DRSC/TRiP Functional Genomics Resources

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Protein Alignment DSCAM and bdl

DIOPT Version :9

Sequence 1:NP_001380.2 Gene:DSCAM / 1826 HGNCID:3039 Length:2012 Species:Homo sapiens
Sequence 2:NP_608822.1 Gene:bdl / 33635 FlyBaseID:FBgn0028482 Length:719 Species:Drosophila melanogaster


Alignment Length:724 Identity:168/724 - (23%)
Similarity:266/724 - (36%) Gaps:210/724 - (29%)


- Green bases have known domain annotations that are detailed below.


Human   434 PLP-TITWTLDDDPILKGGSHR--ISQMITSEGNVV--------SYLNISSSQVRDGGVYRCTA- 486
            |:| .:.||.|:..|.......  .|::.....::|        :.:|:::.:..|.|.|.|.. 
  Fly    64 PIPYLVHWTKDNKKIFTWYEQETSTSELFNGRLHLVENHPEFGRASVNLTAIRESDQGWYHCQVS 128

Human   487 --NNSAGV----VLYQARINVRGPASIR-PMKNITAIAGRDTYIHCRVIGYPYYS-IKWYKNSNL 543
              |.|..|    ..|  .:.|:|.:.|| |..|.|...|:..:.|| |:.:|..| ..|||:..|
  Fly   129 FPN
RSPSVRNNGTAY--HLAVQGGSLIRIPPVNQTIREGQTAFFHC-VMKHPENSQASWYKDGVL 190

Human   544 LPFNH---RQVAFENNGTLKLSDVQKEVDEGEYTCNVL-VQPQLSTSQ---SVHVTVKV----PP 597
            |....   |:.....:|:|.: |.....|.|||.|.|. ...:|.|::   ::....||    |.
  Fly   191 LQEVQDLVRRFYMGPDGSLSI-DPTMMSDLGEYECKVRNSDGELQTAKAFLNI
QYKAKVIYAPPE 254

Human   598 FIQPFEFPRFSIGQRVFIPCVVVSGDLPITITWQKDG-----RPIPGSLGVTIDNIDFTSSLRIS 657
            ...|:       ||...:.|...:......:.|:|||     ..:||..      .....||..:
  Fly   255 VFLPY-------GQPAVLDCHFRANPPLKNLRWEKDGLLFDSYNVPGVF------YKMNGSLFFA 306

Human   658 NLSLMHNGNYTCIARNEAAAVEHQS---QLIVRVPPKFVVQPRDQDGIY----GKAVILNCSA-- 713
            .:...|.|:|||...|: ...:..|   .:||..||.|.|.|:   .||    |:|..|.|.|  
  Fly   307 KVDENHAGSYTCTPYND-LGTDGPSPVISVIV
LRPPIFSVTPK---AIYIQKLGEAAELPCEAID 367

Human   714 -EGYPVPTIVWKFSKGAGVP--QFQPIALNGRIQVLSNGSLLIKHVVEEDSGYYLCKVSNDVGAD 775
             :|...|:|:|....|..:|  :|.          ||.|:|.|..:||.|.|.|.|..:|: .|.
  Fly   368 RDGNNRPSIIWGRKDGQPLPADRFS----------LSGGNLTITGLVEGDRGIYECSATNE-AAT 421

Human   776 VSKSMYLTVKIPAMITSYPNTTLATQGQKKEMSCTAHGEKPIIVRWEKEDRIINPEMARYLVSTK 840
            ::....|.::..|....|..|..:|:      :|       |.:||  :...:.|.: .|.|..:
  Fly   422 ITAEAEL
MIENIAPRAPYNLTANSTE------TC-------ITIRW--QPGYLRPNL-EYTVWYR 470

Human   841 EVGEEVISTLQILPTVREDSGFFSCHAINSYGEDRGIIQLTVQEPPDPPEIEI------------ 893
            .:......||::|                    |:.:::.|||......|.|.            
  Fly   471 LMEAPEWRTLRVL--------------------DKKVMEATVQHLQPGKEYEFMVLSQDKYGDGM 515

Human   894 --KDVKARTITLRWTMGFDGNSPITGYDIECKNKSDSWDSAQRTKDVSPQLNSATIIDIHPSSTY 956
              |..:.:|:.          |||         ::|.:|:.|...|    |...|.    |:.  
  Fly   516 FSKQFRFQTLP----------SPI---------RADDFDAQQLQHD----LGQVTA----PAG-- 551

Human   957 SIRMYAKNRIGKSEPSNELTITADEAA----PDGPPQEVHLEPISSQSIRVTWKAPKKHLQNGII 1017
                      |...|.| ||..:::..    .:.|.|  .||.:...::| .||.|:..|     
  Fly   552 ----------GLGAPWN-LTAISNQQGWLLHWEHPVQ--GLEGLRLYAVR-WWKEPEHFL----- 597

Human  1018 RGYQIGYREYSTGGNFQFNIISVDTSGDSEVYTLDNLNKFTQYGLVVQACNRAGTGPSSQEIITT 1082
                ||:.|  |..|:               |.|.:|.:.|.:.:.|.|     .|..:|:.:.:
  Fly   598 ----IGHAE--TFDNY---------------YQLRHLKEDTLFKVQVLA-----VGTETQQSVPS 636

Human  1083 --TLEDVPS 1089
              .|.||||
  Fly   637 HELLIDVPS 645

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
DSCAMNP_001380.2 Ig 45..113 CDD:319273
I-set 235..310 CDD:254352
I-set 315..385 CDD:333254
Ig_3 407..488 CDD:316449 13/67 (19%)
IGc2 518..575 CDD:197706 19/60 (32%)
I-set 596..686 CDD:333254 20/97 (21%)
Ig_DSCAM 707..784 CDD:143211 24/81 (30%)
Ig 802..889 CDD:325142 14/86 (16%)
FN3 885..978 CDD:238020 19/106 (18%)
FN3 986..1083 CDD:238020 22/98 (22%)
FN3 1091..1184 CDD:238020
FN3 1189..1278 CDD:238020
Ig 1303..1369 CDD:319273
FN3 1380..1470 CDD:238020
FN3 1486..1555 CDD:238020
Required for netrin-mediated axon repulsion of neuronal growth cones. /evidence=ECO:0000250|UniProtKB:Q9ERC8 1617..2012
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1718..1810
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1855..1883
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1971..2012
bdlNP_608822.1 IG_like 42..128 CDD:214653 13/63 (21%)
Ig 43..131 CDD:299845 13/66 (20%)
I-set 153..242 CDD:254352 28/90 (31%)
Ig 157..242 CDD:299845 25/86 (29%)
Ig_2 252..337 CDD:290606 20/98 (20%)
IG_like 260..327 CDD:214653 17/73 (23%)
I-set 341..428 CDD:254352 31/100 (31%)
IGc2 356..419 CDD:197706 24/73 (33%)
FN3 435..524 CDD:238020 20/124 (16%)
FN3 554..636 CDD:238020 26/116 (22%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3510
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR10075
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.910

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