DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment DSCAM and wrapper

DIOPT Version :9

Sequence 1:NP_001380.2 Gene:DSCAM / 1826 HGNCID:3039 Length:2012 Species:Homo sapiens
Sequence 2:NP_477404.1 Gene:wrapper / 37555 FlyBaseID:FBgn0025878 Length:500 Species:Drosophila melanogaster


Alignment Length:544 Identity:115/544 - (21%)
Similarity:201/544 - (36%) Gaps:112/544 - (20%)


- Green bases have known domain annotations that are detailed below.


Human   559 LKLSDVQKEVDEGEYTCNVLVQPQLSTSQSVHVTVKVPPFIQPFEFPRFSIGQRVFIPCVVVSGD 623
            |.|..||.|:|         ....|..||...   .:|..::.:|      ...|.:||.:   :
  Fly    16 LILGQVQAELD---------FNNDLENSQKFK---SIPTTVKTYE------NDTVQLPCTL---N 59

Human   624 LPIT-ITWQKDGRPIPGSLGVTI---DNIDF--TSSLRISNLSLMHNGNYTCIARNEAAAVEHQS 682
            .|.. :.|.:|...:..|....:   |.|..  ..||:::|:.....|:|.|...:::..|..|.
  Fly    60 TPFRYVRWHRDDVALVDSRHPELPPPDRIMLWPNGSLQVANVQSSDTGDYYCEMNSDSGHVVQQH 124

Human   683 QLIVRVPPKFVVQPRD-QDGIYGKAVILNCSAEGYPVPTIVWKFSKGAGVPQFQPIALNGR-IQV 745
            .:.|::.|:.:::|.| .:...|....:.|.|:|.|.|.|.|:              |||. ||.
  Fly   125 AIEVQLAPQVLIEPSDLTEQRIGAIFEVVCEAQGVPQPVITWR--------------LNGNVIQP 175

Human   746 LSN----GSLLIKHVVEEDSGYYLCKVSNDVGADVSKSMYLTVKIPAMITSYPNTTLATQ-GQKK 805
            .||    .||:::......:|...|..||.||.....::||.|.....: |.|...:.|: |.:.
  Fly   176 QSNTGNRQSLILEIKSRNQAGLIECVASNGVGEPAVANVYLHVLFSPEV-SIPQPVVYTKLGSRA 239

Human   806 EMSCTAHGEKPIIVRW---------------EKEDRIINPEMARYLVSTKEVGEEVISTLQILPT 855
            .:.|.........|:|               .:.:...|..:..|:        ..:..:.::.:
  Fly   240 HLECIVEAAPAATVKWFHHGLPVALGAHSTTHESELQTNRSVDHYV--------NAVRHMLVVKS 296

Human   856 VRE-DSGFFSCHAINSYGEDRGIIQLTVQEPPDPPEIEIKDVKARTITLRWTMGFDGNSPITGYD 919
            ||. |.|.:.|.|.|......|.::||.:..|...:|......:.:..|.|..  :...||..:.
  Fly   297 VRNADMGQYECRASNQISVKSGSVELTGRPMPCLFKINPGTQSSTSHVLVWQT--ESLLPIMEFK 359

Human   920 IE---------CKNKSDSWDS----AQRTKDVSPQLNSATIIDIHPSSTYSIRMYAKNRIGKSEP 971
            ::         .:....:|..    ||.|..:. .:.:.|:..:.|:|.|.:.:.|:|..|.|:.
  Fly   360 LKFRQIPSNNVTRQVRTNWTELTIPAQATNGLI-YITTYTLHGLQPASLYEVSVLARNSFGWSDN 423

Human   972 SNELTITADEAAPDGPPQEVHLEPISSQSIRVTWKAPKKHLQNGIIR---GYQIGYREYSTGGNF 1033
            |..:..     |..|   ||.|...|::|          .||:....   ..:|..|......:.
  Fly   424 SKIVRF-----ATGG---EVELPNYSTES----------ELQDDFTEEDFHNEITQRSEVLSASM 470

Human  1034 QFNIISVDTSG--DSEVYTLDNLN 1055
            .||..||:..|  .:.:|:|..:|
  Fly   471 MFNSGSVNGRGGISAFIYSLCLIN 494

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
DSCAMNP_001380.2 Ig 45..113 CDD:319273
I-set 235..310 CDD:254352
I-set 315..385 CDD:333254
Ig_3 407..488 CDD:316449
IGc2 518..575 CDD:197706 6/15 (40%)
I-set 596..686 CDD:333254 19/95 (20%)
Ig_DSCAM 707..784 CDD:143211 24/81 (30%)
Ig 802..889 CDD:325142 17/102 (17%)
FN3 885..978 CDD:238020 19/105 (18%)
FN3 986..1083 CDD:238020 18/75 (24%)
FN3 1091..1184 CDD:238020
FN3 1189..1278 CDD:238020
Ig 1303..1369 CDD:319273
FN3 1380..1470 CDD:238020
FN3 1486..1555 CDD:238020
Required for netrin-mediated axon repulsion of neuronal growth cones. /evidence=ECO:0000250|UniProtKB:Q9ERC8 1617..2012
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1718..1810
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1855..1883
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1971..2012
wrapperNP_477404.1 Ig 41..124 CDD:299845 18/91 (20%)
IG_like 41..118 CDD:214653 17/85 (20%)
IG_like 145..218 CDD:214653 25/86 (29%)
Ig 147..219 CDD:299845 25/85 (29%)
I-set 224..323 CDD:254352 17/107 (16%)
IGc2 236..314 CDD:197706 13/85 (15%)
FN3 339..431 CDD:238020 17/99 (17%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3510
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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