DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DSCAM and kirre

DIOPT Version :9

Sequence 1:	NP_001380.2	Gene:	DSCAM / 1826	HGNCID:	3039	Length:	2012	Species:	Homo sapiens
Sequence 2:	NP_001245505.1	Gene:	kirre / 31292	FlyBaseID:	FBgn0028369	Length:	956	Species:	Drosophila melanogaster

Alignment Length:	601	Identity:	128/601 - (21%)
Similarity:	207/601 - (34%)	Gaps:	146/601 - (24%)

- Green bases have known domain annotations that are detailed below.

Human   318 ISPRKVKSSVGSQVSLSCSV---TGT-----EDQELSWYRNGEILNPGKNVRITGINHE---NLI 371
            :.|:...:.|||:|:|.|.|   .|.     :|..|..:||   |:..:...:.|.:.|   :|.
  Fly    86 MEPQDQTAVVGSRVTLPCRVMEKVGALQWTKDDFGLGQHRN---LSGFERYSMVGSDEEGDFSLD 147

Human   372 MDHMVKSDGGAYQCFVRKDKLSAQDY------VQVVLEDGTPKIISAFSEKVVSPAEPVSLMC-N 429
            :..::..|...|||.|.......|..      :.|::....|||... ...|.:....:.|.| :
  Fly   148 IYPLMLDDDAKYQCQVGPGPQGEQGIRSRFAKLTVLVPPEAPKITQG-DYLVTTEDREIELECVS 211

Human   430 VKGTPLPTITWTLDDDPILKGGSHRISQMITSEGNVV--SYLNISSSQVRDGGVYRCTANNSAGV 492
            ..|.|...|||......:|..|...:.:.:.....:.  |.|.::..:......:.|.|.|:|.
  Fly   212 QGGKPAAEITWIDGLGNVLTKGIEYVKEPLADSRRITARSILKLAPKKEHHNTTFTCQAQNTAD- 275

Human   493 VLYQARINVRGPASIRPMKNITAIAGRDTYIHCRVIGYPYYSIKWYKNSNLLPFNHRQVAFENNG 557
                                                       :.|:::.||.
  Fly   276 -------------------------------------------RTYRSAKLLL------------ 285

Human   558 TLKLSDVQKEVDEGEYTCNVLVQPQLSTSQSVHVTVKVPPFIQPFEFPRFSIGQRVFIPCVVVSG 622
                        |.:|...|:|    |.........|:|.            |..|.:.|...:.
  Fly   286 ------------EVKYAPKVIV----SVVGGALAGGKIPE------------GAEVILSCQADAN 322

Human   623 DLPITITWQKDGRPIPGSLGVTIDNIDFTSSLRISNLSLM-HNGNYTCIARNEAAAVEHQSQLIV 686
            ...::..|..:...:.|         |||:.:.|.|:|.. |:....|...|.....|...:|.:
  Fly   323 PHELSYRWFINDELMTG---------DFTTKMIIHNVSRQYHDAIVKCEVVNAVGKSEQSKKLDI 378

Human   687 RVPPKFVVQPRDQDGIYGKAVILNCSAEGYPVPTIVWKFSKGAGVPQFQPIALNGRIQVLSNGSL 751
            ...|.|..:|...:...|..|.:.|...|.|.|.|.|             |:.|.. ||:...:.
  Fly   379 SFGPVFRQRPVSVEADLGATVSMRCDVAGNPEPEIEW-------------ISENSD-QVVGVAAE 429

Human   752 LIKHVVEEDSGYYLCK-VSN---DVGADVSKSMYLTVKIPAMITSYPNTTLATQGQKKEMSCTAH 812
            |...|..|.:|.|.|| |.|   ::||:.:    |.||...:|||: .......|.:.::.|.|.
  Fly   430 LKLKVSSETAGRYFCKAVVNGFPEIGAEAT----LYVKRAPIITSH-KVQFGGVGGRVKIDCLAF 489

Human   813 G-EKPIIVRWEKEDRIINPEMAR---YLVSTKEVGEEVISTLQILPTVREDSGFFSCHAINSYGE 873
            . .|...:.|..|.:|||...|.   |:.....:.|.|.:.|.|..:.....|.::|..:||||.
  Fly   490 SIPKAEHILWSFEGKIINMSSADPDIYIFEEHHLPEGVRAALIIRDSKATHFGKYNCTVMNSYGG 554

Human   874 DRGIIQLTVQEPPDPP 889
            |..:|.| ::||.:.|
  Fly   555 DSLVITL-LREPGNIP 569

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DSCAM	NP_001380.2	Ig	45..113	CDD:319273
		I-set	235..310	CDD:254352
		I-set	315..385	CDD:333254	19/77 (25%)
		Ig_3	407..488	CDD:316449	17/83 (20%)
		IGc2	518..575	CDD:197706	5/56 (9%)
		I-set	596..686	CDD:333254	17/90 (19%)
		Ig_DSCAM	707..784	CDD:143211	23/80 (29%)
		Ig	802..889	CDD:325142	26/90 (29%)
		FN3	885..978	CDD:238020	2/5 (40%)
		FN3	986..1083	CDD:238020
		FN3	1091..1184	CDD:238020
		FN3	1189..1278	CDD:238020
		Ig	1303..1369	CDD:319273
		FN3	1380..1470	CDD:238020
		FN3	1486..1555	CDD:238020
		Required for netrin-mediated axon repulsion of neuronal growth cones. /evidence=ECO:0000250\|UniProtKB:Q9ERC8	1617..2012
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1718..1810
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1855..1883
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1971..2012
kirre	NP_001245505.1	Ig	87..183	CDD:299845	23/98 (23%)
		IG_like	88..182	CDD:214653	23/96 (24%)
		C2-set_2	189..279	CDD:285423	19/134 (14%)
		Ig_2	307..379	CDD:290606	17/92 (18%)
		I-set	382..462	CDD:254352	27/97 (28%)
		IGc2	396..446	CDD:197706	18/63 (29%)
		Ig	466..561	CDD:299845	26/95 (27%)
		IG_like	478..561	CDD:214653	23/82 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810