DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment DSCAM and tutl

DIOPT Version :9

Sequence 1:NP_001380.2 Gene:DSCAM / 1826 HGNCID:3039 Length:2012 Species:Homo sapiens
Sequence 2:NP_001303307.1 Gene:tutl / 46015 FlyBaseID:FBgn0010473 Length:1536 Species:Drosophila melanogaster


Alignment Length:1709 Identity:365/1709 - (21%)
Similarity:585/1709 - (34%) Gaps:465/1709 - (27%)


- Green bases have known domain annotations that are detailed below.


Human   406 TPKIISAFSEKVV------SPAEPVSLMCNVK----GTPLPTITWTLDDDPILKGGSHRISQMIT 460
            :|...:||:.|..      ..||..|:...::    .||.|||               ::.|.: 
  Fly    66 SPAKTAAFTVKTTRRRRSRRRAEGSSICVPIRRGQGSTPTPTI---------------QVLQFV- 114

Human   461 SEGNVVSYL-----NISSSQVRDGGVYRCTANNSAGVVLYQARINVRGPASIRPMKNI------T 514
                :||.|     |..:..:.:..|: .||....||:.   ..:|..| :..|:..:      .
  Fly   115 ----LVSLLALLAKNAQAHNIPEDAVH-ITAILGEGVIF---NCHVEFP-NDHPVPYVLQWDKKV 170

Human   515 AIAGRDTYIHCRVIGYPYYSIKWYKN-----SNLLPFNHRQVAFENNGTLKLSDVQKEVDEGEYT 574
            :..|.|..|:.....||.:..:.||.     |...||        .:.:|.|::: :|.|:|.|.
  Fly   171 SETGSDLPIYIWYESYPEHIEEGYKGRVSRVSQDSPF--------GSASLNLTNI-RESDQGWYE 226

Human   575 CNVLV----QPQLSTSQSVHVTVKVPP--FIQPFEFPRFSIGQRVFIPCVVVSGDLPITITWQKD 633
            |.|:.    ..|.......|:.|..||  .:.|.:....::|..:.:.|.......| .|.|.||
  Fly   227 CKVVFLNRDPKQHKNGTWFHLDVHAPPRFSVTPEDIIYVNLGDSIILNCQADGTPTP-EILWYKD 290

Human   634 GRPIPGSLGVTIDNIDFTSSLRISNLSLMHNGNYTCIARNEAAAVEHQSQLIVRVPPKFVVQPRD 698
            ..|:..|..|.|.| |.| .||||.:.....|.|||||||....|.|.:::|:......:|.|.:
  Fly   291 ANPVDPSPTVGIFN-DGT-ELRISTIRHEDIGEYTCIARNGEGQVSHTARVIIAGGAVIMVPPTN 353

Human   699 QDGIYGKAVILNCSAEGYPVPTIVWKFSKGAGVPQFQPIALNGRIQVLSNGSLLIKHVVEEDSGY 763
            |..:.|:.||.:|.|:..|....|..:.:|:  |..:..||..|:.:..:|||:|..:..:|||.
  Fly   354 QTKLEGEKVIFSCEAKAMPGNVTVRWYREGS--PVREVAALETRVTIRKDGSLIINPIKPDDSGQ 416

Human   764 YLCKVSNDVGADVSKSMYLTVKIPAMITSYPNTTLATQGQKKEMSCTAHGEKPI-IVRWEKEDRI 827
            |||:|:|.:|...|.|.||:|:.||.:|..|............:.|.......: .|.|.|:.|:
  Fly   417 YLCEVTNGIGDPQSASAYLSVEYPAKVTFTPTVQYLPFRLAGVVQCYIKSSPQLQYVTWTKDKRL 481

Human   828 INPEMARYLVSTKEVGEEVISTLQILPT-VRED-SGFFSCHAINSYGE--DRGIIQLTVQEPP-- 886
            :.|...:.:|        |::...:|.| |.|: .|.::|...|:.|.  ..|::.:.|::||  
  Fly   482 LEPYQMKDIV--------VMANGSLLFTRVNEEHQGQYACTPYNAQGTAGASGVMDVLVRKPPAF 538

Human   887 -------------DPPEIEIKDVKARTI---TLRWTMGFDGNSPITGYDIECKNKSDSWDSAQRT 935
                         |..|:....::|...   |::|.                :.:.:....:||.
  Fly   539 TVEPETLYQRKVGDSVEMHCDALEAEGTERPTIKWQ----------------RQEGEQLTESQRN 587

Human   936 KDVSPQLNSATIIDIHPSSTYSIRMYAKNRIGKSEPSNELTITADEAAPDGPPQEVHLEPISSQS 1000
            : :.....:.||.::........:....|.:.......:|.|...:  |..|             
  Fly   588 R-IKISGGNITIENLRREDFGYYQCVVSNEVATLMAVTQLVIEGTQ--PHAP------------- 636

Human  1001 IRVTWKAPKKHLQNGIIRGYQIG--YRE-----YSTGGNFQFNIISVDTSGDSEVYTLDNLNKFT 1058
            ..:|.||.:..:....:.||..|  |::     :...|...:..|||..||.::| |::.|...|
  Fly   637 YNITGKATESSITLQWLPGYSGGSEYKQDYTIWFREAGVNDWQTISVTPSGSTQV-TINGLASGT 700

Human  1059 QYGLVVQACNRAGTGPSSQEIITTTLEDVPSYPPENVQAIATSPESISISWSTLSKEALNGILQG 1123
            .|...|...|..|.|..|:.:...||||.|: .|.||:|....|:|.   :..:..||   .|..
  Fly   701 TYEFQVVGRNVLGDGMMSKVMTVRTLEDAPA-APRNVKAATQPPDSF---FQLMPDEA---DLLA 758

Human  1124 FRVIYWANLMDGELGEIKNITTTQPSLELDGLEKYTNYSIQVLAFTRAGDGVRSEQIFTRTKEDV 1188
            :..||:.....|.|      ..:.|.|                                |.|...
  Fly   759 YFDIYFHTDSRGTL------VYSPPKL--------------------------------RVKGPK 785

Human  1189 PGPPAGVKAAAASASMVFVSWLPPLKLNGIIRKYTVFCSHPYPT-----VISEFEASPDSFSYRI 1248
            ||||..|.....|...: ::|..||:...|::.||:    .|.|     .::..:..|:...|.:
  Fly   786 PGPPRNVSVTEVSNGFL-ITWQSPLERAHIVKFYTI----KYRTDAQWKTLNRGQIRPEETQYLV 845

Human  1249 PNLSRNRQYSVWVVAVTSAGRGNSSEIITVEPLAKAPARILTFSGTV--TTPWMKDIVLPCKAVG 1311
            .||...|.|...|:|.:.....:|.|:....| |:...:.:| :|.|  ...::..|:|...||.
  Fly   846 KNLVGGRTYYFRVLANSEKSYESSDEVKFPVP-ARVKHKAIT-AGVVGGILFFIVAIILSVCAVK 908

Human  1312 --DPSPAVKWMKDSNGTPSLVTIDGRRSIFSNGSFIIRTVKAEDSGYYSCIANNNWGSDEI---- 1370
              :.....|..|:.|.....:| |.|....:|.....|:..:..||.   :....:....|    
  Fly   909 ICNKRKRRKQEKEFNMVACRIT-DARNIAANNHHLHNRSTGSISSGQ---VPLKKYKQTRISSLT 969

Human  1371 ---ILNLQVQVPPDQPRLTVSKTTSSSITLSWLPGDNGGSSIRGYI--LQYSEDNSEQWGSFPI- 1429
               |..|....|||  |.|...:..||..|.....|:||...|..:  :|.|.|     |.|.: 
  Fly   970 AILIAILHWIWPPD--RCTNCHSIYSSPNLEDGDEDDGGGGRRRSVSRIQRSLD-----GRFVLD 1027

Human  1430 --SPSERSYRLENLKCGTWYKFTLTAQNGVGPGRISEI-----------------IEAKTLGKEP 1475
              ..|:..|..:.|:.|.    ......|:...|.|.:                 |.|:...:.|
  Fly  1028 VEGVSKLGYSQQTLESGN----VDVVDGGLFERRNSNVSQKSSSDDGGFLSRRNFITARASWRRP 1088

Human  1476 QFSKEQELFASINTTRVR-----LNLIGWNDGGCPITS------------FTLEYRPF--GTTVW 1521
            ..:...:|.........|     |..||......|..|            :....||:  ...::
  Fly  1089 LVASSSQLSLQSAADSARGFLQGLLKIGAKQSAVPPNSQSYFDEAVSGARYQNVLRPYTSSNNLY 1153

Human  1522 TTAQRT----------SLSKSYILY--------------DLQEATWYELQMRVCNSAGCAEKQAN 1562
            ..|.|:          |||:...||              .||.    ..|..:.:|.|......:
  Fly  1154 GNADRSRPLHINTISGSLSQQQQLYTPSRISRIFSSSPQQLQP----HHQQLLLSSGGSGAYPTH 1214

Human  1563 FATLNYDGSTI-PPLIKSVVQNEEGLTT-----NEGLKMLVTISCILVGVLLLFVLLLVVRRRRR 1621
            |:.|    ||: ||  .|..::...|::     ::.|..|.||.              ...||::
  Fly  1215 FSDL----STVYPP--NSAERSSHNLSSRYRYYSQELPSLRTIQ--------------EETRRQQ 1259

Human  1622 EQRLKRLRDA------------KSLAEMLMSKNTRT-------SDTLSKQQQTLRMHIDIPRAQL 1667
            :|:...|.|.            :|..:...|...||       |...|.:||...|...:|  ||
  Fly  1260 QQKQHPLEDHFVPLQLPSPPSWRSYYQSQASYRPRTRWYPRHHSRLFSNRQQQHEMLSPLP--QL 1322

Human  1668 LIEERDTMETIDDRSTVLLTDADFGEAAKQKSLTVTHTVHYQSVSQATGPLVDVSDARPGTNPTT 1732
            .:..|::|                                                 .||     
  Fly  1323 NLNLRNSM-------------------------------------------------NPG----- 1333

Human  1733 RRNAKAGPTARNR---YASQWTLNRPHPTISAHTLTTDWR-LPTPRAAGSVDKESDSYSVSPSQD 1793
              ..:|.|.:|:.   :.|:.|.|.|..       |::|| ||..||..|..|.|..:....:|.
  Fly  1334 --GLEASPESRSSSSGFGSKNTSNHPGS-------TSEWRLLPPYRAPPSPPKHSGYFGGQQAQG 1389

Human  1794 TDRARSSMVSTESASSTYEELARAYEHAKMEEQLRHAKFTITECFISDTSSEQLTAGTNEYTDSL 1858
                     .|...|.:|.....             ..:|:....       ::.:..|..|||.
  Fly  1390 ---------QTPHGSYSYPRATT-------------PPYTMAHWL-------EMISRLNAATDSN 1425

Human  1859 TSSTP------SESGICRFTASPPKPQDGGRV---MNMAV---PKAHR-----PGDLIHL-PPYL 1905
            ....|      |..|...|..:.|.|.....:   :|:.:   |..|.     .|.|:|. .|| 
  Fly  1426 LPKAPCPVDVGSVDGHYEFDPATPTPSASSMLREDLNLHIDTHPYHHHTLGPLSGSLLHSHAPY- 1489

Human  1906 RMDFLLNRGGPGTSRDLSL 1924
                     |.|..:..||
  Fly  1490 ---------GGGARKQRSL 1499

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
DSCAMNP_001380.2 Ig 45..113 CDD:319273
I-set 235..310 CDD:254352
I-set 315..385 CDD:333254
Ig_3 407..488 CDD:316449 20/95 (21%)
IGc2 518..575 CDD:197706 16/61 (26%)
I-set 596..686 CDD:333254 31/91 (34%)
Ig_DSCAM 707..784 CDD:143211 28/76 (37%)
Ig 802..889 CDD:325142 21/106 (20%)
FN3 885..978 CDD:238020 13/110 (12%)
FN3 986..1083 CDD:238020 24/103 (23%)
FN3 1091..1184 CDD:238020 15/92 (16%)
FN3 1189..1278 CDD:238020 24/93 (26%)
Ig 1303..1369 CDD:319273 14/67 (21%)
FN3 1380..1470 CDD:238020 25/111 (23%)
FN3 1486..1555 CDD:238020 19/111 (17%)
Required for netrin-mediated axon repulsion of neuronal growth cones. /evidence=ECO:0000250|UniProtKB:Q9ERC8 1617..2012 65/349 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1718..1810 22/95 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1855..1883 9/33 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1971..2012
tutlNP_001303307.1 V-set 137..250 CDD:284989 27/126 (21%)
IG_like 137..229 CDD:214653 24/105 (23%)
I-set 253..341 CDD:254352 30/90 (33%)
IGc2 268..331 CDD:197706 26/65 (40%)
I-set 346..437 CDD:254352 32/92 (35%)
Ig 349..437 CDD:299845 32/89 (36%)
Ig 459..530 CDD:299845 17/78 (22%)
IG_like 549..628 CDD:214653 11/95 (12%)
IGc2 551..617 CDD:197706 10/82 (12%)
FN3 633..725 CDD:238020 25/105 (24%)
FN3 786..874 CDD:238020 24/92 (26%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3510
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR10075
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.910

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