DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment DSCAM and Dscam2

DIOPT Version :9

Sequence 1:NP_001380.2 Gene:DSCAM / 1826 HGNCID:3039 Length:2012 Species:Homo sapiens
Sequence 2:NP_001261500.1 Gene:Dscam2 / 38788 FlyBaseID:FBgn0265296 Length:2101 Species:Drosophila melanogaster


Alignment Length:1991 Identity:631/1991 - (31%)
Similarity:982/1991 - (49%) Gaps:169/1991 - (8%)


- Green bases have known domain annotations that are detailed below.


Human     1 MWI----LALSLFQSFANVFSEDLHSSLY---FVNASLQEVVFASTTGTLVPCPAAGIPPVTLRW 58
            |||    ..:.|..:..|..||...:.|.   ||......|.|::::|..:.|.|:|.|..|:.|
  Fly     1 MWISSRFFVILLLLNLDNTCSEPFEAHLRGPGFVMEPPGRVEFSNSSGGWLDCSASGSPQPTVDW 65

Human    59 YLATGEEIYDVPGIRHVHPNGTLQIFPFPPSSFSTLIHDNTYYCTAENPSGKIRSQDVHIKAVLR 123
            ..|.|..:.::.|:|.|..||||.:.||..:::...:|:..|.|.|.|..|:|.|:||.::||:.
  Fly    66 VHADGSAVTEIHGVRRVLRNGTLVLMPFAAAAYHQDVHNTIYRCIASNSVGRIVSRDVQVRAVVA 130

Human   124 EPYTVRVEDQKTMRGNVAVFKCIIPSSVEAYITVVSWEKDTV-----SLVSGSRFLITSTGALYI 183
            :.|.|.||.....||..|:.:|::|:.|:..:.||||..:..     ||....:|.:..||.|.|
  Fly   131 QAYKVDVEVLSAARGCTAILRCVVPTFVKELVRVVSWVHEPAIYIYPSLQGDGKFHLLPTGELLI 195

Human   184 KDVQNEDGLYNYRCITRHRYTGETRQSNSARLFVSDPANS-----APSILDGFDHRKAMAGQRVE 243
            .::|..|...::||.:.||.|.:...|:..||.:    ||     :||:::...|.:....:...
  Fly   196 HNLQESDESQSFRCRSMHRLTRQVVVSSPTRLRI----NSHRGIISPSVVEHTAHVQVSQDEGAV 256

Human   244 LPCKALGHPEPDYRWLKDN----MPLELSG-RFQKTVTGLLIENIRPSDSGSYVCEVSNRYGTAK 303
            |.|.|.|.|.|:|.|...|    :|: ||| |.:.....|.||.:...|||.|.|...|..|.|.
  Fly   257 LLCVAQGCPSPEYSWFTHNGAGPLPV-LSGPRVRLLGPILAIEAVTGEDSGVYKCTAGNVGGEAS 320

Human   304 VIGRLYVKQPLKATISPRKVKSSVGSQVSLSCSVTGTED----QELSWYRNGEILNPGKNVRITG 364
            ...||.|..|::..|||..:...:|......|.||....    |.:.||::      |:.:..:|
  Fly   321 AELRLTVATPIQVEISPNVLSVHMGGTAEFRCLVTSNGSPVGMQNILWYKD------GRQLPSSG 379

Human   365 INHENLIMDHMVKSDGGAYQCFVRK---DKLSAQDYVQVVLEDGTPKIISAFSEKVVSPAEPVSL 426
            ...:.|::..:.:.:.|.|||.||:   |...|...:|  |.|..|.::.:|.|:.:.|...|||
  Fly   380 RVEDTLVVPRVSRENRGMYQCVVRRPEGDTFQATAELQ--LGDAPPVLLYSFIEQTLQPGPAVSL 442

Human   427 MCNVKGTPLPTITWTLDDDPILKGGSHRISQMITSEGNVVSYLNISSSQVRDGGVYRCTANNSAG 491
            .|:..|.|.|.|:||||..|:...|...|.|.||..|:|:|::|||...|.|||.|.|.|.|.||
  Fly   443 KCSAAGNPTPQISWTLDGFPLPSNGRFMIGQYITVHGDVISHVNISHVMVEDGGEYACIAENRAG 507

Human   492 VVLYQARINVRGPASIRPMKNITAIAGRDTYIHCRVIGYPYYSIKWYKNSNLLPFNHRQVAFENN 556
            .|.:.||:|:.|...||.:..:||::|....:.|.|.|||...|.|.:....||.:.|| ..:.:
  Fly   508 RVQHAARLNIYGLPYIRLIPKVTAVSGETLNLKCPVAGYPIEEIHWERGGRELPDDIRQ-RVQPD 571

Human   557 GTLKLSDVQKEVDEGEYTCNVLVQPQLSTSQSVHVTVKVPPFIQPFE--FPRFSIGQRVFIPCVV 619
            |:|.:|.|||..|.|.|||....:...|..:|..|||.|||.:.||:  ..:.::|.|..:.|.|
  Fly   572 GSLTISPVQKNSDSGVYTCWARNKQGHSARRSGEVTVIVPPKLSPFQTNILQLNMGDRASLTCSV 636

Human   620 VSGDLPITITWQKDGRPIPGSLGVTIDNID-FTSSLRISNLSLMHNGNYTCIARNEAAAVEHQSQ 683
            |.||||:||.|:||||||..:..:::..:| :.|.|.|.||...|.|||:|:.||.||.||:...
  Fly   637 VKGDLPLTINWRKDGRPIDPTQHMSVKQVDQYNSILVIENLGSDHTGNYSCVVRNSAAEVENSQA 701

Human   684 LIVRVPPKFVVQPRDQDGIYGKAVILNCSAEGYPVPTIVWKFSKGAGVPQFQPIALNGRIQVLSN 748
            |:|.|||:::|:|.|.:....:.::|:|.|:|.|.|:||||.:.|:...:::.:......::|.|
  Fly   702 LLVNVPPRWIVEPVDANVERNRHIMLHCQAQGVPTPSIVWKKATGSKSGEYEEVRERPFTKLLGN 766

Human   749 GSLLIKHVVEEDSGYYLCKVSNDVGADVSKSMYLTVKIPAMITSYPNTTLATQGQKKEMSCTAHG 813
            ||||::||.|:..|:|||:.:|.:|..:.|.:.|.|......:|...:.:..:|....:.|...|
  Fly   767 GSLLLQHVKEDREGFYLCQANNGIGTGIGKVIQLKVNSSPYFSSTSRSVMVKKGDTALLQCAVSG 831

Human   814 EKPIIVRWEKEDR-IINPEMARYLVSTKE--VGEEVISTLQILPTVREDSGFFSCHAINSYGEDR 875
            :|||.:.|.:..: .:||. ..|.:|.|:  ..:.|.:.|||......|||.:.|.|.|.||.|:
  Fly   832 DKPINIVWMRSGKNTLNPS-TNYKISVKQEATPDGVSAELQIRTVDATDSGPYFCRASNLYGNDQ 895

Human   876 GIIQLTVQEPPDPPEI-EIKDVKARTITLRWTMGFDGNSPITGYDIECKNKS---------DSWD 930
            .::||.|||||.||.: |...:.:|::.::|.....|...:|.|.:|.:...         |.|.
  Fly   896 QLVQLQVQEPPLPPSVLEAAMISSRSVNIKWQPKTLGTGDVTKYIVEFREADHSLPPALFVDQWQ 960

Human   931 SAQRTKDVSPQLNSATIIDIHPSSTYSIRMYAKNRIGKSEPSNELTITADEAAPDGPPQEVHLEP 995
            ..: .|| .|..| |.|.::.|::.|:.|:.|:...|:|.||.||.:..:...|.|||..:...|
  Fly   961 QIE-VKD-PPHFN-AMIENLKPATRYAFRVIAEGSAGRSAPSQELIVRTEPQRPAGPPLSLSARP 1022

Human   996 ISSQSIRVTWKAPKKHLQNGIIRGYQIGYREYSTGGNFQFNIISVDTSGD--SEVYTLDNLNKFT 1058
            :||..:.::|.||...|::|.|:||.:||: .|:.||..:|..||...||  :....|..|.||.
  Fly  1023 LSSTELLISWVAPLPELRHGDIQGYNVGYK-LSSSGNTAYNFTSVSGDGDGGNGELLLSGLAKFA 1086

Human  1059 QYGLVVQACNRAGTGPSSQEIITTTLEDVPSYPPENVQAIATSPESISISWSTLSKEALNGILQG 1123
            :|.:||||.|:.|.||.|:.....|:|||||.|||:|:..|.|.:|:.:||........||:|||
  Fly  1087 RYTVVVQAFNQVGPGPLSEPTAAQTMEDVPSRPPEDVRCAALSSQSLQVSWQPPPIYHTNGLLQG 1151

Human  1124 FRVIYWANLMD--GELGEIKNITTTQPSLELDGLEKYTNYSIQVLAFTRAGDGVRSEQIFTRTKE 1186
            :::|:...:.|  ....|:::..||..::.|.||.|||||||||||.||.||||.|:.:|..::|
  Fly  1152 YKLIFEPIIDDIQPSKDEVESRKTTALTMVLTGLRKYTNYSIQVLAHTRMGDGVVSKPLFCHSEE 1216

Human  1187 DVPGPPAGVKAAAASASMVFVSWLPPLKLNGIIRKYTVFCSHPYPTVI-------SEFEASPDSF 1244
            |||..||.:|..::|:..:::|||||.:.||:|.||::     |..|:       :|..:.|...
  Fly  1217 DVPEAPADIKVVSSSSQSLYISWLPPNEPNGVITKYSL-----YTRVVNGREELNNEKRSLPSQQ 1276

Human  1245 S-YRIPNLSRNRQYSVWVVAVTSAGRGNSSEIITVEPLAKAPARILTFSGTVTTPWMKDIVLPCK 1308
            : |....|..:.:|..||.|.|..|.|.||.:.:.....:.||||::|.|.|..||...:.|||.
  Fly  1277 AYYEAKGLHPHMEYQFWVTASTRVGEGKSSRVSSQITTNRIPARIISFGGPVVRPWRSTVTLPCT 1341

Human  1309 AVGDPSPAVKWMKD-----SNGTPSLVTIDGRRSIFSNGSFIIRTVKAEDSGYYSCIANNNWGSD 1368
            |||.|..  :|.|.     ..|..:...:|       :|..||.:::..|.|.|||..:|..|:|
  Fly  1342 AVGKPKR--EWFKSDVALRQGGLHNSQLLD-------SGDLIISSLQLADGGNYSCQVDNGIGTD 1397

Human  1369 EIILNLQVQVPPDQPRLTVSKTTSSSITLSWLPGDNGGSSIRGYILQYSEDNSEQWGSFPISPSE 1433
            .:...|.|||||..|.|.|:..|||||.:.|..|..|.:.|.||.|.|...|... ....:|...
  Fly  1398 RLTHTLIVQVPPTAPVLYVTSATSSSILMHWKCGFTGNAPITGYTLFYRRANGNT-DEMQLSRHA 1461

Human  1434 RSYRLENLKCGTWYKFTLTAQNGVGPGRISEIIEAKTLGKEPQFSKEQELFASINTTRVRLNLIG 1498
            .|:.|:.|.||:.|:..|:|||.||....|.|:..:|.|:.|.......|.|. |:|.:.:.|..
  Fly  1462 SSHELKGLMCGSTYQIHLSAQNKVGTSPTSTILHVRTQGQSPGHPASTALLAP-NSTSLLVRLHS 1525

Human  1499 WNDGGCPITSFTLEYRPF---GTTVWT-TAQRTSLSKSYILYDLQEATWYELQMRVCNSAGCAEK 1559
            |.|.|||:..|.|:||..   ....|. .:......:..::.:||.:|.|:|:|...|.||.::.
  Fly  1526 WPDNGCPLLYFVLQYRAVTDDPDAEWVLVSNALKPQRRIVINNLQPSTLYQLRMEAHNVAGISQA 1590

Human  1560 QANFATLNYDGSTIPPLIKSVVQNEEGLTT--NEGLKMLVTISCILVGVLLLFVLLLVVRRRRRE 1622
            :.||.||..||...||.|  :.:...|.||  ...:.:|:.....:.|:....::::|..|.   
  Fly  1591 EFNFVTLTKDGDPPPPEI--MHRGRSGQTTVIFANINLLIPTIAAVSGMFCTIIMIIVCYRH--- 1650

Human  1623 QRLKRLRDAKSLAEM-LMSKNTRTSDTLSKQQQTLRMHIDIPRAQLLIEER--DTMETIDDRSTV 1684
                .|::|..|||. .:.|.:..:...|:..|..|.:..|.:..:...::  :|.|.|...:|.
  Fly  1651 ----MLKNAPPLAEQSQIQKESLENRANSEAAQRERYYATIHKVSMQNNDKIPETSEDISPYATF 1711

Human  1685 LLTDADFGEAAKQ----KSLTVTHTVHYQSVSQATGPLVDVSDARPGTNPTTRRNA-KAGPTARN 1744
            .|::|. |..::.    .:.|:.|:..|...:.|.|    .|...|..:...||:: |..|.:..
  Fly  1712 QLSEAG-GNMSQPHHGGPANTLLHSFMYHERALAEG----CSSPPPAASKNRRRHSRKTEPESEE 1771

Human  1745 RYASQWTLNRPHPTISAHTLTTDWRLPTPRAAGSVDKESDSYSVSPSQDTDRARSSMVSTESASS 1809
            ..:.|                              |:.:.|.:.|.:|...:.:.|::...:.||
  Fly  1772 SESDQ------------------------------DQLTSSRTESSNQHEGKIKHSIIYHGAQSS 1806

Human  1810 TYEELARAYEHAKM---------EEQLRHAKFTITECFISDTSSEQLTAGTNEYTDSLTSSTPSE 1865
            |..:|:...|...:         .:|.:.:..|......|:..:...|:.||. |.:.|::|||.
  Fly  1807 TSSDLSPMSEQKSLPRRGRSRYHHQQYQFSTNTTPRHHNSNKMNNNTTSNTNT-TATNTTATPST 1870

Human  1866 SGICRFTASPPKPQDGGRVMNMAVPKAHRPGDLIHLPPYLR 1906
            |.......||    .||.:.:::.....:.....|:|..::
  Fly  1871 SSNSNKILSP----RGGNLKSISSTFKSQDSIQCHIPTLVK 1907

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
DSCAMNP_001380.2 Ig 45..113 CDD:319273 24/67 (36%)
I-set 235..310 CDD:254352 27/79 (34%)
I-set 315..385 CDD:333254 15/73 (21%)
Ig_3 407..488 CDD:316449 35/80 (44%)
IGc2 518..575 CDD:197706 21/56 (38%)
I-set 596..686 CDD:333254 40/92 (43%)
Ig_DSCAM 707..784 CDD:143211 28/76 (37%)
Ig 802..889 CDD:325142 32/89 (36%)
FN3 885..978 CDD:238020 29/102 (28%)
FN3 986..1083 CDD:238020 38/98 (39%)
FN3 1091..1184 CDD:238020 41/94 (44%)
FN3 1189..1278 CDD:238020 30/96 (31%)
Ig 1303..1369 CDD:319273 21/70 (30%)
FN3 1380..1470 CDD:238020 33/89 (37%)
FN3 1486..1555 CDD:238020 20/72 (28%)
Required for netrin-mediated axon repulsion of neuronal growth cones. /evidence=ECO:0000250|UniProtKB:Q9ERC8 1617..2012 58/307 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1718..1810 13/92 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1855..1883 9/27 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1971..2012
Dscam2NP_001261500.1 Ig 51..127 CDD:299845 27/75 (36%)
Ig 138..>203 CDD:299845 19/64 (30%)
I-set 238..327 CDD:254352 30/89 (34%)
Ig 247..327 CDD:299845 27/80 (34%)
I-set 332..418 CDD:254352 22/93 (24%)
IGc2 344..407 CDD:197706 16/68 (24%)
IG_like 432..517 CDD:214653 38/84 (45%)
IGc2 436..507 CDD:197706 33/70 (47%)
I-set 521..610 CDD:254352 32/89 (36%)
IGc2 533..597 CDD:197706 23/64 (36%)
Ig 630..699 CDD:143165 33/68 (49%)
IG_like 714..802 CDD:214653 30/87 (34%)
Ig 725..802 CDD:299845 28/76 (37%)
Ig 823..894 CDD:143165 23/71 (32%)
FN3 906..1006 CDD:238020 28/102 (27%)
FN3 1013..1111 CDD:238020 38/98 (39%)
FN3 1119..1209 CDD:238020 40/89 (45%)
FN3 1219..1313 CDD:238020 30/98 (31%)
Ig 1336..1402 CDD:143165 22/74 (30%)
FN3 1409..1498 CDD:238020 33/89 (37%)
FN3 1515..1588 CDD:238020 22/72 (31%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 137 1.000 Domainoid score I4888
eggNOG 1 0.900 - - E1_KOG3510
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 968 1.000 Inparanoid score I322
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG47134
OrthoDB 1 1.010 - - D10185at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - mtm8541
orthoMCL 1 0.900 - - OOG6_101656
Panther 1 1.100 - - O PTHR10075
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X1391
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1211.840

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