DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DSCAM and dpr16

DIOPT Version :9

Sequence 1:	NP_001380.2	Gene:	DSCAM / 1826	HGNCID:	3039	Length:	2012	Species:	Homo sapiens
Sequence 2:	NP_001287169.1	Gene:	dpr16 / 40619	FlyBaseID:	FBgn0037295	Length:	488	Species:	Drosophila melanogaster

Alignment Length:	309	Identity:	76/309 - (24%)
Similarity:	107/309 - (34%)	Gaps:	96/309 - (31%)

- Green bases have known domain annotations that are detailed below.

Human    73 RHVHPNGTLQIFPFPPSSFSTLIHDNTYY-CTAENPSGK----IRSQDVHIKAVLREPYTVRVED 132
            |.:.|...|.:   ||.:.:.....:.|. |.....|||    :|.:|.||.||   .:|..:.|
  Fly   193 RELLPRRQLSL---PPLNATVQAGQHAYLPCKLNQHSGKPLSWVRLRDEHIIAV---DHTTFIND 251

Human   133 QKTMRGNVAVFKCIIPSSVEAYITVVSWEKDTVSLVSGSRFLITST------------------- 178
                    |.|..::.|:.            ..:||||.....|:|
  Fly   252 --------ARFASLLQSTT------------LTTLVSGGALSTTATPVAALGNSFAHAVPGGQER 296

Human   179 -------GALYIKDVQNEDGLYNYRCITRHRYTGETRQSNSARLFVSDPANSAPSILDGFDHRKA 236
                   ..|.||.|..||..: |.|    :...|.:.|...:|||..|...    |.|...|..
  Fly   297 GNSSSLSWTLQIKYVNLEDAGW-YEC----QLATEPKMSAKVQLFVITPRTE----LIGDRQRFV 352

Human   237 MAGQRVELPCKALGHPE-PDY-RWLKDNMPL----ELSG------------------RFQKTVTG 277
            .||.||||.|...|..| |.| .|.:.:..:    |.||                  ..:.|:..
  Fly   353 KAGSRVELHCIVRGTLEAPKYIFWYRGDQQVTAENEASGAQSGWYTQIDRNIFGSTEHNRNTIGS 417

Human   278 LLIENIRPSDSGSYVCEVSNRYGTAKVIGRLYVKQPLKATISPRKVKSS 326
            |:|..:|...||:|.||..|   :|....:|:|   |....|...:||:
  Fly   418 LVIPLVRKIHSGNYTCEPEN---SAAASMQLHV---LSGEYSASAIKST 460

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DSCAM	NP_001380.2	Ig	45..113	CDD:319273	10/44 (23%)
		I-set	235..310	CDD:254352	27/98 (28%)
		I-set	315..385	CDD:333254	3/12 (25%)
		Ig_3	407..488	CDD:316449
		IGc2	518..575	CDD:197706
		I-set	596..686	CDD:333254
		Ig_DSCAM	707..784	CDD:143211
		Ig	802..889	CDD:325142
		FN3	885..978	CDD:238020
		FN3	986..1083	CDD:238020
		FN3	1091..1184	CDD:238020
		FN3	1189..1278	CDD:238020
		Ig	1303..1369	CDD:319273
		FN3	1380..1470	CDD:238020
		FN3	1486..1555	CDD:238020
		Required for netrin-mediated axon repulsion of neuronal growth cones. /evidence=ECO:0000250\|UniProtKB:Q9ERC8	1617..2012
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1718..1810
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1855..1883
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1971..2012
dpr16	NP_001287169.1	IG_like	205..337	CDD:214653	34/159 (21%)
		Ig	<298..338	CDD:299845	12/44 (27%)
		IG_like	352..447	CDD:214653	27/97 (28%)
		Ig	358..439	CDD:143165	22/83 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810