DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment DSCAM and Dscam4

DIOPT Version :9

Sequence 1:NP_001380.2 Gene:DSCAM / 1826 HGNCID:3039 Length:2012 Species:Homo sapiens
Sequence 2:NP_001261571.1 Gene:Dscam4 / 2769008 FlyBaseID:FBgn0263219 Length:1935 Species:Drosophila melanogaster


Alignment Length:1978 Identity:613/1978 - (30%)
Similarity:949/1978 - (47%) Gaps:230/1978 - (11%)


- Green bases have known domain annotations that are detailed below.


Human    19 DLHS------SLYFVNASLQEVV-------------------FASTTGTLVPCPAAGIPPVTLRW 58
            ||||      .||.:.|...:.|                   |::.:|.|:.|...|.||..:.|
  Fly     2 DLHSLFKAILILYVIRAETSQFVNGLDLQGPIFLHEPPHRVEFSNNSGGLIECSGHGSPPPEVEW 66

Human    59 YLATGEE--IYDVPGIRHVHPNGTLQIFPFPPSSFSTLIHDNTYYCTAENPSGKIRSQDVHIKAV 121
            .....::  ::.:       .||::..:||....:...:|...|.|...|..|.:.|::||::.|
  Fly    67 TPIPPQQDMVFQL-------SNGSMMFYPFTAEKYRHEVHATVYRCKLRNLVGTVLSREVHVRGV 124

Human   122 LREPYTVRVEDQKTMRGNVAVFKCIIPSSVEAYITVVSWEKDT-----VSLVSGSRFLITSTGAL 181
            :.:.|.|:|.|:..|.||.||.||.:||.:..::.|.:|.:||     .:...|.::.:.|.|.|
  Fly   125 VNQKYAVQVHDEYVMTGNTAVLKCQVPSYMSEFVLVTAWVQDTGMHLYPNTDIGGKYTVLSNGEL 189

Human   182 YIKDVQNEDGLYNYRCITRHRYTGETRQSN-SARLFVSDPANSAPSILDGFDH--RKAMAGQRVE 243
            ||.:....|...:|.|.|.:|.|||.:.|. ..|:.|::|.......::...|  |..:...:..
  Fly   190 YINNAGPNDAYKSYTCRTVNRLTGEVQISTYPGRIIVTEPKGMVQPRINVEKHSMRHVVLNGQTT 254

Human   244 LPCKALGHPEPDYRWLKDN----MPLELSGRFQKTVTGLL-IENIRPSDSGSYVCEVSNRYGTAK 303
            |||.|.|||.|.|||.|:.    :||:||.|......||| |...|..|||.|:|.|:|..|...
  Fly   255 LPCIAQGHPVPTYRWFKEENEQLLPLQLSERITIVSAGLLKITKARLEDSGKYLCWVNNTAGEET 319

Human   304 VIGRLYVKQPLKATISPRKVKSSVGSQVSLSCSVTGTEDQELSWYRNGEILNPGKNVRITGINHE 368
            :...|.|..||.|.:.|:.....|.......|.|:|....:::|..:|:.:.....|.|. .:..
  Fly   320 IQVSLTVTAPLTAHLQPQVQTVDVDKDAQFQCIVSGHPVHDVNWLHDGKPILRDNRVEIL-TDPP 383

Human   369 NLIMDHMVKSDGGAYQCFVRKDKLSAQDYVQVVLEDGTPKIISAFSEKVVSPAEPVSLMCNVKGT 433
            .||:..:.|.|.|.|||||..:....|...::.|.|.:|:::..|||:.:.|...|||.|...|.
  Fly   384 RLIIKKVQKEDPGMYQCFVSNEWEQIQSTAELQLGDASPELLYWFSEQTLQPGPTVSLKCVATGN 448

Human   434 PLPTITWTLDDDPILKGGSHRISQMITSEGNVVSYLNISSSQVRDGGVYRCTANNSAGVVLYQAR 498
            |||..||:||..||.......:.|.:|...:|:|::|||:.:..|||.|.|||.|:.|.|.:.|:
  Fly   449 PLPQFTWSLDGFPIPDSSRFLVGQYVTIHDDVISHVNISNVKEEDGGEYTCTAQNAIGKVSHSAK 513

Human   499 INVRGPASIRPMKNITAIAGRDTYIHCRVIGYPYYSIKWYKNSNLLPFNHRQVAFENNGTLKLSD 563
            :|:.|...||.|..||.|:|.|..:.|.|.|||...|.|.::...||.|.||.|: |||||.:..
  Fly   514 VNIYGLPYIREMPKITGISGSDLIVKCPVAGYPIDKIHWERDGQTLPINRRQRAY-NNGTLIIEQ 577

Human   564 VQKEVDEGEYTCNVLVQPQLSTSQSVHVTVKVPPFIQPFEFPRFSI--GQRVFIPCVVVSGDLPI 626
            :|:..|.|.|||....:.:.::.::|.:.|.|||.|.|.:.....:  |.|..|.|.::.||||:
  Fly   578 LQRLEDAGTYTCMAQNKQKQTSRRNVEIQVLVPPKIMPIQAMTNMLREGMRAAISCQILEGDLPV 642

Human   627 TITWQKDGRPIPGSLGVTIDNID-FTSSLRISNLSLMHNGNYTCIARNEAAAVEHQSQLIVRVPP 690
            :..|:::|:|:.|:.......:| :::||.|.::|..|:|||||||.|.|........|.|.|||
  Fly   643 SFRWERNGKPLIGTGNEVFRRLDEYSASLVIEHISSDHSGNYTCIASNVAGTERFTVPLTVNVPP 707

Human   691 KFVVQPRDQDGIYGKAVILNCSAEGYPVPTIVWKFSKGAGVPQFQPIALNGRIQVLSNGSLLIKH 755
            |::::|:|.....|..|:|:|.:.|||.|||.||.:.|....:::.......:|:..||::..|.
  Fly   708 KWILEPKDSSAQAGADVLLHCQSSGYPTPTITWKKAIGPTPGEYKDFLYEPTVQLFPNGTIFFKK 772

Human   756 VVEEDSGYYLCKVSNDVGADVSKSMYLTVKIPAMITSYPNTTLATQGQKKEMSCTAHGEKPIIVR 820
            :.:|..|::||:..|::|:.|||.::|.|.:||...:........:|::..:.|...|:.||..:
  Fly   773 ISKESQGHFLCEAKNNIGSGVSKVIFLKVNVPAHFQTKTKQISVAKGKQVHVQCNVQGDNPIDFK 837

Human   821 W--EKEDRIINPEM-ARYLVSTKEVGEEVISTLQILPTVREDSGFFSCHAINSYGEDRGIIQLTV 882
            |  :...:.::..: :||.:..:.:.:.::|.|.|..|.|:|:|.:.|.|.|::|:|...|||.|
  Fly   838 WKIQATQQYLDESLDSRYTIRDQVLDDGMVSELGISHTYRQDTGIYICQASNAFGQDEMSIQLIV 902

Human   883 QEPPDPPE-IEIKDVKARTITLRWTMGFDGNSPITGYDIECKNKSDSWDSAQRTKDVSPQLNSAT 946
            ||.|:.|: :.|...::|::.|.|:..|.|||||..|.|..|..||.|.:|:.......|    |
  Fly   903 QEVPEQPKNLRINSQQSRSLQLTWSQPFAGNSPIEEYHIYYKQISDIWQNAEHLTIAGAQ----T 963

Human   947 IIDI---HPSSTYSIRMYAKNRIGKSEPSNELTITADEAAPDGPPQEVHLEPISSQSIRVTWKAP 1008
            :|:|   .|:..|.|||.|:|::|.||.|..:.:|..|..|.|||..|..||.||..|.|||.||
  Fly   964 VINIQQLRPAKAYHIRMSAENKLGASEFSEVVQVTTLEEVPSGPPLAVRAEPKSSTEIFVTWDAP 1028

Human  1009 KKHLQNGIIRGYQIGY--------REYSTGGNFQFNIISVDTSGDSEVYTLDNLNKFTQYGLVVQ 1065
            ::...|||:.||.:||        :|.:....|.|..:.|.:....|. .|.||||||||.::||
  Fly  1029 ERDHWNGILLGYYVGYQMSLTPEDKEVNPTQGFSFKTVEVRSHFGGET-VLANLNKFTQYHVIVQ 1092

Human  1066 ACNRAGTGPSSQEIITTTLEDVPSYPPENVQAIATSPESISISWSTLSKEALNGILQGFRVIYWA 1130
            |....|:||.|:||...|:|||||.|||:.|.......||.|:||....:..||.::|::|.|  
  Fly  1093 AYTSQGSGPPSKEIAVQTMEDVPSSPPESPQCDVLGSTSIYITWSPPDIDGQNGKIKGYKVFY-- 1155

Human  1131 NLMDGELGEI--KNITTTQPSLELDGLEKYTNYSIQVLAFTRAGDGVRSEQIFTRTKEDVPGPPA 1193
             :...||.|.  :.:.:|...:.::.|.|||||::.|||:|:.|||::::..:.||.||||..|.
  Fly  1156 -ISVDELYETDPEVVKSTNQYVTIENLRKYTNYTVWVLAYTKVGDGMKTKPFYCRTHEDVPSAPQ 1219

Human  1194 GVKAAAASASMVFVSWLPPLKLNGIIRKYTVFCSHPYPTVISEFEASPDSFSYR----------- 1247
            .:||..||:|.:.:|||||...||.|..||.:        :|..|...:..:::           
  Fly  1220 AIKAIPASSSKIIISWLPPDLPNGDITGYTFY--------MSMLEGGREEGTHKRLLGPFVEMHE 1276

Human  1248 IPNLSRNRQYSVWVVAVTSAGRGNSSEIITVEPLAKAPARILTFSGTVTTPWMKDIVLPCKAVGD 1312
            ......:..|..|:.|.|..|.|..::::||.|..|.||||::||..:.|||.:.:.|||:.||.
  Fly  1277 TVRTQESATYQFWLTASTKMGEGEKTQVVTVPPNNKVPARIVSFSQRIVTPWKEHLELPCRKVGA 1341

Human  1313 PSPAVKWMKDSNGTPSLVTIDGRRSIFSNGSFIIRTVKAEDSGYYSCIANNNWGSDEIILNLQVQ 1377
            |:|...|.:|.:.    :....|::|..||:..::..:|.|:|.|:|...|.||.|||:.|:.|:
  Fly  1342 PAPVTIWRQDGHN----METSARKTIAKNGTLYMKECQASDAGNYTCSVENTWGKDEIVYNIVVK 1402

Human  1378 VPPDQPRLTVSKTTSSSITLSWLPGDNGGSSIRGYILQYSEDNSEQWGSFPISPSERSYRLENLK 1442
            |||:.|.|||....:.|:.|.|:...:|||.|.||::.|..||.: |....:.....|:.|.||.
  Fly  1403 VPPEAPNLTVINAYTDSLLLEWMDNSHGGSPILGYVINYKRDNGD-WEELQVDSKTTSHLLTNLW 1466

Human  1443 CGTWYKFTLTAQNGVGPGRISEIIEAKTLGKEPQFSKEQELFASINTTRVRLNLIGWNDGGCPIT 1507
            |||.|:..:||.|.:|.|...:|:.:.|.|..|...|..::..: |:|.|...|..|.||||.|.
  Fly  1467 CGTRYQLYITAYNKIGTGLPCDIVNSYTKGNPPVQPKHSQMITN-NSTSVTCWLDSWGDGGCGIL 1530

Human  1508 SFTLEYRPFGTTVWTTAQR--TSLSKSYILYDLQEATWYELQMRVCNSAGCAEKQANFATLNYDG 1570
            .|.:|.|.:|.:.|.....  ....:.|.:.||...|.|:|::...|:||......||.||:..|
  Fly  1531 YFMIESRVYGRSSWAVVSNHIPPTERIYTVSDLVPGTKYQLKVTAHNNAGSTTAIYNFTTLSTQG 1595

Human  1571 STIPPLIKSVVQNEEGLTTNEGL---------KMLVTISCILVGVLLLFVLLLVVRRRRREQRLK 1626
                     |:.|.:..|....|         |:|:.|...|:.:|.|....|.:|:|       
  Fly  1596 ---------VIYNNDHSTPVSHLSDLPFYANFKLLLPICFSLLMLLALIGAALFLRKR------- 1644

Human  1627 RLRDAKSLAEMLMSKNTRTSDTLSKQQQTLRMHIDIPRAQLLIEERDTMETIDDRSTVLLTDADF 1691
            :|.....||...||::...::..:||.          |.|..:..|....|...|.:.......|
  Fly  1645 KLASQARLASSSMSESPSLANLQNKQN----------RDQQYLAVRCNPGTSAPRGSNSNDSGSF 1699

Human  1692 GEAAKQKSLT-----VTHTVHYQSVSQA-------TGPLVDV------SDARPGTNPT-----TR 1733
            |:|...:.:.     .|..::.|:.|::       :||...|      .|.:|.:..:     |:
  Fly  1700 GKAEGNEYIEDICPYATFQLNKQTYSESSYSGNVYSGPYHSVRGSFVYHDVKPESYHSKEPEYTK 1764

Human  1734 RNAKAGPTARNRYASQWTLNRPHPTISAHTLTTDWRLPTPRAAGSVDKESDSYSVSPSQDTDRAR 1798
            ...|.|           .|..||                     |..:|||    :|.......|
  Fly  1765 VRRKVG-----------RLRDPH---------------------SESQESD----NPGSTDSEVR 1793

Human  1799 SSMV--------STESASSTYEELARAYEHAKMEEQLRHAKFTITECFISDTSSEQLTAGTNEYT 1855
            ..:.        .|..:.|..:..|||...||...|             .||..|         |
  Fly  1794 KILTLHIPITEYDTLGSESDNDVSARALNSAKYRAQ-------------RDTQDE---------T 1836

Human  1856 DSLTSSTPSESGICRFTASPPKPQDGGR 1883
            .|.:.:||  :.:.|.:..|...:.||:
  Fly  1837 SSSSETTP--TSMTRKSKPPFAARKGGK 1862

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
DSCAMNP_001380.2 Ig 45..113 CDD:319273 14/69 (20%)
I-set 235..310 CDD:254352 31/79 (39%)
I-set 315..385 CDD:333254 16/69 (23%)
Ig_3 407..488 CDD:316449 33/80 (41%)
IGc2 518..575 CDD:197706 24/56 (43%)
I-set 596..686 CDD:333254 32/92 (35%)
Ig_DSCAM 707..784 CDD:143211 26/76 (34%)
Ig 802..889 CDD:325142 27/89 (30%)
FN3 885..978 CDD:238020 34/96 (35%)
FN3 986..1083 CDD:238020 44/104 (42%)
FN3 1091..1184 CDD:238020 31/94 (33%)
FN3 1189..1278 CDD:238020 25/99 (25%)
Ig 1303..1369 CDD:319273 21/65 (32%)
FN3 1380..1470 CDD:238020 32/89 (36%)
FN3 1486..1555 CDD:238020 22/70 (31%)
Required for netrin-mediated axon repulsion of neuronal growth cones. /evidence=ECO:0000250|UniProtKB:Q9ERC8 1617..2012 56/298 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1718..1810 16/110 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1855..1883 7/27 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1971..2012
Dscam4NP_001261571.1 Ig 31..124 CDD:416386 20/99 (20%)
Ig strand A 32..35 CDD:409353 0/2 (0%)
Ig strand A' 41..45 CDD:409353 0/3 (0%)
Ig strand B 48..57 CDD:409353 3/8 (38%)
Ig strand D 75..78 CDD:409353 0/2 (0%)
Ig strand E 83..88 CDD:409353 0/4 (0%)
Ig strand F 101..109 CDD:409353 2/7 (29%)
Ig strand G 112..124 CDD:409353 4/11 (36%)
Ig 235..326 CDD:416386 33/90 (37%)
Ig strand A 235..238 CDD:409353 0/2 (0%)
Ig strand A' 244..248 CDD:409353 1/3 (33%)
Ig strand B 251..258 CDD:409353 2/6 (33%)
Ig strand C 266..271 CDD:409353 3/4 (75%)
Ig strand C' 276..279 CDD:409353 0/2 (0%)
Ig strand D 285..289 CDD:409353 1/3 (33%)
Ig strand E 292..298 CDD:409353 4/5 (80%)
Ig strand F 305..313 CDD:409353 4/7 (57%)
Ig strand G 316..326 CDD:409353 2/9 (22%)
IgC2_3_Dscam 329..417 CDD:409549 23/88 (26%)
Ig strand B 347..351 CDD:409549 0/3 (0%)
Ig strand C 360..364 CDD:409549 0/3 (0%)
Ig strand E 383..387 CDD:409549 1/3 (33%)
Ig strand F 397..402 CDD:409549 3/4 (75%)
Ig strand G 410..413 CDD:409549 1/2 (50%)
IgI_4_Dscam 422..516 CDD:409548 37/93 (40%)
Ig strand B 439..443 CDD:409548 3/3 (100%)
Ig strand C 452..456 CDD:409548 1/3 (33%)
Ig strand E 482..486 CDD:409548 1/3 (33%)
Ig strand F 496..501 CDD:409548 2/4 (50%)
Ig strand G 509..512 CDD:409548 0/2 (0%)
IgI_5_Dscam 520..607 CDD:409550 33/87 (38%)
Ig strand B 536..540 CDD:409550 0/3 (0%)
Ig strand C 549..553 CDD:409550 1/3 (33%)
Ig strand E 571..575 CDD:409550 3/3 (100%)
Ig strand F 586..591 CDD:409550 3/4 (75%)
Ig strand G 600..603 CDD:409550 0/2 (0%)
Ig 610..703 CDD:416386 32/92 (35%)
Ig strand A 611..613 CDD:409353 1/1 (100%)
Ig strand A' 620..624 CDD:409353 0/3 (0%)
Ig strand B 627..636 CDD:409353 3/8 (38%)
Ig strand C 641..648 CDD:409353 2/6 (33%)
Ig strand C' 650..652 CDD:409353 1/1 (100%)
Ig strand D 659..664 CDD:409353 0/4 (0%)
Ig strand E 668..675 CDD:409353 3/6 (50%)
Ig strand F 682..690 CDD:409353 7/7 (100%)
Ig strand G 693..702 CDD:409353 0/8 (0%)
IgI_7_Dscam 706..801 CDD:409546 32/94 (34%)
Ig strand B 724..728 CDD:409546 2/3 (67%)
Ig strand C 737..741 CDD:409546 2/3 (67%)
Ig strand E 766..770 CDD:409546 1/3 (33%)
Ig strand F 780..785 CDD:409546 2/4 (50%)
Ig strand G 794..797 CDD:409546 2/2 (100%)
Ig 818..904 CDD:416386 24/85 (28%)
putative Ig strand B 820..827 CDD:409353 0/6 (0%)
putative Ig strand C 835..841 CDD:409353 1/5 (20%)
putative Ig strand C' 853..856 CDD:409353 1/2 (50%)
putative Ig strand D 862..866 CDD:409353 0/3 (0%)
putative Ig strand E 868..874 CDD:409353 3/5 (60%)
putative Ig strand F 881..889 CDD:409353 3/7 (43%)
putative Ig strand G 892..902 CDD:409353 5/9 (56%)
FN3 906..999 CDD:238020 34/96 (35%)
FN3 1006..1110 CDD:238020 44/104 (42%)
fn3 1117..1203 CDD:394996 31/88 (35%)
FN3 1215..1307 CDD:238020 25/99 (25%)
Ig <1334..1401 CDD:416386 25/70 (36%)
Ig strand C 1345..1349 CDD:409353 0/3 (0%)
Ig strand D 1363..1366 CDD:409353 1/2 (50%)
Ig strand E 1367..1372 CDD:409353 1/4 (25%)
Ig strand F 1380..1388 CDD:409353 3/7 (43%)
Ig strand G 1394..1401 CDD:409353 3/6 (50%)
FN3 1405..1494 CDD:238020 32/89 (36%)
FN3 1499..1580 CDD:238020 24/81 (30%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 137 1.000 Domainoid score I4888
eggNOG 1 0.900 - - E1_KOG3510
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H74393
Inparanoid 1 1.050 968 1.000 Inparanoid score I322
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG47134
OrthoDB 1 1.010 - - D10185at33208
OrthoFinder 1 1.000 - - FOG0003568
OrthoInspector 1 1.000 - - mtm8541
orthoMCL 1 0.900 - - OOG6_101656
Panther 1 1.100 - - O PTHR10075
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4969
SonicParanoid 1 1.000 - - X1391
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1514.870

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