DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DSCAM and rst

DIOPT Version :9

Sequence 1:	NP_001380.2	Gene:	DSCAM / 1826	HGNCID:	3039	Length:	2012	Species:	Homo sapiens
Sequence 2:	NP_001284835.1	Gene:	rst / 31290	FlyBaseID:	FBgn0003285	Length:	764	Species:	Drosophila melanogaster

Alignment Length:	792	Identity:	162/792 - (20%)
Similarity:	250/792 - (31%)	Gaps:	283/792 - (35%)

- Green bases have known domain annotations that are detailed below.

Human   514 TAIAGRDTYIHCRVIGYPYYSIKWYKNS-------NLLPF-NHRQVAFENNGTLKLSDVQKEV-- 568
            ||:.|....:.||||. ...:::|.|:.       :|..| .:..|..:..|...| |:...:
  Fly    38 TAVVGARVTLPCRVIN-KQGTLQWTKDDFGLGTSRDLSGFERYAMVGSDEEGDYSL-DIYPVMLD 100

Human   569 DEGEYTCNVLVQPQ---LSTSQSVHVTVKVPPFIQPFEFPRFSIG--------QRVFIPCVVVSG 622
            |:..|.|.|...|:   ...|....:||.|||     |.|:.:.|        ::|.|.||.|.|
  Fly   101 DDARYQCQVSPGPEGQPAIRSTFAGLTVLVPP-----EAPKITQGDVIYATEDRKVEIECVSVGG 160

Human   623 DLPITITWQKDGRPIPGSLGVTIDNIDFT-------------SSLRISNLSLMHNGNYTCIARNE 674
            .....|||      |.|...|..|||::|             |.||::.....||.|::|.|:|.
  Fly   161 KPAAEITW------IDGLGNVLTDNIEYTVIPLPDQRRFTAKSVLRLTPKKEHHNTNFSCQAQNT 219

Human   675 A-------------------------------------------------AAVEH---------- 680
            |                                                 ..|||
  Fly   220 ADRTYRSAKIRVEVKYAPKVKVNVMGSLPGGAGGSVGGAGGGSVHMSTGSRIVEHSQVRLECRAD 284

Human   681 ---------------------QSQLIVR-------------------------------VPPKFV 693
                                 ::::::|                               ..|.|.
  Fly   285 ANPSDVRYRWFINDEPIIGGQKTEMVIRNVTRKFHDAIVKCEVQNSVGKSEDSETLDISYAPSFR 349

Human   694 VQPRDQDGIYGKAVILNCSAEGYPVPTIVWKFSKGAGVPQFQPIALNGRIQ-----VLSNGSLLI 753
            .:|:..:...|..|.|.|..:..|.|.|||                   ||     |:...:.|.
  Fly   350 QRPQSMEADVGSVVSLTCEVDSNPQPEIVW-------------------IQHPSDRVVGTSTNLT 395

Human   754 KHVVEEDSGYYLCKVSNDVGADVSKSMYLTVKIPAMITSYPNTTLATQGQKKEMSCTAHG-EKPI 817
            ..|..|.:|.|.||.:....|::|...|:.:|....|.| ..|.....|....:.|.|.. .:..
  Fly   396 FSVSNETAGRYYCKANVPGYAEISADAYVYLKGSPAIGS-QRTQYGLVGDTARIECFASSVPRAR 459

Human   818 IVRWEKEDRIINPEMAR-YLVSTKEVGEEVISTLQILPTVREDSGFFSCHAINSYGEDRGIIQLT 881
            .|.|....:.|:.|... |.:....|...|.|||.|..:.....|.::|..:|.||.|...|||.
  Fly   460 HVSWTFNGQEISSESGHDYSILVDAVPGGVKSTLIIRDSQAYHYGKYNCTVVNDYGNDVAEIQLQ 524

Human   882 VQEPPDPPEIEIKDVKARTITLRWTMGFDGNSPITGY----------DIECKNK-----SDSWDS 931
            .:               ::::|..|:  .|...:..:          .|:||.:     :|....
  Fly   525 AK---------------KSVSLLMTI--VGGISVVAFLLVLTILVVVYIKCKKRTKLPPADVISE 572

Human   932 AQRTKD--VSPQLN--------SATIIDI------------HPS------STYSIRMYAKNRIGK 968
            .|.||:  ||.:|.        |...:||            |.|      :|.|.:....:.|.:
  Fly   573 HQITKNGGVSCKLEPGDRTSNYSDLKVDISGGYVPYGDYSTHYSPPPQYLTTCSTKSNGSSTIMQ 637

Human   969 SEPSNELTITADEAAPDGPPQEVHLEPISSQSIRVTWKAPKKHLQNGIIRGYQIGYREYSTGGNF 1033
            :...|:|.:...:       |:.|     .|....|...|...|.|             |:||:.
  Fly   638 NNHQNQLQLQQQQ-------QQSH-----HQHHTQTTTLPMTFLTN-------------SSGGSL 677

Human  1034 QFNIISVDTSGDSEVYTLDNLNKF--TQYGLVVQACNRAGTGPSSQEIITTTLE-DVPSYPPENV 1095
            ..:||     |..|:...:.|...  |...:|..:.|.:.:..|:....|||.. .|||     .
  Fly   678 TGSII-----GSREIRQDNGLPSLQSTTASVVSSSPNGSCSNQSTTAATTTTTHVVVPS-----S 732

Human  1096 QAIATSPESISI 1107
            .|::..|...:|
  Fly   733 MALSVDPRYSAI 744

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DSCAM	NP_001380.2	Ig	45..113	CDD:319273
		I-set	235..310	CDD:254352
		I-set	315..385	CDD:333254
		Ig_3	407..488	CDD:316449
		IGc2	518..575	CDD:197706	15/66 (23%)
		I-set	596..686	CDD:333254	34/190 (18%)
		Ig_DSCAM	707..784	CDD:143211	21/81 (26%)
		Ig	802..889	CDD:325142	23/88 (26%)
		FN3	885..978	CDD:238020	23/135 (17%)
		FN3	986..1083	CDD:238020	20/98 (20%)
		FN3	1091..1184	CDD:238020	3/17 (18%)
		FN3	1189..1278	CDD:238020
		Ig	1303..1369	CDD:319273
		FN3	1380..1470	CDD:238020
		FN3	1486..1555	CDD:238020
		Required for netrin-mediated axon repulsion of neuronal growth cones. /evidence=ECO:0000250\|UniProtKB:Q9ERC8	1617..2012
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1718..1810
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1855..1883
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1971..2012
rst	NP_001284835.1	IG_like	34..130	CDD:214653	23/93 (25%)
		Ig	42..114	CDD:299845	17/73 (23%)
		C2-set_2	135..225	CDD:285423	28/95 (29%)
		Ig_3	265..329	CDD:290638	4/63 (6%)
		I-set	346..420	CDD:254352	23/92 (25%)
		Ig	360..425	CDD:299845	22/83 (27%)
		Ig5_KIRREL3-like	428..524	CDD:143235	25/96 (26%)
		IG_like	435..524	CDD:214653	23/88 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810