DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DSCAM and Cont

DIOPT Version :9

Sequence 1:	NP_001380.2	Gene:	DSCAM / 1826	HGNCID:	3039	Length:	2012	Species:	Homo sapiens
Sequence 2:	NP_649461.2	Gene:	Cont / 40553	FlyBaseID:	FBgn0037240	Length:	1390	Species:	Drosophila melanogaster

Alignment Length:	1332	Identity:	277/1332 - (20%)
Similarity:	455/1332 - (34%)	Gaps:	379/1332 - (28%)

- Green bases have known domain annotations that are detailed below.

Human    95 IHDNTYYCTAENPSGKIRSQDVHIKAVLREPYTVRVEDQKTMRGNVAVFKCIIPSSVEAYITVVS 159
            :|||.:....:..:..|.:.:....::   |.||...:|..:||.:...:   |.....|:
  Fly   241 LHDNRFLVQNDLNNQNINNPNQFYNSL---PGTVNQRNQNNLRGFIGPNQ---PYGDNRYV---- 295

Human   160 WEKDTVSLVSGSR---------------FLITSTGALYIKDVQN----EDGLYNY-------RCI 198
              :|.|......:               ..|..:..||..|..|    :...|:|       ..|
  Fly   296 --RDRVVYAFSKKRDRWMFMPAYEIELNLFICESKVLYSSDNVNIKLDDKRPYHYGLDINDMERI 358

Human   199 TRHRYTGETRQSNSARLFVSDPANSAPSILDGFDHRKAMAGQRVELPCKALGHPEPDYRWLKD-- 261
            .|..|            ||..|.::.      ||..|......|.|.|.|.|:|.|.|.|.::
  Fly   359 PRGPY------------FVKQPNDTT------FDVNKNRLINDVTLSCLANGYPTPSYTWYREVY 405

Human   262 -NMPLELSGRFQK---------TVTG---LLIENIRPSDSGSYVCEVSNRYGTAKVIGRLYVKQP 313
             :..||    :||         |::|   ::.|..:..|.|:|.|...|::|
  Fly   406 VDDRLE----YQKIDPLAQDRYTISGGNLIIYEPKQALDQGAYHCVAENKFG------------- 453

Human   314 LKATISPRKVKSSVGSQVSLSCSVTGTEDQELSWYRNGEILNPGKNVRITGINH----------- 367
               .|.......:.|..:..:.. ...|..|::|         ||::......|
  Fly   454 ---RIRSESAHLNFGFIMEFNLK-RSAETSEMNW---------GKSIFCDPPQHYPDVRYYWARD 505

Human   368 --ENLIMDH---MVKSDGGAYQCFVRK-DKLSAQDYVQVVLEDG-----------TPK-----II 410
              .|.:.:.   .|..||..|..|:.. |:.:....||.::.|.           ||.     :|
  Fly   506 YFPNFVEEDQRVFVSRDGALYFSFIETVDRANYSCTVQTLVSDTGRNGPFFPLRVTPNSNYQALI 570

Human   411 SAFSEKVVSPAEPVS-----LMCNVKGTPLPTITWTLDDDPILKGGSHRISQMITSEGNVVSYLN 470
            .|.:...|.|..||:     |.|...|.|:|:..||....| |:..::.|:.     |.|   |.
  Fly   571 FANTFPKVFPEAPVAGDEIRLECMAFGYPIPSYNWTRQGLP-LQRNAYTINY-----GRV---LI 626

Human   471 ISSSQVRDGGVYRCTANNSAGVVLYQARINVR-GPASIRPMKNITAIAGRDTYIHCRVIGYPYYS 534
            |.::...|.|.|.||..|....::....||:: .|....|:|::......|....|.....|..:
  Fly   627 IQNATTNDNGEYSCTITNPRKTLMKSIYINIQMRPQFTIPLKDMIKDYNSDVTFICEAFAIPDAN 691

Human   535 IKWYKNSNLL-PFN---HRQVAFENNGTLKLSDVQKEVDEGEYTCNVLVQPQLSTSQSVHVTVKV 595
            ..||||:..| |.|   .|.:..:|..|:|.  ::|:.|:..|.|.  .|.||.||
  Fly   692 YTWYKNAERLDPANINRDRYIIQDNVLTIKF--LEKDKDDAMYQCG--AQNQLKTS--------- 743

Human   596 PPFIQPFEFPRFSIGQRVFIPCVVVSGDLPITITWQKDGRPIPGSLGVTIDNIDFTSSLRISNLS 660
                       ||..|                                          ||:.::.
  Fly   744 -----------FSSAQ------------------------------------------LRVLSMK 755

Human   661 LMHNGNYTCIARNEAAAVEHQSQLIVRVPPKFVVQPRDQD--GIYGKAVILNCSAEGYPVPTIVW 723
                                         |.|...|.:.:  .:|.....:.|..|..|.|...|
  Fly   756 -----------------------------PSFKKHPLESEVYAVYNGNTTIVCDPEAAPRPKFQW 791

Human   724 KFSKGAGVPQFQPIALNGRIQVLSNGSLLIKHVVEEDSGYYLCKVSNDVGADVSKSMYLTVKIPA 788
            |       ...|.|...|..::|.:|:|.|.....:|.|.|.|..||..|.|.|.:..:.::...
  Fly   792 K-------KDGQVIGSGGHRRILPSGTLTISPTSRDDEGIYTCIASNQAGTDESHARVIVLQEIR 849

Human   789 MITSYPNTTLATQGQKKEMSCTAHGEK--PIIVRWEKEDRII---NPEMARYLVSTKEVGEEVIS 848
            .|.:.|...::.:.....:.|.|..::  .|...|:....::   :....|.:|..        :
  Fly   850 FIETPPQRIVSKEHDLIFLHCEAAFDELLDIAYVWKHNGEVLKNNHDGTGRIIVDW--------N 906

Human   849 TLQILPTVREDSGFFSCHAINSYGEDRGIIQLTVQEPPDPP----EIEIKDVKARTITLRWTMGF 909
            .|.:..|...|:|.:.|...::..|......::::..|..|    .|:|...||   .:.|..|.
  Fly   907 RLTVHNTSMRDAGDYECVVKSAVNEISSKTSVSIEGAPGAPGGVQVIQISKTKA---IIEWVDGS 968

Human   910 DGNSPITGYDIECK-NKSDSWDSAQ-----RTKDVSPQLNSATIIDIHPSSTYSIRMYAKNRIGK 968
            .....|..|:|..: |.:.:|.:..     |..|.......|.::::.|.|.|...:.|.|.:|.
  Fly   969 HNGRAIRYYNILGRTNWNRTWVNVSTHVQAREVDRYTSRQQAEVVNLTPWSAYEFSVTAVNDLGI 1033

Human   969 SEPS---------------------------NELTITADEAAPDGPPQEVHLEPISSQSIRVTWK 1006
            ..||                           .:||||.|...    |||.|...|   ..:|.||
  Fly  1034 GTPSAPSPIYSTYEDKPYIAPRNVGGGGGKIGDLTITWDPLL----PQEQHSHGI---HYKVFWK 1091

Human  1007 APKKHLQNGIIRGYQIGYREYSTGGNFQFNIISVDTSGDSEVYTLDNL----------NKFTQYG 1061
                      ::|                   :::.:.| |:...|::          |.:|:|.
  Fly  1092 ----------LKG-------------------AIEWASD-EIKKQDHMGVAVVNIPLNNYYTEYE 1126

Human  1062 LVVQACNRAGTGPSSQEIITTTLEDVPSYPPENVQAIATSPESISISWS--TLSKEALNGILQGF 1124
            :.|||.|..|.||.|:..:..:.||:|...|:...|:|.:....:::|.  .:|:|.:.|.|.|.
  Fly  1127 VKVQAINSVGKGPESEIAVIHSAEDMPQVAPQKPIALAYNSTCFNVTWQPIDMSRENIRGKLIGH 1191

Human  1125 RVIYWANLMDGELGEIKNITTTQPSLELDGLEKYTNYSIQVLAFTRAGDGVRSEQIFTRTKEDVP 1189
            |:.||......|........||:....:.||:..|.|.::|:|:..||:|..||:...||....|
  Fly  1192 RLKYWKTTHQEEDSVYYLSRTTRNWALIVGLQPDTYYFVKVMAYNAAGEGPESERFEERTYRKAP 1256

Human  1190 -GPPAGVKAAAASASMVFVSW--LPPLKLNGIIRKYTV----------FCSHPYPTVISEFEASP 1241
             .||:.|.....:.|.|.|.|  :.|.:....:..|.|          ..::....:..:.|
  Fly  1257 QKPPSSVHVYGINPSTVRVVWRYVSPSQDEEPVEGYKVRIWESDQNMITANNTIVPIGQKLE--- 1318

Human  1242 DSFSYRIPNLSRNRQYSVWVVAVTSAGRGNSS 1273
               || |.||:..:.|::.|:|.::.|.|..|
  Fly  1319 ---SY-INNLTPGKSYNMRVLAYSNGGDGRMS 1346

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DSCAM	NP_001380.2	Ig	45..113	CDD:319273	4/17 (24%)
		I-set	235..310	CDD:254352	23/89 (26%)
		I-set	315..385	CDD:333254	13/85 (15%)
		Ig_3	407..488	CDD:316449	26/90 (29%)
		IGc2	518..575	CDD:197706	17/60 (28%)
		I-set	596..686	CDD:333254	5/89 (6%)
		Ig_DSCAM	707..784	CDD:143211	22/76 (29%)
		Ig	802..889	CDD:325142	13/91 (14%)
		FN3	885..978	CDD:238020	26/129 (20%)
		FN3	986..1083	CDD:238020	23/106 (22%)
		FN3	1091..1184	CDD:238020	26/94 (28%)
		FN3	1189..1278	CDD:238020	23/98 (23%)
		Ig	1303..1369	CDD:319273
		FN3	1380..1470	CDD:238020
		FN3	1486..1555	CDD:238020
		Required for netrin-mediated axon repulsion of neuronal growth cones. /evidence=ECO:0000250\|UniProtKB:Q9ERC8	1617..2012
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1718..1810
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1855..1883
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1971..2012
Cont	NP_649461.2	CLECT	139..>223	CDD:214480
		Ig	361..460	CDD:299845	30/136 (22%)
		I-set	362..462	CDD:254352	30/137 (22%)
		Ig	466..559	CDD:299845	16/102 (16%)
		IG_like	584..657	CDD:214653	22/81 (27%)
		IGc2	586..645	CDD:197706	19/67 (28%)
		Ig	667..751	CDD:299845	28/149 (19%)
		IG_like	676..751	CDD:214653	27/140 (19%)
		IG_like	765..844	CDD:214653	23/85 (27%)
		Ig	773..844	CDD:299845	22/77 (29%)
		I-set	851..940	CDD:254352	14/96 (15%)
		Ig	866..944	CDD:299845	12/85 (14%)
		FN3	944..1043	CDD:238020	24/101 (24%)
		FN3	1053..1146	CDD:238020	28/129 (22%)
		fn3	1156..1244	CDD:278470	24/87 (28%)
		fn3	1259..1346	CDD:278470	21/93 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10075
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010