DRSC/TRiP Functional Genomics Resources

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Protein Alignment DSCAM and dpr3

DIOPT Version :9

Sequence 1:NP_001380.2 Gene:DSCAM / 1826 HGNCID:3039 Length:2012 Species:Homo sapiens
Sequence 2:NP_001014459.2 Gene:dpr3 / 3346208 FlyBaseID:FBgn0053516 Length:522 Species:Drosophila melanogaster


Alignment Length:239 Identity:47/239 - (19%)
Similarity:79/239 - (33%) Gaps:75/239 - (31%)


- Green bases have known domain annotations that are detailed below.


Human   511 KNITAIAGR-DTYIHCRVIGYPYYSIKWYKNSNLLPFNHRQVAFENNGTLKLSDVQKE------- 567
            :|||...|. :..|.|||......|:.|.:..:|.........:.::...::::.:..       
  Fly   244 RNITGRTGHTEAIIKCRVDSLHDKSVSWIRKRDLHILTVGTATYTSDKRFQVTESKDSREWTLHV 308

Human   568 -----VDEGEYTCNVLVQPQLSTSQSVHV---------TVKVPPFIQPFEFPRFSIGQRVFIPCV 618
                 .|.|.|.|.|..:|::|.:..:::         .:..||.:      .|..|..:.:.|:
  Fly   309 KAPLAKDSGIYECQVNTEPKMSMAFQLNIIEISPDAKAVISGPPDL------HFKAGSAIILNCL 367

Human   619 V-------------VSGDLPITITWQKDGRP-IPGSLGV-------------TIDNID------- 649
            |             ..|:..||.....||:| ||...|.             .:..:|       
  Fly   368 VQQPSVKDIGPIYWYRGEHMITPFDADDGQPEIPAGRGEHPQGIPEDTSPNDIMSEVDLQMEFAT 432

Human   650 -----------FTSSLRISNLSLMHNGNYTC--IARNEAAAVEH 680
                       ..|.|||||......|||||  ...:.|:.:.|
  Fly   433 RIAMESQLGDTLKSRLRISNAQTTDTGNYTCQPTTASSASVLVH 476

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
DSCAMNP_001380.2 Ig 45..113 CDD:319273
I-set 235..310 CDD:254352
I-set 315..385 CDD:333254
Ig_3 407..488 CDD:316449
IGc2 518..575 CDD:197706 11/69 (16%)
I-set 596..686 CDD:333254 29/132 (22%)
Ig_DSCAM 707..784 CDD:143211
Ig 802..889 CDD:325142
FN3 885..978 CDD:238020
FN3 986..1083 CDD:238020
FN3 1091..1184 CDD:238020
FN3 1189..1278 CDD:238020
Ig 1303..1369 CDD:319273
FN3 1380..1470 CDD:238020
FN3 1486..1555 CDD:238020
Required for netrin-mediated axon repulsion of neuronal growth cones. /evidence=ECO:0000250|UniProtKB:Q9ERC8 1617..2012
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1718..1810
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1855..1883
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1971..2012
dpr3NP_001014459.2 Ig 243..330 CDD:299845 17/85 (20%)
IG_like 243..329 CDD:214653 17/84 (20%)
Ig 350..464 CDD:299845 26/119 (22%)
IG_like <441..477 CDD:214653 13/36 (36%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3510
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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