DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DSCAM and dpr8

DIOPT Version :9

Sequence 1:	NP_001380.2	Gene:	DSCAM / 1826	HGNCID:	3039	Length:	2012	Species:	Homo sapiens
Sequence 2:	NP_001285239.1	Gene:	dpr8 / 32387	FlyBaseID:	FBgn0052600	Length:	344	Species:	Drosophila melanogaster

Alignment Length:	204	Identity:	50/204 - (24%)
Similarity:	85/204 - (41%)	Gaps:	44/204 - (21%)

- Green bases have known domain annotations that are detailed below.

Human   327 VGSQVSLSCSVTGTEDQELSWYRNGEI--LNPGKNVRITGINHENLIMDH----------MVKSD 379
            ||..|.|:|.|....::.:||.|:.:|  |..|:....:....|.:...|          ..:.|
  Fly    56 VGKTVKLTCRVKNLGNRTVSWVRHRDIHLLTVGRYTYTSDQRFEAMHSPHAEDWTLRIRYAQRKD 120

Human   380 GGAYQCFV-RKDKLSAQDYVQVVLEDGTPKIISAFSEKVVSPAEPVSLMCNVK--GTPLPTITWT 441
            .|.|:|.: ....:....|:.:|  :....||.. .|..::....::|.|.||  ..|.||:.|:
  Fly   121 SGIYECQISTTPPIGHSVYLNIV--EPVTDIIGG-PELHINRGSTINLTCIVKFAPEPPPTVIWS 182

Human   442 LD------DDPILKGGSHRISQMITSEGNV-VSYLNISSSQVRDGGVYRCTANNSAGVVLYQARI 499
            .:      |.|  :||   || ::|.:|.: .|.|.:..:..:|.|:|.||.:|:
  Fly   183 HNREIINFDSP--RGG---IS-LVTEKGVLTTSRLLVQKAITQDSGLYTCTPSNA---------- 231

Human   500 NVRGPASIR 508
               .|.|:|
  Fly   232 ---NPTSVR 237

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DSCAM	NP_001380.2	Ig	45..113	CDD:319273
		I-set	235..310	CDD:254352
		I-set	315..385	CDD:333254	17/69 (25%)
		Ig_3	407..488	CDD:316449	26/89 (29%)
		IGc2	518..575	CDD:197706
		I-set	596..686	CDD:333254
		Ig_DSCAM	707..784	CDD:143211
		Ig	802..889	CDD:325142
		FN3	885..978	CDD:238020
		FN3	986..1083	CDD:238020
		FN3	1091..1184	CDD:238020
		FN3	1189..1278	CDD:238020
		Ig	1303..1369	CDD:319273
		FN3	1380..1470	CDD:238020
		FN3	1486..1555	CDD:238020
		Required for netrin-mediated axon repulsion of neuronal growth cones. /evidence=ECO:0000250\|UniProtKB:Q9ERC8	1617..2012
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1718..1810
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1855..1883
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1971..2012
dpr8	NP_001285239.1	IG_like	51..131	CDD:214653	18/74 (24%)
		V-set	52..143	CDD:284989	19/86 (22%)
		IG_like	153..238	CDD:214653	28/104 (27%)
		ig	153..232	CDD:278476	25/97 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810