DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment DSCAM and Dscam3

DIOPT Version :10

Sequence 1:NP_001380.2 Gene:DSCAM / 1826 HGNCID:3039 Length:2012 Species:Homo sapiens
Sequence 2:NP_996226.2 Gene:Dscam3 / 42103 FlyBaseID:FBgn0261046 Length:2087 Species:Drosophila melanogaster


Alignment Length:2070 Identity:632/2070 - (30%)
Similarity:960/2070 - (46%) Gaps:235/2070 - (11%)


- Green bases have known domain annotations that are detailed below.


Human    34 VVFASTTGTLVPCPAAGIPPVTLRWYLATGEEIYDVPGIRHVHPNGTLQIFPFPPSSFSTLIHDN 98
            ::|.:.||..|.|.|.|.||..:.|.|..|.....|||:|.:..||||...||....:.|.:|:.
  Fly    48 LLFGNDTGAQVTCTAHGSPPPLVTWVLRDGSLATQVPGLRKISGNGTLHFPPFLAQYYRTDVHEA 112

Human    99 TYYCTAENPSGKIRSQDVHIKAVLREPYTVRVEDQKTMRGNVAVFKCIIPSSVEAYITVVSWEK- 162
            ||.|.|.|.:|.:.|::|.:.||:|..:.|.||:.:...||.|:.||.||..|..|:.|.||.: 
  Fly   113 TYRCRASNEAGTVLSRNVQVHAV
VRRQFHVHVENTEVYLGNSALIKCAIPEYVRPYVRVASWHRG 177

Human   163 -----DTVSLVSGSRFLITSTGALYIKDVQNEDGLYNYRCITRHRYTGETRQSNSARLFVSD--- 219
                 ..:|.|:|...::.::|.||::.|::||||..:.|:..:...||.::|::..|.|.:   
  Fly   178 EEILLPDLSDVAGRYVVLAASGDLYVRSVRSEDGLMKFSCLVTNTLNGERQRSDAVMLQVKELSK 242

Human   220 ---PANSAPSILDGFDHRKAMAGQRVELPCKALGHPEPDYRWLKDN-----MPLELSGRFQKTVT 276
               |..:...:::....|    |..|.|||...|:|.|.:.|.:.:     .|:..|.|...:.|
  Fly   243 NLAPRTTQKPVMEIHVER----GNDVHLPCNIQGNPFPIFTWYRVSDSAALYPIPSSQRVILSRT 303

Human   277 GLLIENIRPSDSGSYVCEVSNRYGTAKVIGRLYVKQPLKATISPRKVKSSVGSQVSLSCSVTGTE 341
            .|||:|....|:|.::|:.||::|..::..||.|...:...|.|:....:.|...:.:|:.||:.
  Fly   304 LLLIKNADERDAGKWICQASNQFGEQRIEIRLSVNSYVSVHILPQVQIVNSGGTANFNCTTTGSA 368

Human   342 DQELSWYRNGEILNPGKNVRITG------INHENLIMDHMVKSDGGAYQCFVRKDKLSAQDYVQV 400
            ...:.|..||:.|. ..|...||      ::..:|::.::.:.|.|.|||.|...:.|||...::
  Fly   369 IDAIDWLHNGKPLQ-ANNALTTGRDNIRFLSKSSLLVQNVGRRDRGVYQCLVENQRASAQAMAEL 432

Human   401 VLEDGTPKIISAFSEKVVSPAEPVSLMCNVKGTPLPTITWTLDDDPILKGGSHR---ISQMITSE 462
            .|.|..|::|..|.|:.|.|...:||.|:..|:|.|...|.||..||:....|.   |.|.:...
  Fly   433 KLGDTVPELIYTFIEQNVRPGPLISLKCSASGSPPPQFAWLLDSQPIMDVSLHHRFAIGQFVDMS 497

Human   463 GNVVSYLNISSSQVRDGGVYRCTANNSAGVVLYQARINVRGPASIRPMKNITAIAGRDTYIHCRV 527
            |:|:|:||||..:..|||:|:|.|:||.|.|.:.||:||.||..:|.:..|.|:||.|..:||..
  Fly   498 GDVISHLNISHVRPDDGGLYKCVASNSMGSVQHSARLNVYGPPYVRAIGPIKAVAGEDIIVHCPF 562

Human   528 IGYPYYSIKWYK-NSNLLPFNHRQVA-FENNGTLKLSDVQKEVDEGEYTCNVLVQPQLSTSQSVH 590
            .|||...|:|.| :..|...||.::| ..:.|.|.:.:|:...|:|.|||.|..:......:.:.
  Fly   563 AGYPVEQIRWEKAHQELTTSNHYELASVADGGQLVIKNVEPGRDQGIYTCIVRSRAGEEARRDMQ 627

Human   591 VTVKVPPFIQPFEFPR-FSIGQRVFIPCVVVSGDLPITITWQKDGRPIPGSLGVTIDNIDFTSSL 654
            :.|..||.|:||:||: ...|.|..|.|.|.|||:||..:|:||...||.||.:|....:|.|.|
  Fly   628 LNVNSPPVIEPFKFPKNLQEGGRAQITCAVSSGDMPIYFSWKKDDSSIPSSLQITEKKEEFYSLL 692

Human   655 RISNLSLMHNGNYTCIARNEAAAVEHQSQLIVRVPPKFVVQPRDQDGIYGKAVILNCSAEGYPVP 719
            ...::|..|:|.|||.|.|.||.|.:.::|.|||.|::..:|.|...:.|..:.:||.|||||:|
  Fly   693 VFKDISARHSGKYTCYASNAAAKVNYTAELQVRVAPRWRYEPMDTAIMLGNTISINCEAEGYPIP 757

Human   720 TIVWKFSKGAGVPQFQPIALNGRIQVLSNGSLLIKHVVEEDSGYYLCKVSNDVGADVSKSMYLTV 784
            ||.|...:|.|...|:|:::.       |.|||:....:.|.|||:|:.:|::||.:.|::.:.|
  Fly   758 TITWFKGQGKGSKDFKPLSMR-------NHSLLLNLATDNDEGYYMCQATNEIGAGLKKTIRINV 815

Human   785 KIPAMITSYPNTTLATQGQKKEMSCTAHGEKPIIVRWEKEDRIINPEMARYLVSTKEVGEEVIST 849
            ..||..........:.:.....:.|.|.|::||.:.|.:.:..|:....|:.::..:..:.|.|.
  Fly   816 NEPARFEQSARNISSRRNDPVTLDCHAKGDEPITIGWTQNNGRIDLNNFRFSIAEMKTEKGVDSQ 880

Human   850 LQILPTVREDSGFFSCHAINSYGEDRGIIQLTVQEPPD-PPEIEIKDVKARTITLRWTMGFDGNS 913
            |.|..:.|.|||.:.|.|.|.||....||.|.|||.|| |..:||.:|.:||:.|.|...|||||
  Fly   881 LTIGHSDRHDSGVYRCIAENPYGRAEQIIFLAVQERPDTPSHLEIFEVGSRTVKLSWRRPFDGNS 945

Human   914 PITGYDIECK-----------------------NKSDSWDSAQRTKDVSPQLNSATIIDIHPSST 955
            |:..|.::.:                       |.|....|..|:.| |....||.:..:.|::|
  Fly   946 PVLSYLVQYQALKYLQSHGSLAAAGGDWNGHVINVSLPSTSISRSYD-SDLRESAIVAGLTPATT 1009

Human   956 YSIRMYAKNRIGKSEPSNELTITADEAAPDGPPQEVHLEPISSQSIRVTWKAPKKHLQNGIIRGY 1020
            :.|||.|.|.|.:|..:..:.:...|.||...|..|.::......:.|||:.|.:...||.:.||
  Fly  1010 FLIRMQAINEIERSAYTEAIVLKTQEEAPTEAPSNVQVQTGGESELIVTWQIPPRESWNGELIGY 1074

Human  1021 QIGYREYSTGGNFQFNIISVDTSGDSEVY--------TLDNLNKFTQYGLVVQACNRAGTGPSSQ 1077
            .:...|.....||   |..|::|..|.:.        ||..|.|:::|.:.::|.|..|:||.|.
  Fly  1075 TVNCSEEKQNINF---ISVVNSSLKSTIVSGWATTKATLRGLRKYSRYAVTIRAMNSFGSGPWSA 1136

Human  1078 EIITTTLEDVPSYPPENVQAIATSPESISISWSTLSKEALNGILQGFRVIYW---------ANLM 1133
            .|..||.|.||...|:||...|.|.:|:.|||.....:...||:||::::|.         |.| 
  Fly  1137 AIFGTTAEGVPEAAPQNVNCTALSSQSLKISWLEPPLQFHGGIIQGYKILYRPIVHQIDFPAKL- 1200

Human  1134 DGELGEIKNITTTQPSLELDGLEKYTNYSIQVLAFTRAGDGVRSEQIFTRTKEDVPGPPAGVKAA 1198
                 |||.  |:.....|..|.|.:||||:|||:|..|||:.|..:|.:|.:|||..||.:|||
  Fly  1201 -----EIKR--TSNLETYLHTLHKASNYSIRVLAYTATGDGLASHPLFCQTDDDVPDAPAAIKAA 1258

Human  1199 AASASMVFVSWLPPLKLNGIIRKYTVFC----------SHPYPTVISEFEASPDSFSYRIPNLSR 1253
            |.:|..:.:|||.|...||||..|||:.          :|   .|..:....|.:|..|  :|:.
  Fly  1259 ALTADSILISWLTPKNRNGIISHYTVYSREAGRKGQAKTH---MVRVDENGYPVTFESR--SLAE 1318

Human  1254 NRQYSVWVVAVTSAGRGNSSEIITVEPLAKAPARILTFSGTVTTPWMKDIVLPCKAVGDPSPAVK 1318
            |:.|..||.|.||.|.|..:.:|......:|||||.:|...|.......:||.|.|||:|:|..:
  Fly  1319 NQMYEFWVSASTSVGEGEPTSVIAQATNTRAPARIASFGQVVRKAVGTGLVLECLAVGNPTPRAR 1383

Human  1319 WMKDSNGTPSLVTIDGRRSIFSNGSFIIRTVKAEDSGYYSCIANNNWGSDEIILNLQVQVPPDQP 1383
            |:  :...|  ||......:.:.|:..|..|:...||.|:|.|||.:|||||...:....||..|
  Fly  1384 WL--TRDRP--VTFSPFYEVTNEGNLKIHRVEGSLSGNYTCTANNLFGSDEIQYQVIAMKPPSAP 1444

Human  1384 RLTVSKTTSSSITLSWLPGDNGGSSIRGYILQYSEDNSEQWGSFPISPSERSYRLENLKCGTWYK 1448
            ::.|...::.||.:||...|:||:.::||.:.| ....|.|....:.|...::.:..||||..|.
  Fly  1445 QIIVQYASADSIRVSWDAPDDGGAPLQGYTISY-HTAGESWSITELLPENNAFTISGLKCGNQYI 1508

Human  1449 FTLTAQNGVGPGRISEIIEAKTLGKEPQFSKEQELFASINTTRVRLNLIGWNDGGCPITSFTLEY 1513
            ..::|.|.||.|..||.|...|.||..|.....||.|: |.|.|.|.|..|.:|||.|..|::|:
  Fly  1509 IKMSAHNMVGSGVASEEINVWTKGKASQAPNANELIAT-NATCVNLKLSSWQNGGCSIHHFSIEH 1572

Human  1514 RPFGTTVWTTAQRTSLS------KSYILYDLQEATWYELQMRVCNSAGCAEKQANFATLNYDGST 1572
            ||.|...||.. .:.:|      ::.|..|...|.||:|::...|.||...:..:|:|.|.||.|
  Fly  1573 RPLGDIRWTVV-TSDISNAEENRENLIFCDFLPAKWYQLRISATNDAGKTTEHYHFSTTNIDGIT 1636

Human  1573 IPPLIKSVVQNEEGL----------TTNEGLKMLVTISCILVGVLLLFVLLLVVRRRRREQRLKR 1627
            |||  .||..:|..|          |:.:....|:.:..|.|.::   .:.|.::.||..     
  Fly  1637 IPP--PSVFPSENDLMNNLINSTNPTSGDWFATLIVVVIITVSII---TIALTIKHRRTL----- 1691

Human  1628 LRDAKSLAEMLMSKNTRTSDTLSKQQQTLRMHIDIPRAQLLIEERDTMETIDDRSTVLLTDADFG 1692
               ...:||   ...:||.....|:....|.:..:..|       ..::|:|.           |
  Fly  1692 ---CGPIAE---GYESRTLPGDYKEDHENRRNQQVYSA-------SPVKTVDK-----------G 1732

Human  1693 EAAKQKSLTVTHTVHYQSVSQATGPLVDVSDARPGTNPTTRRNAKAGPTARNRYASQW-TLNRPH 1756
            ..::.          |:....||   ..|:..|.|....|...|.|..|..: |..|: |...|.
  Fly  1733 NESEM----------YEISPYAT---FSVNGGRTGAPAKTPTRAVAAQTPLD-YTMQFKTFGHPE 1783

Human  1757 PTISAHTLTTDWRLPTPRAAGSVDKESDSYSVSPSQDTDRARSSMVSTESASSTYEELARAYEHA 1821
               ..:...|.:.|......|.|..:|..:........|.      ||.|.|.|....::| .|:
  Fly  1784 ---GENLNATAYPLLPSSGFGHVKSKSSWHKQRYYNTEDE------STLSKSMTIVAGSQA-GHS 1838

Human  1822 KMEEQLRHAKFTITECFISDTSSEQLTAGTNEYTDSLTSSTPSESGICRFTASPPKPQDGGRVMN 1886
            |.....|.||        |..:...:.||:...|....|:..|.....|......:..||..|::
  Fly  1839 KKSNGGRSAK--------SSAACSGVVAGSESDTSISPSTEFSNMPTYRVPCKSSRSSDGRAVVD 1895

Human  1887 MAVPKAHRPG---------DLIHLPP--YLRMDFLLNRGGPGTSRDLSLGQACLEPQKSRTLKRP 1940
            |..|.:....         :..|..|  .|.|...:..|| |....:..|..             
  Fly  1896 MFRPDSSTESNNDQGSPAPERRHNTPRHVLGMGMAMGLGG-GGGGGVGGGNG------------- 1946

Human  1941 TVLEPIPMEAASSASSTREGQSWQPGAVATLPQREGAELGQAAKMSSSQESLLDS 1995
                  |.|..|:...:|     :.|:.|..|..:..|..:....|:|.:|.:|:
  Fly  1947 ------PAEKRSAGQRSR-----KHGSAAQQPSNQTLERRKCPGSSNSLDSEVDA 1990

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
DSCAMNP_001380.2 FN3 885..978 CDD:238020 34/116 (29%)
FN3 <937..1300 CDD:442628 131/389 (34%)
Ig_3 1287..1363 CDD:464046 24/75 (32%)
FN3 1380..1470 CDD:238020 29/89 (33%)
FN3 1486..1555 CDD:238020 25/74 (34%)
Required for netrin-mediated axon repulsion of neuronal growth cones. /evidence=ECO:0000250|UniProtKB:Q9ERC8 1617..2012 75/391 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1718..1810 21/92 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1855..1883 6/27 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1971..2012 6/25 (24%)
Ig 26..121 CDD:472250 32/86 (37%)
Ig strand B 42..46 CDD:409353 1/3 (33%)
Ig strand C 55..59 CDD:409353 0/3 (0%)
Ig strand E 79..83 CDD:409353 3/3 (100%)
Ig strand F 99..104 CDD:409353 3/4 (75%)
Ig strand G 112..116 CDD:409353 1/3 (33%)
Ig 125..210 CDD:472250 29/90 (32%)
Ig strand B 141..145 CDD:409353 1/3 (33%)
Ig strand C 157..161 CDD:409353 2/3 (67%)
Ig strand E 179..183 CDD:409353 2/3 (67%)
Ig strand F 192..199 CDD:409353 2/6 (33%)
I-set 235..310 CDD:400151 25/79 (32%)
Ig strand B 242..246 CDD:409353 2/3 (67%)
Ig strand C 255..259 CDD:409353 0/3 (0%)
Ig strand F 290..295 CDD:409353 1/4 (25%)
Ig 313..395 CDD:472250 21/87 (24%)
Ig strand B 331..335 CDD:409353 0/3 (0%)
Ig strand C 344..348 CDD:409353 0/3 (0%)
Ig strand E 368..372 CDD:409353 1/3 (33%)
Ig strand F 382..387 CDD:409353 3/4 (75%)
Ig 406..501 CDD:472250 39/97 (40%)
Ig strand B 424..428 CDD:409353 2/3 (67%)
Ig strand C 437..441 CDD:409353 0/3 (0%)
Ig strand E 467..471 CDD:409353 2/3 (67%)
Ig strand F 481..486 CDD:409353 2/4 (50%)
Ig strand G 494..497 CDD:409353 0/2 (0%)
IgI_5_Dscam 504..593 CDD:409550 28/90 (31%)
Ig strand A 505..507 CDD:409550 0/1 (0%)
Ig strand A' 512..516 CDD:409550 1/3 (33%)
Ig strand B 519..526 CDD:409550 2/6 (33%)
Ig strand C 533..539 CDD:409550 2/5 (40%)
Ig strand C' 540..542 CDD:409550 0/1 (0%)
Ig strand D 549..553 CDD:409550 1/4 (25%)
Ig strand E 557..563 CDD:409550 2/5 (40%)
Ig strand F 571..579 CDD:409550 5/7 (71%)
Ig strand G 583..593 CDD:409550 0/9 (0%)
Ig 596..686 CDD:472250 40/90 (44%)
Ig strand B 613..617 CDD:409353 1/3 (33%)
Ig strand C 627..631 CDD:409353 0/3 (0%)
Ig strand E 652..656 CDD:409353 2/3 (67%)
Ig strand F 666..671 CDD:409353 3/4 (75%)
Ig strand G 679..682 CDD:409353 0/2 (0%)
Ig_DSCAM 689..784 CDD:409397 32/94 (34%)
putative Ig strand A 689..693 CDD:409397 1/3 (33%)
putative Ig strand A' 698..702 CDD:409397 1/3 (33%)
putative Ig strand B 704..714 CDD:409397 3/9 (33%)
putative Ig strand C 720..726 CDD:409397 3/5 (60%)
putative Ig strand C' 733..736 CDD:409397 1/2 (50%)
putative Ig strand D 744..747 CDD:409397 0/2 (0%)
putative Ig strand E 749..755 CDD:409397 3/5 (60%)
putative Ig strand F 762..770 CDD:409397 4/7 (57%)
putative Ig strand G 775..784 CDD:409397 1/8 (13%)
Ig_DSCAM 785..884 CDD:409398 27/98 (28%)
putative Ig strand A 785..788 CDD:409398 0/2 (0%)
putative Ig strand A' 796..800 CDD:409398 0/3 (0%)
putative Ig strand B 803..810 CDD:409398 0/6 (0%)
putative Ig strand C 818..824 CDD:409398 1/5 (20%)
putative Ig strand C' 833..836 CDD:409398 1/2 (50%)
putative Ig strand D 842..846 CDD:409398 0/3 (0%)
putative Ig strand E 848..854 CDD:409398 3/5 (60%)
putative Ig strand F 861..869 CDD:409398 3/7 (43%)
putative Ig strand G 872..882 CDD:409398 4/9 (44%)
Dscam3NP_996226.2 Ig 38..135 CDD:472250 32/86 (37%)
Ig strand B 56..60 CDD:409353 1/3 (33%)
Ig strand C 69..73 CDD:409353 0/3 (0%)
Ig strand E 93..97 CDD:409353 3/3 (100%)
Ig strand F 113..118 CDD:409353 3/4 (75%)
Ig strand G 126..130 CDD:409353 1/3 (33%)
Ig 246..337 CDD:472250 27/94 (29%)
Ig strand B 264..268 CDD:409353 2/3 (67%)
Ig strand C 277..281 CDD:409353 0/3 (0%)
Ig strand E 303..307 CDD:409353 2/3 (67%)
Ig strand F 317..322 CDD:409353 1/4 (25%)
Ig strand G 330..333 CDD:409353 0/2 (0%)
Ig 341..434 CDD:472250 23/93 (25%)
Ig strand B 358..362 CDD:409353 0/3 (0%)
Ig strand C 371..375 CDD:409353 0/3 (0%)
Ig strand E 400..404 CDD:409353 1/3 (33%)
Ig strand F 414..419 CDD:409353 3/4 (75%)
Ig strand G 427..430 CDD:409353 1/2 (50%)
IgI_4_Dscam 439..536 CDD:409548 39/96 (41%)
Ig strand A' 447..451 CDD:409548 1/3 (33%)
Ig strand B 454..463 CDD:409548 3/8 (38%)
Ig strand C 468..474 CDD:409548 2/5 (40%)
Ig strand C' 476..479 CDD:409548 0/2 (0%)
Ig strand D 487..495 CDD:409548 2/7 (29%)
Ig strand E 499..508 CDD:409548 5/8 (63%)
Ig strand F 515..523 CDD:409548 4/7 (57%)
Ig strand G 526..536 CDD:409548 4/9 (44%)
Ig 539..630 CDD:472250 28/90 (31%)
Ig strand B 556..560 CDD:409353 0/3 (0%)
Ig strand C 569..573 CDD:409353 1/3 (33%)
Ig strand E 594..598 CDD:409353 2/3 (67%)
Ig strand F 609..614 CDD:409353 3/4 (75%)
Ig strand G 623..626 CDD:409353 0/2 (0%)
Ig 633..724 CDD:472250 40/90 (44%)
Ig strand B 651..655 CDD:409353 1/3 (33%)
Ig strand C 665..669 CDD:409353 0/3 (0%)
Ig strand E 690..694 CDD:409353 2/3 (67%)
Ig strand F 704..709 CDD:409353 3/4 (75%)
Ig strand G 717..720 CDD:409353 0/2 (0%)
Ig 728..815 CDD:472250 32/93 (34%)
Ig strand B 745..749 CDD:409353 0/3 (0%)
Ig strand C 758..762 CDD:409353 2/3 (67%)
Ig strand E 780..784 CDD:409353 2/3 (67%)
Ig strand F 794..799 CDD:409353 3/4 (75%)
Ig strand G 808..811 CDD:409353 1/2 (50%)
Ig 820..913 CDD:472250 24/92 (26%)
Ig strand C 849..853 CDD:409353 0/3 (0%)
Ig strand E 879..883 CDD:409353 2/3 (67%)
Ig strand F 893..898 CDD:409353 1/4 (25%)
Ig strand G 906..909 CDD:409353 0/2 (0%)
FN3 <940..1417 CDD:442628 158/497 (32%)
Ig 1355..1430 CDD:472250 26/78 (33%)
Ig strand B 1368..1372 CDD:409353 2/3 (67%)
Ig strand C 1381..1385 CDD:409353 0/3 (0%)
Ig strand E 1403..1407 CDD:409353 1/3 (33%)
Ig strand F 1417..1422 CDD:409353 2/4 (50%)
Ig strand G 1430..1433 CDD:409353 2/2 (100%)
FN3 1441..1530 CDD:238020 29/89 (33%)
FN3 1542..1620 CDD:238020 29/79 (37%)

Return to query results.
Submit another query.