Protein Alignment DSCAM and zig-4

DIOPT Version :10

• Sequence 1: NP_001380.2
• Gene: DSCAM / 1826
• HGNCID: 3039
• Length: 2012
• Species: Homo sapiens
• Sequence 2: NP_509335.1
• Gene: zig-4 / 181051
• WormBaseID: WBGene00006981
• Length: 253
• Species: Caenorhabditis elegans
• Alignment Length: 238
• Identity: 54/238 - (22%)
• Similarity: 93/238 - (39%)
• Gaps: 46/238 - (19%)

Human   572 EYTCNVLVQPQLSTSQSVHVTVKVPPFIQPFEFPRFSIGQRVFIPCVVVSGDLPITITWQKDGRP 636
            |...|.|..|         ..:|:   :.|.|......|:...:.|.::|.. ..||.|:.:|:.
 Worm    34 EIDTNYLTSP---------AKIKI---VAPLESALIPGGETYQLRCDIMSTP-AATIHWKFNGKL 85

Human   637 IPGSLGVTIDN--IDF----------TSSLRISNLSLMHNGNYTCIARNEAAAVEHQSQLIV--- 686
            |.||..:.::.  ::|          .|.|.|...|..::|.|:|:..|....:|..:::.:
 Worm    86 IQGSNELNVEEKLLNFGKAIVDTGIVASILTIQCPSAENSGTYSCVGYNGHQTIETVAEVEIEGE 150

Human   687 --------RVPPKFVVQPRDQDGIYGKAVILNCSAEGYPVPTIVWKFSKGAGVPQFQPIALNGRI 743
                    :..|:.|.....:..:.|....|.|.|.    ..:.|.:     :...:.:..|.:.
 Worm   151 ASGCRSNHKSAPEIVFWTDSRFEMTGNVATLVCRAN----QQVDWVW-----MSNDELVKNNDKF 206

Human   744 QVLSNGSLLIKHVVEEDSGYYLCKVSNDVG-ADVSKSMYLTVK 785
            .|||||.|:||::|.:|.|.|.|...|..| |.....:|.|.|
 Worm   207 TVLSNGDLVIKNIVWDDMGTYTCIARNQFGEARQETFLYPTAK 249

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DSCAM	NP_001380.2	FN3	885..978	CDD:238020
		FN3	<937..1300	CDD:442628
		Ig_3	1287..1363	CDD:464046
		FN3	1380..1470	CDD:238020
		FN3	1486..1555	CDD:238020
		Required for netrin-mediated axon repulsion of neuronal growth cones. /evidence=ECO:0000250|UniProtKB:Q9ERC8	1617..2012
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1718..1810
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1855..1883
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1971..2012
		Ig	26..121	CDD:472250
		Ig strand B	42..46	CDD:409353
		Ig strand C	55..59	CDD:409353
		Ig strand E	79..83	CDD:409353
		Ig strand F	99..104	CDD:409353
		Ig strand G	112..116	CDD:409353
		Ig	125..210	CDD:472250
		Ig strand B	141..145	CDD:409353
		Ig strand C	157..161	CDD:409353
		Ig strand E	179..183	CDD:409353
		Ig strand F	192..199	CDD:409353
		I-set	235..310	CDD:400151
		Ig strand B	242..246	CDD:409353
		Ig strand C	255..259	CDD:409353
		Ig strand F	290..295	CDD:409353
		Ig	313..395	CDD:472250
		Ig strand B	331..335	CDD:409353
		Ig strand C	344..348	CDD:409353
		Ig strand E	368..372	CDD:409353
		Ig strand F	382..387	CDD:409353
		Ig	406..501	CDD:472250
		Ig strand B	424..428	CDD:409353
		Ig strand C	437..441	CDD:409353
		Ig strand E	467..471	CDD:409353
		Ig strand F	481..486	CDD:409353
		Ig strand G	494..497	CDD:409353
		IgI_5_Dscam	504..593	CDD:409550	4/20 (20%)
		Ig strand A	505..507	CDD:409550
		Ig strand A'	512..516	CDD:409550
		Ig strand B	519..526	CDD:409550
		Ig strand C	533..539	CDD:409550
		Ig strand C'	540..542	CDD:409550
		Ig strand D	549..553	CDD:409550
		Ig strand E	557..563	CDD:409550
		Ig strand F	571..579	CDD:409550	2/6 (33%)
		Ig strand G	583..593	CDD:409550	0/9 (0%)
		Ig	596..686	CDD:472250	22/101 (22%)
		Ig strand B	613..617	CDD:409353	0/3 (0%)
		Ig strand C	627..631	CDD:409353	2/3 (67%)
		Ig strand E	652..656	CDD:409353	2/3 (67%)
		Ig strand F	666..671	CDD:409353	2/4 (50%)
		Ig strand G	679..682	CDD:409353	1/2 (50%)
		Ig_DSCAM	689..784	CDD:409397	25/95 (26%)
		putative Ig strand A	689..693	CDD:409397	1/3 (33%)
		putative Ig strand A'	698..702	CDD:409397	0/3 (0%)
		putative Ig strand B	704..714	CDD:409397	3/9 (33%)
		putative Ig strand C	720..726	CDD:409397	1/5 (20%)
		putative Ig strand C'	733..736	CDD:409397	0/2 (0%)
		putative Ig strand D	744..747	CDD:409397	1/2 (50%)
		putative Ig strand E	749..755	CDD:409397	3/5 (60%)
		putative Ig strand F	762..770	CDD:409397	3/7 (43%)
		putative Ig strand G	775..784	CDD:409397	1/8 (13%)
		Ig_DSCAM	785..884	CDD:409398	1/1 (100%)
		putative Ig strand A	785..788	CDD:409398	1/1 (100%)
		putative Ig strand A'	796..800	CDD:409398
putative Ig strand B	803..810	CDD:409398
putative Ig strand C	818..824	CDD:409398
putative Ig strand C'	833..836	CDD:409398
putative Ig strand D	842..846	CDD:409398
putative Ig strand E	848..854	CDD:409398
putative Ig strand F	861..869	CDD:409398
putative Ig strand G	872..882	CDD:409398
zig-4	NP_509335.1	Ig_3	47..134	CDD:464046	21/90 (23%)
		IG_like	176..245	CDD:214653	22/77 (29%)
		Ig strand B	179..183	CDD:409353	1/3 (33%)
		Ig strand C	190..194	CDD:409353	1/8 (13%)
		Ig strand E	212..216	CDD:409353	2/3 (67%)
		Ig strand F	226..231	CDD:409353	2/4 (50%)
		Ig strand G	240..243	CDD:409353	0/2 (0%)