DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DSCAM and Ama

DIOPT Version :9

Sequence 1:	NP_001380.2	Gene:	DSCAM / 1826	HGNCID:	3039	Length:	2012	Species:	Homo sapiens
Sequence 2:	NP_731114.2	Gene:	Ama / 40831	FlyBaseID:	FBgn0000071	Length:	341	Species:	Drosophila melanogaster

Alignment Length:	340	Identity:	87/340 - (25%)
Similarity:	139/340 - (40%)	Gaps:	75/340 - (22%)

- Green bases have known domain annotations that are detailed below.

Human   313 PLKATISPRKVKSSVGSQVSLSCSVTGTEDQELSWYR-------NGEILN-------PGK--NVR 361
            |:.:.|| :.|.:|||..|..:|:|.......:||.:       |..:|:       |.:  ||.
  Fly    33 PVISQIS-KDVVASVGDSVEFNCTVEEVGQLSVSWAKRPSESDTNSVVLSMRNILSLPDQRYNVT 96

Human   362 IT-GINHENLIMDHMVK----SDGGAYQCFVR-------KDKLSAQDYVQVVLEDGTPKIISAFS 414
            :| |....:.|....::    ||.|.|:|.|.       ..|||.|.....|:.:.|||
  Fly    97 VTEGPKTGSAIYTFRIQNIEVSDMGPYECQVLVSATEKVTKKLSLQIKTPPVIAENTPK------ 155

Human   415 EKVVSPAEPVSLMCNVKGTPLPTITWTLDDDPILKGGSHRISQMITSEGNVVSYLNISSSQVRDG 479
            ..:|:..:.:.|.|:..|.|.|||:|..:.:.::..|.|.:::         ..|.|.|....|.
  Fly   156 STLVTEGQNLELTCHANGFPKPTISWAREHNAVMPAGGHLLAE---------PTLRIRSVHRMDR 211

Human   480 GVYRCTANNSAG---------VVLYQARINVRGPASIRPMKNITAIAGRDTYIHCRVIGYPYYSI 535
            |.|.|.|.|..|         .|.::.:|.|:.|       .|..:......:.|.|.|||..::
  Fly   212 GGYYCIAQNGEGQPDKRLIRVEVEFRPQIAVQRP-------KIAQMVSHSAELECSVQGYPAPTV 269

Human   536 KWYKNS-NLLPFNHRQVA--FENNGT----LKLSDVQKEVDEGEYTCNVLVQPQLSTSQSVHVTV 593
            .|:||. .|....|.:||  ..::||    |::..|.:| |.|:|.||       :|::..|...
  Fly   270 VWHKNGVPLQSSRHHEVANTASSSGTTTSVLRIDSVGEE-DFGDYYCN-------ATNKLGHADA 326

Human   594 KVPPFIQPFEFPRFS 608
            ::..|......|..|
  Fly   327 RLHLFQTVIPVPSLS 341

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DSCAM	NP_001380.2	Ig	45..113	CDD:319273
		I-set	235..310	CDD:254352
		I-set	315..385	CDD:333254	23/90 (26%)
		Ig_3	407..488	CDD:316449	21/80 (26%)
		IGc2	518..575	CDD:197706	20/63 (32%)
		I-set	596..686	CDD:333254	3/13 (23%)
		Ig_DSCAM	707..784	CDD:143211
		Ig	802..889	CDD:325142
		FN3	885..978	CDD:238020
		FN3	986..1083	CDD:238020
		FN3	1091..1184	CDD:238020
		FN3	1189..1278	CDD:238020
		Ig	1303..1369	CDD:319273
		FN3	1380..1470	CDD:238020
		FN3	1486..1555	CDD:238020
		Required for netrin-mediated axon repulsion of neuronal growth cones. /evidence=ECO:0000250\|UniProtKB:Q9ERC8	1617..2012
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1718..1810
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1855..1883
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1971..2012
Ama	NP_731114.2	I-set	33..143	CDD:254352	29/110 (26%)
		Ig	37..127	CDD:299845	24/90 (27%)
		IG_like	154..234	CDD:214653	23/94 (24%)
		IGc2	161..223	CDD:197706	19/70 (27%)
		I-set	254..330	CDD:254352	24/83 (29%)
		IGc2	254..322	CDD:197706	23/75 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810