DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DSCAM and dpr10

DIOPT Version :9

Sequence 1:	NP_001380.2	Gene:	DSCAM / 1826	HGNCID:	3039	Length:	2012	Species:	Homo sapiens
Sequence 2:	NP_729591.1	Gene:	dpr10 / 39180	FlyBaseID:	FBgn0052057	Length:	408	Species:	Drosophila melanogaster

Alignment Length:	237	Identity:	49/237 - (20%)
Similarity:	88/237 - (37%)	Gaps:	73/237 - (30%)

- Green bases have known domain annotations that are detailed below.

Human   511 KNITAIAGRDTYIHCRVIGYPYYSIKWYKNSNLLPFN----------------HRQVAFENNGTL 559
            :|||::.|:..|:.|||......::.|.::.:|....                ||.:   :..||
  Fly    61 RNITSLVGKSAYLGCRVKHLGNKTVAWIRHRDLHILTVGTYTYTTDQRFQTSYHRDI---DEWTL 122

Human   560 KLSDVQKEVDEGEYTCNVLVQPQLSTSQSVHVT----VKVPPFIQPF------------------ 602
            ::...|:. |.|.|.|.:..||..|.|.::::.    .:....:|.:
  Fly   123 QIKWAQQR-DAGVYECQISTQPVRSYSVNLNIVDLIDAETSDIMQQYYNDDAFYIAENRVYQSSN 186

Human   603 -EF------------PRFSI----------GQRVFIPCVV-VSGDLPITITWQKDGRPIP----- 638
             ||            |..:|          |..:.:.|:: .|.:.|..|.|....:.:.
  Fly   187 DEFAGMFGPIQTVAVPTATILGGPDLYVDKGSTINLTCIIKFSPEPPTHIFWYHQDKVLSEETSG 251

Human   639 GSLGV-TIDNIDFTSSLRISNLSLMHNGNYTCIARN-EAAAV 678
            |.|.. ||.:.:..|.|.|.:..|:|:|.|:|...| |.|::
  Fly   252 GRLKFKTIKSEETKSILLIYDADLLHSGKYSCYPSNTEIASI 293

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DSCAM	NP_001380.2	Ig	45..113	CDD:319273
		I-set	235..310	CDD:254352
		I-set	315..385	CDD:333254
		Ig_3	407..488	CDD:316449
		IGc2	518..575	CDD:197706	15/72 (21%)
		I-set	596..686	CDD:333254	26/132 (20%)
		Ig_DSCAM	707..784	CDD:143211
		Ig	802..889	CDD:325142
		FN3	885..978	CDD:238020
		FN3	986..1083	CDD:238020
		FN3	1091..1184	CDD:238020
		FN3	1189..1278	CDD:238020
		Ig	1303..1369	CDD:319273
		FN3	1380..1470	CDD:238020
		FN3	1486..1555	CDD:238020
		Required for netrin-mediated axon repulsion of neuronal growth cones. /evidence=ECO:0000250\|UniProtKB:Q9ERC8	1617..2012
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1718..1810
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1855..1883
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1971..2012
dpr10	NP_729591.1	Ig	63..143	CDD:299845	18/83 (22%)
		IG_like	210..297	CDD:214653	21/84 (25%)
		IGc2	217..287	CDD:197706	18/69 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810