DRSC/TRiP Functional Genomics Resources

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Protein Alignment DSCAM and DIP-kappa

DIOPT Version :9

Sequence 1:NP_001380.2 Gene:DSCAM / 1826 HGNCID:3039 Length:2012 Species:Homo sapiens
Sequence 2:NP_723828.1 Gene:DIP-kappa / 318958 FlyBaseID:FBgn0051814 Length:672 Species:Drosophila melanogaster


Alignment Length:648 Identity:134/648 - (20%)
Similarity:204/648 - (31%) Gaps:232/648 - (35%)


- Green bases have known domain annotations that are detailed below.


Human   504 PASIRPMKNITAIAGRDTYIHCRVIGYPYYSIKWYK--NSNLLPFNHRQVAFENNGTLKLSDVQ- 565
            |....|:.|:|...|||..:.|.|.....|.:.|.:  ...:|..:|..::..:..:|..:|.: 
  Fly    74 PRFAEPIANVTVSVGRDALMACVVENLKGYKVAWVRVDTQTILSIHHNVISQNSRISLTYNDHRS 138

Human   566 --------KEVDEGEYTCNVLVQPQLSTSQSVHVTVKVPPFIQPFEFPRFSIGQRVFIPCVVVSG 622
                    :|.|.|.|.|.|...|.  .|:..::.|.|||                    ::|.|
  Fly   139 WYLHIKEVEETDRGWYMCQVNTDPM--RSRKGYLQVVVPP--------------------IIVEG 181

Human   623 DLPITITWQKDGRPIPGSLGVTIDNIDFTSSLRISNLSLMHNGNYTCIARNEAAAVEHQSQLIVR 687
                                       .||                             :.::||
  Fly   182 ---------------------------LTS-----------------------------NDMVVR 190

Human   688 VPPKFVVQPRDQDGIYGKAVILNCSAEGYPVPTIVWKFSKGAGVPQFQPIALNGRIQVLSNGSLL 752
                           .|:.:.|.|.|.|||.|.::|:...|      :.:.:.|....:.:|.||
  Fly   191 ---------------EGQNISLVCKARGYPEPYVMWRREDG------EEMLIGGEHVNVVDGELL 234

Human   753 -IKHVVEEDSGYYLCKVSNDVGADVSKSMYLTVKIPAMITSYPNTTL-ATQGQKKEMSCTAHGEK 815
             |..|.......|||..||.|...:||.::|.|:.|.|: |.||... |..||...:.|......
  Fly   235 HITKVSRLHMAAYLCVASNGVPPSISKRVHLRVQFPPML-SIPNQLEGAYLGQDVILECHTEAYP 298

Human   816 PIIVRW--EKEDRIINPEMARYLVSTKEVGE--EVIST---------LQILPTVREDSGFFSCHA 867
            ..|..|  |:.|.||:        .|...|:  |..||         |:|......|.|.:.|.|
  Fly   299 ASINYWTTERGDMIIS--------DTSRAGDKYETTSTVSGYTKYMKLKIRAVGPNDFGTYRCVA 355

Human   868 INSYGEDRGIIQLTVQEPPDPPEIEIKDVKARTITL----RWTMGFDGNSPITGYDIECKNKSDS 928
            .||.||..|.|:|  .|.|.|....|.::.....:.    |....||..:.:..|.:|      .
  Fly   356 KNSLGETDGNIKL--DEMPTPTTAIISEMSLLNRSYDGKRRHRNKFDSANALPDYGVE------E 412

Human   929 W-DSAQRTKDVSPQLNSATIIDIHPSSTYSIRMYAKNRIGKSEPSNELTITADEAAPDGPPQEVH 992
            | |.||                             .|..|.:..:|:..:.       .||...|
  Fly   413 WRDGAQ-----------------------------GNNAGNNGDNNQTPVR-------NPPGAFH 441

Human   993 LEPISSQSIRVTWKAPKKHLQNGIIRGYQIGYREYSTGGNFQFNIISVDTSGDSEVYTLDNLNKF 1057
               .|:.|:          .|:.::....:|.:..|.|                       :.|.
  Fly   442 ---NSAGSL----------AQHNLLAKIMLGIKTQSFG-----------------------IFKR 470

Human  1058 TQYGLVVQACNRAGTGPSSQEIITTTLEDVPS-YPPENVQAIATSPESI------SISWSTLS 1113
            ....|.:.|      |.|...:.|.:|...|| :...||:....|||::      :..|.|.|
  Fly   471 LSSSLPLAA------GQSFLWLSTLSLVSAPSRWRMSNVENRPNSPETVVNNDTAAECWETRS 527

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
DSCAMNP_001380.2 Ig 45..113 CDD:319273
I-set 235..310 CDD:254352
I-set 315..385 CDD:333254
Ig_3 407..488 CDD:316449
IGc2 518..575 CDD:197706 15/67 (22%)
I-set 596..686 CDD:333254 6/89 (7%)
Ig_DSCAM 707..784 CDD:143211 24/77 (31%)
Ig 802..889 CDD:325142 29/99 (29%)
FN3 885..978 CDD:238020 15/97 (15%)
FN3 986..1083 CDD:238020 15/96 (16%)
FN3 1091..1184 CDD:238020 8/29 (28%)
FN3 1189..1278 CDD:238020
Ig 1303..1369 CDD:319273
FN3 1380..1470 CDD:238020
FN3 1486..1555 CDD:238020
Required for netrin-mediated axon repulsion of neuronal growth cones. /evidence=ECO:0000250|UniProtKB:Q9ERC8 1617..2012
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1718..1810
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1855..1883
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1971..2012
DIP-kappaNP_723828.1 Ig 80..172 CDD:299845 21/93 (23%)
IG_like 82..174 CDD:214653 22/93 (24%)
IG_like 184..267 CDD:214653 28/132 (21%)
IGc2 191..255 CDD:197706 21/69 (30%)
IG_like 282..368 CDD:214653 27/93 (29%)
Ig 288..367 CDD:143165 23/86 (27%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3510
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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