
putative Ig strand G 872..882 CDD:409398 2/11 (18%)
tutlNP_001303307.1 V-set 138..250 CDD:462230 27/124 (22%)
I-set 253..341 CDD:400151 30/90 (33%)
Ig strand B 271..275 CDD:409353 0/3 (0%)
Ig strand C 284..288 CDD:409353 1/3 (33%)
Ig strand E 308..311 CDD:409353 1/2 (50%)
Ig strand F 321..326 CDD:409353 3/4 (75%)
Ig strand G 334..337 CDD:409353 1/2 (50%)
Ig 346..437 CDD:472250 32/92 (35%)
Ig strand B 362..366 CDD:409353 2/3 (67%)
Ig strand C 376..380 CDD:409353 1/3 (33%)
Ig strand E 402..406 CDD:409353 3/3 (100%)
Ig strand F 416..421 CDD:409353 3/4 (75%)
Ig strand G 430..433 CDD:409353 1/2 (50%)
Ig <459..530 CDD:472250 17/78 (22%)
Ig strand B 459..462 CDD:409353 0/2 (0%)
Ig strand C 471..476 CDD:409353 1/4 (25%)
Ig strand E 496..500 CDD:409353 0/3 (0%)
Ig strand F 510..515 CDD:409353 1/4 (25%)
Ig strand G 523..526 CDD:409353 0/2 (0%)
Ig_3 535..615 CDD:464046 11/96 (11%)
FN3 633..725 CDD:238020 25/105 (24%)
FN3 786..874 CDD:238020 24/92 (26%)
Blue background indicates that the domain is not in the aligned region.

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