DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment DSCAM and Dscam1

DIOPT Version :9

Sequence 1:NP_001380.2 Gene:DSCAM / 1826 HGNCID:3039 Length:2012 Species:Homo sapiens
Sequence 2:NP_001246162.1 Gene:Dscam1 / 35652 FlyBaseID:FBgn0033159 Length:2038 Species:Drosophila melanogaster


Alignment Length:2041 Identity:610/2041 - (29%)
Similarity:954/2041 - (46%) Gaps:178/2041 - (8%)


- Green bases have known domain annotations that are detailed below.


Human    26 FVNASLQEVVFASTTGTLVPCPAAGIPPVTLRWYLATGEEIYDVPGIRHVHPNGTLQIFPFPPSS 90
            |:......:.|:::||..:.|.|:|.|...:.|..:.|..:.||||:|.:..:|.|...||....
  Fly    41 FLKEPTNRIDFSNSTGAEIECKASGNPMPEIIWIRSDGTAVGDVPGLRQISSDGKLVFPPFRAED 105

Human    91 FSTLIHDNTYYCTAENPSGKIRSQDVHIKAVLREPYTVRVEDQKTMRGNVAVFKCIIPSSVEAYI 155
            :...:|...|.|.|.|..|.|.|:|||::||:.:.|...:.....:|||.|:.||.|||.|..::
  Fly   106 YRQEVHAQVYACLARNQFGSIISRDVHVRAVVSQHYEEDIHKAFVIRGNSAILKCDIPSFVADFV 170

Human   156 TVVSWEKD-TVSLVSGS----RFLITSTGALYIKDVQNEDGLYNYRCITRHRYTGETRQS-NSAR 214
            .|:||..| ..:...|:    ::|:..:|.|:|::|..|||..:|:|.|:||.|||||.| ...|
  Fly   171 NVISWHSDEKENFYPGTEYDGKYLVLPSGELHIREVGPEDGYKSYQCRTKHRLTGETRLSATKGR 235

Human   215 LFVSDPANSAPSILDGFDHRKAMAGQR------VELPCKALGHPEPDYRWLK------DNMPLEL 267
            |.:::|..|....|.|..:::.:...|      |.|.|.|..:|.|.:||.|      ....:.|
  Fly   236 LVITEPVGSVSPQLSGNGNQEHITLTRVPKMGSVTLMCPAQAYPVPFFRWYKFIEGTTRKQAVVL 300

Human   268 SGRFQKTVTGLLIENIRPSDSGSYVCEVSNRYGTAKVIGRLYVKQPLKATISPRKVKSSVGSQVS 332
            :.|.::....|:|::....|||.|:|.|:|..|...|...|.|..||.|.|.|.......|....
  Fly   301 NDRVKQVSGTLIIKDAVVEDSGKYLCVVNNSVGGESVETVLTVTAPLSAKIDPPTQTVDFGRPAV 365

Human   333 LSCSVTGTEDQELSWYRNGEILNPGKNVRITGINHENLIMDHMVKSDGGAYQCFVRKDKLSAQDY 397
            .:|..||...:.:||.::|:.:...:.|         |.::.:.|.|.|.||||||.|:.||:..
  Fly   366 FTCQYTGNPIKTVSWMKDGKAIGHSEPV---------LRIESVKKEDKGMYQCFVRNDQESAEAS 421

Human   398 VQVVL--EDGTPKIISAFSEKVVSPAEPVSLMCNVKGTPLPTITWTLDDDPILKGGSHRISQMIT 460
            .::.|  ....|.|..||.|:.:.|...|.|.|...|.|.|.|:|.||...|.....:::.|.:|
  Fly   422 AELKLGGRFDPPVIRQAFQEETMEPGPSVFLKCVAGGNPTPEISWELDGKKIANNDRYQVGQYVT 486

Human   461 SEGNVVSYLNISSSQVRDGGVYRCTANNSAGVVLYQARINVRGPASIRPMKNITAIAGRDTYIHC 525
            ..|:|||||||:|....|||:|:|.|.:..||..:.|::||.|...||.|:....:||....:.|
  Fly   487 VNGDVVSYLNITSVHANDGGLYKCIAKSKVGVAEHSAKLNVYGLPYIRQMEKKAIVAGETLIVTC 551

Human   526 RVIGYPYYSIKWYKNSNLLPFNHRQVAFENNGTLKLSDVQKEVDEGEYTCNVLVQPQLSTSQSVH 590
            .|.|||..||.|.:::..||.|.:|..|. ||||.:.:|::..|:..|||....|...|...|:.
  Fly   552 PVAGYPIDSIVWERDNRALPINRKQKVFP-NGTLIIENVERNSDQATYTCVAKNQEGYSARGSLE 615

Human   591 VTVKVPPFIQPFEF-PRFSIGQRVFIPCVVVSGDLPITITWQKDGRPIPGSLGVTIDNI------ 648
            |.|.|.|.|.||.: ...::|..:.:.|.:..||.||.:.|..:..  .|..|  .|.:      
  Fly   616 VQVMVLPQIVPFAYEDLINMGDSIDLFCQIQKGDRPIKVHWSFERS--AGDYG--FDQVQPQMRT 676

Human   649 ----DFTSSLRISNLSLMHNGNYTCIARNEAAAVEHQSQLIVRVPPKFVVQPRDQDGIYGKAVIL 709
                :.||.:.|.:.|..|.|..||||.|:|....:...|.|.|||:::::|.|:....|....:
  Fly   677 NRISEKTSMISIPSASPAHTGRDTCIASNKAGTTTYSVDLTVNVPPRWILEPTDKAFAQGSDAKV 741

Human   710 NCSAEGYPVPTIVWKFSKGAGVPQFQPIALNGRIQVLSNGSLLIKHVVEEDSGYYLCKVSNDVGA 774
            .|.|:|:|.|.:.||.:.|....:::.:..:..|:| ..|:|.:.::.:.:.|||||:..|.:|:
  Fly   742 ECKADGFPKPQVTWKKAVGDTPGEYKDLKKSDNIRV-EEGTLHVDNIQKTNEGYYLCEAINGIGS 805

Human   775 DVSKSMYLTVKIPAMITSYPNTTLATQGQKKEMSCTAHGEKPIIVRWEKEDRIINPEM-ARYLVS 838
            .:|..:.::|:.|...|.......|.:|:...:.|.|.|||||.:.|...:..::|:. .||.:.
  Fly   806 GLSAVIMISVQAPPEFTEKLRNQTARRGEPAVLQCEAKGEKPIGILWNMNNMRLDPKNDNRYTIR 870

Human   839 TKEVGEEVISTLQILPTVREDSGFFSCHAINSYGEDRGIIQLTVQEPPDPP-EIEIKDVKARTIT 902
            .:.:...|:|:|.|..|.|.||..|:|.|.|::|.|...|.:.|||.|:.| .:::.|...|::.
  Fly   871 EEILSTGVMSSLSIKRTERSDSALFTCVATNAFGSDDASINMIVQEVPEMPYALKVLDKSGRSVQ 935

Human   903 LRWTMGFDGNSPITGYDIECKNKSDSWDSAQRTKDVSPQLNSATIIDIHPSSTYSIRMYAKNRIG 967
            |.|...:|||||:..|.||.|....||....|. .|......|.:..:.|::||:||:.|:|.||
  Fly   936 LSWAQPYDGNSPLDRYIIEFKRSRASWSEIDRV-IVPGHTTEAQVQKLSPATTYNIRIVAENAIG 999

Human   968 KSEPSNELTITADEAAPDGPPQEVHLEPISSQSIRVTWKAPKKHLQNGIIRGYQIGYREYSTGGN 1032
            .|:.|..:||...|.||.|.||.:.:||::..::|||||.|.:...||.|.||.:||:..:|..:
  Fly  1000 TSQSSEAVTIITAEEAPSGKPQNIKVEPVNQTTMRVTWKPPPRTEWNGEILGYYVGYKLSNTNSS 1064

Human  1033 FQFNIIS-VDTSGDSEVYTLDNLNKFTQYGLVVQACNRAGTGPSSQEIITTTLEDVPSYPPENVQ 1096
            :.|..|: :...|......|.||..:|||.:|:||.|:.|.||.|:|....|.|..||.||.:..
  Fly  1065 YVFETINFITEEGKEHNLELQNLRVYTQYSVVIQAFNKIGAGPLSEEEKQFTAEGTPSQPPSDTA 1129

Human  1097 AIATSPESISISWSTLSKEALNGILQGFRVIYWANLMDGELGEIKN--ITTTQPSLELDGLEKYT 1159
            ....:.::|.:.|.:...|:.||:::.::|:|..:  |....|.|.  ..|......|.||:|||
  Fly  1130 CTTLTSQTIRVGWVSPPLESANGVIKTYKVVYAPS--DEWYDETKRHYKKTASSDTVLHGLKKYT 1192

Human  1160 NYSIQVLAFTRAGDGVRSEQIFTRTKEDVPGPPAGVKAAAASASMVFVSWLPPLKLNGIIRKYTV 1224
            ||::||||.|..||||||..|..:|:.|||..|..|||.....:.:.|||.||.:.||||.:|||
  Fly  1193 NYTMQVLATTAGGDGVRSVPIHCQTEPDVPEAPTDVKALVMGNAAILVSWRPPAQPNGIITQYTV 1257

Human  1225 FCSHPYPTVISEFEASPD-SFSYRIPNLSRNRQYSVWVVAVTSAGRGNSSEIITVEPLAKAPARI 1288
            :.........::.:..|. ..|:....|.:|:.|..||.|.|:.|.|..|:.|...|..:.||:|
  Fly  1258 YSKAEGAETETKTQKVPHYQMSFEATELEKNKPYEFWVTASTTIGEGQQSKSIVAMPSDQVPAKI 1322

Human  1289 LTFSGTVTTPWMKDIVLPCKAVGDPSPAVKWMKDSNGTPSLVTIDGRRSIFSNGSFIIRTVKAED 1353
            .:|..|.|..:.:|..:||.|||.|.|.:.|  ...|..  .:.:.|..:..:||.:|::|..:|
  Fly  1323 ASFDDTFTATFKEDAKMPCLAVGAPQPEITW--KIKGVE--FSANDRMRVLPDGSLLIKSVNRQD 1383

Human  1354 SGYYSCIANNNWGSDEIILNLQVQVPPDQPRLTVSKTTSSSITLSWLPGDNGGSSIRGYILQYSE 1418
            :|.|||.|.|:...|.|...|.|..||..|.:|:|.||:.::|:...|.:...:.:.||.|.|..
  Fly  1384 AGDYSCHAENSIAKDSITHKLIVLAPPQSPHVTLSATTTDALTVKLKPHEGDTAPLHGYTLHYKP 1448

Human  1419 DNSEQWGSFPISPSERSYRLENLKCGTWYKFTLTAQNGVGPGRISEIIEAKTLGKEPQFSKEQEL 1483
            :..| |.:..:|...:.:.:|.|.||:.|:...|..|.:|.|..|:|:..:|.|::|:. .|:..
  Fly  1449 EFGE-WETSEVSVDSQKHNIEGLLCGSRYQVYATGFNNIGAGEASDILNTRTKGQKPKL-PEKPR 1511

Human  1484 FASINTTRVRLNLIGWNDGGCPITSFTLEYRPFGTTVWT-TAQRTSLSKSYILYDLQEATWYELQ 1547
            |..:::..|.|:...|.|||||::.|.:|.:......|. .:.......:|::.||:.||||.|:
  Fly  1512 FIEVSSNSVSLHFKAWKDGGCPMSHFVVESKKRDQIEWNQISNNVKPDNNYVVLDLEPATWYNLR 1576

Human  1548 MRVCNSAGCAEKQANFATLNYDGSTIPPL------------IKSVVQNEEGLTTNEGLKMLVTIS 1600
            :...||||....:.:||||...|.||.||            |:......|.|..|..:.::.|:.
  Fly  1577 ITAHNSAGFTVAEYDFATLTVTGGTIAPLDDGSGHGNVHTRIRLPAWMPEWLDLNFMVPLIATVV 1641

Human  1601 CILVGVLLLFVLLLVVRRRRREQRLKRLRDAKSLAEMLMSKNTRTSDTLSKQQQTLR---MHIDI 1662
            .:.||:.::.|.|   .|||.:......:|.  ..:::.::......||.|::..||   .:|..
  Fly  1642 VVAVGICVVCVAL---SRRRADDMRGGQKDV--YYDVVYNQTMGPGATLDKRRPDLRDELGYIAP 1701

Human  1663 PRAQL------------LIEE-----RDTMETIDDRSTVLLTDADFGEAAKQKSLTVTHTVHY-- 1708
            |..:|            .|:.     |....|.|.|     .:.:..|..|...:.: |..||  
  Fly  1702 PNRKLPPVPGSNYNTCDRIKRGRGGLRSNHSTWDPR-----RNPNLYEELKAPPVPM-HGNHYGH 1760

Human  1709 ----------------QSVSQATGPLVDVSDARPGTNPTTRRNAKAGPTARNRYASQWTLNRPHP 1757
                            :....||..|:..   |...:||...|.:..| .:|.:|.      |.|
  Fly  1761 AHGNAECHYRHPGMEDEICPYATFHLLGF---REEMDPTKAMNFQTFP-HQNGHAG------PVP 1815

Human  1758 TISAHTLTTDWRLPTPRAAGSVDKESDSYSVSPSQDTDRARSSMVSTESASSTYEELARAYEHAK 1822
               .|..|   .|| |...|.|...|.|.|:..:....|..|.    ...||.|.......:.|.
  Fly  1816 ---GHAGT---MLP-PGHPGHVHSRSGSQSMPRANRYQRKNSQ----GGQSSIYTPAPEYDDPAN 1869

Human  1823 MEEQLRHAKFTITECFISDTSSEQLTAGTN-EYTDSLTSSTPSESGICRFTASPPKPQD----GG 1882
            ..|:.::.::|..     ::....|.:|.. ||.|....:...:....::.....:|.|    .|
  Fly  1870 CAEEDQYRRYTRV-----NSQGGSLYSGPGPEYDDPANCAPEEDQYGSQYGGPYGQPYDHYGSRG 1929

Human  1883 RVMNMAVPKAHRPGDLIHLPPYLRMDFLLNRGGPGTSRDLSLGQACLEPQKSRTLKRPTVLEPIP 1947
            .:...::..|..||:....||            |...|:..:..:.....|...           
  Fly  1930 SMGRRSIGSARNPGNGSPEPP------------PPPPRNHDMSNSSFNDSKESN----------- 1971

Human  1948 MEAASSASSTREGQSWQPGAVATLPQ 1973
             |.:.:......|.....|||...||
  Fly  1972 -EISEAECDRDHGPRGNYGAVKRSPQ 1996

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
DSCAMNP_001380.2 Ig 45..113 CDD:319273 22/67 (33%)
I-set 235..310 CDD:254352 24/86 (28%)
I-set 315..385 CDD:333254 16/69 (23%)
Ig_3 407..488 CDD:316449 34/80 (43%)
IGc2 518..575 CDD:197706 21/56 (38%)
I-set 596..686 CDD:333254 27/100 (27%)
Ig_DSCAM 707..784 CDD:143211 20/76 (26%)
Ig 802..889 CDD:325142 31/87 (36%)
FN3 885..978 CDD:238020 32/93 (34%)
FN3 986..1083 CDD:238020 37/97 (38%)
FN3 1091..1184 CDD:238020 33/94 (35%)
FN3 1189..1278 CDD:238020 30/89 (34%)
Ig 1303..1369 CDD:319273 21/65 (32%)
FN3 1380..1470 CDD:238020 26/89 (29%)
FN3 1486..1555 CDD:238020 21/69 (30%)
Required for netrin-mediated axon repulsion of neuronal growth cones. /evidence=ECO:0000250|UniProtKB:Q9ERC8 1617..2012 75/400 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1718..1810 23/91 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1855..1883 3/31 (10%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1971..2012 2/3 (67%)
Dscam1NP_001246162.1 Ig 38..130 CDD:299845 27/88 (31%)
IG 57..133 CDD:214652 25/75 (33%)
IG_like 267..343 CDD:214653 23/75 (31%)
Ig 269..340 CDD:143165 22/70 (31%)
IG_like 353..425 CDD:214653 22/80 (28%)
IGc2 361..413 CDD:197706 17/60 (28%)
I-set 433..527 CDD:254352 37/93 (40%)
IGc2 446..517 CDD:197706 29/70 (41%)
I-set 533..618 CDD:254352 31/85 (36%)
IGc2 544..607 CDD:197706 24/63 (38%)
Ig 641..714 CDD:143165 21/76 (28%)
IGc2 735..804 CDD:197706 19/69 (28%)
I-set 819..914 CDD:254352 29/94 (31%)
Ig 833..921 CDD:299845 31/87 (36%)
FN3 918..1011 CDD:238020 33/93 (35%)
FN3 1018..1116 CDD:238020 37/97 (38%)
FN3 1124..1217 CDD:238020 33/94 (35%)
FN3 1222..1312 CDD:238020 30/89 (34%)
Ig 1339..1406 CDD:299845 24/70 (34%)
FN3 1409..1499 CDD:238020 27/90 (30%)
FN3 1504..1584 CDD:238020 24/80 (30%)
Dscam_C 1890..2008 CDD:289151 22/131 (17%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 137 1.000 Domainoid score I4888
eggNOG 1 0.900 - - E1_KOG3510
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 968 1.000 Inparanoid score I322
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG47134
OrthoDB 1 1.010 - - D10185at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - mtm8541
orthoMCL 1 0.900 - - OOG6_101656
Panther 1 1.100 - - O PTHR10075
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X1391
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1211.840

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