DRSC/TRiP Functional Genomics Resources

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Protein Alignment DSCAM and C27B7.7

DIOPT Version :10

Sequence 1:NP_001380.2 Gene:DSCAM / 1826 HGNCID:3039 Length:2012 Species:Homo sapiens
Sequence 2:NP_001255352.1 Gene:C27B7.7 / 177708 WormBaseID:WBGene00007764 Length:1456 Species:Caenorhabditis elegans


Alignment Length:1365 Identity:271/1365 - (19%)
Similarity:447/1365 - (32%) Gaps:473/1365 - (34%)


- Green bases have known domain annotations that are detailed below.


Human   319 SPRKVKSSVGSQVSLSCSV------TGTEDQELSWYRNGEILNPGKNVRITGINHENLIMDHMVK 377
            ||..:.:|:.:.::|...|      ||:......:|.|..          :..|.|         
 Worm    27 SPLFISTSIDNSMNLKILVEKKPYFTGSVTGYKLYYTNDS----------SQTNEE--------- 72

Human   378 SDGGAYQCFVRKDKLSAQDYVQVVLEDGTPKIIS---------AFSEKVVS-PAEPVSLMCNVKG 432
                 |:.::.::.||.|:....|::....:|:|         .|...|.| |...:|:......
 Worm    73 -----YEKWMHQEALSNQNSYNFVIDANKHEIVSGDVYRVRATVFFNNVESVPTGVISINTRQSI 132

Human   433 TPLPTITWTLDDDPILKGGSHRISQMITSEGNVVSYLNISSSQVR-------------DGGVYRC 484
            ...|.|..|    .||...|..||.:...:.|.:....:...|:.             ||.|.  
 Worm   133 PKAPLIVNT----KILYNSSVLISFVPADDVNAIENYTLMYKQMEAEEWKSLNFKSDFDGKVL-- 191

Human   485 TANNSAGVV---LYQARINVRGPASIRPMKNITAIAGRDTYIHCRVIGYPYYSIKWYKNSNLLPF 546
                ..|::   .|:.:|.|.|..                     |.|.|         |||..|
 Worm   192 ----LDGLIPNHTYEIKIFVTGGI---------------------VQGTP---------SNLATF 222

Human   547 NHRQVAFENNGTLKLSDVQKEVDEGEYTCNVLVQPQLSTSQSVHVTVKVPPFIQPFEFPRFSIGQ 611
            .....|        |:.|:.|.|| |||.:    ||.:...|:..|||             |:.:
 Worm   223 TTNSTA--------LALVKTEPDE-EYTAD----PQTNEPLSITCTVK-------------SVSK 261

Human   612 RVFIPCVVVSGDLPITITWQKDGRPIPGSLGVTIDNIDFT-----------SSLRISNLSLMHNG 665
                          .::.|:.:|      :.|::|:..:|           |::|..  |...:.
 Worm   262 --------------ASVLWKVNG------IKVSVDSSFYTVVTSVHEDFIESTIRAK--SRTRSA 304

Human   666 NYTCIARNEAAAVEHQSQLIVRVPPKFVVQPRDQDGIYGKAVILNCSAEGYPVPTIVWKFSKGAG 730
            .:||:|.|:|.....:..:|::.|           |.....:.|.....||   ||.||      
 Worm   305 KFTCLATNDAGDSSKEVNVIIKGP-----------GSPPSEITLVAEKRGY---TISWK------ 349

Human   731 VPQFQPIALNGRIQV--------------------LSNGSLLIKHVVE-EDSGYYLCKVSNDVGA 774
             |...|   ||:|..                    |.....:::.::: |:|.|...:.:.::|.
 Worm   350 -PPSHP---NGKITKYVVYHTLNREDPLSDWRKIDLDGSEKMVRIIMDTEESFYGRVQAATELGP 410

Human   775 DV---------------SKSMYLTVKIPAMITSYPNTTLATQGQKKEMSCTAHGEKP-----IIV 819
            .:               .:|....|....|:.: |..||:.|       |||.| ||     :.:
 Worm   411 GIISDIVAMERDTQPISVESDLFGVSATTMVVN-PRETLSIQ-------CTARG-KPRPSISVAI 466

Human   820 RWEKEDRIINPEMARYLVSTKEVGEEVISTLQILPTVREDSGFFSCHAINSYGEDRGIIQLTVQE 884
            ...|....:..::...|.:|...|  ::|.:.....:  .|.|..|.|.||.|.:...::|.|.:
 Worm   467 SDRKNASQVEVDVWSRLQATSSAG--IVSAVHNFSVL--TSKFVHCRAKNSAGSNYSTMELKVDK 527

Human   885 PPD-PPEIEIKDVKARTITLRWTMGFDGNSPITGYDIECKNKSDSWDSAQRTKDVSPQLNSATII 948
            |.| |.:|::..|.|....:.|......|||||.|.:...| .|..|.:                
 Worm   528 PGDAPTQIQVLSVNALDALVVWHSPQFPNSPITSYIVLVSN-DDKEDKS---------------- 575

Human   949 DIHPSSTYSIRMYAKNRIGKSEPSNELTITADEAAPDGPPQEVHLEPISSQSIRVTWKAPKKHLQ 1013
                                                                   ||      ||
 Worm   576 -------------------------------------------------------TW------LQ 579

Human  1014 NGIIRGYQIGYREYSTGGNFQFNIISVDTSGDSEVYTLDNLNKFTQYGLVVQACNRAGTGPSSQE 1078
                  |:...:|      .|.|.:.:.|.         ||.|.|:|.:.|:|.|.||.||:|..
 Worm   580 ------YESNAKE------TQINRMLLPTG---------NLEKSTEYFVCVRAKNAAGIGPTSSL 623

Human  1079 IITTTLEDVPSYPPENVQAIATSPESISISWSTLSKEALNGILQGFRVIYWANL-------MDGE 1136
            |...||...|..||:|::.:......:.:.|:|.:...   .:.|:.:.|..:|       .:.:
 Worm   624 ISFITLNGGPDSPPDNLKVLINEANQVIVYWNTPNSTT---EVTGYLIYYTRDLSLSNDDYKNWQ 685

Human  1137 LGEIKNITTTQPSLELD-GLEKYTNYSIQVLAFTRAGDGVRSEQI-FTRTKEDVPGPPAGVKAAA 1199
            ..|:.| .:|:...:|. ||:..|.|.:::.......||..||.: |.....:|| .|..:|...
 Worm   686 FVEMNN-NSTRYKFDLSVGLKPKTFYRVRISGKNSHADGPASEVVEFETAYSEVP-IPTDLKTEV 748

Human  1200 ASASMVFVSWLPPLKLNGI---------IRKYTVFCS-------------HPYPTVISEF----- 1237
            ...:.:.:      |.|.:         :.:|.:..:             .|....|.|.     
 Worm   749 LDDNTIHI------KFNAVRDPDDHSKALGEYRIDLAATDDVLHALWKQIEPKSIKIDEISSMVD 807

Human  1238 -EASPDSFSYRIPNLSRNRQYSVWVVAVTS---------------AGRGNSSEIITVE--PLAKA 1284
             |...||       :.:|:.|.|.|.|...               .|.|.....:|:|  ||.:.
 Worm   808 VEIDGDS-------VEKNQMYWVKVTARLDNPSWGMHSSKPRWFRTGHGKLMTSVTLEGAPLIEK 865

Human  1285 PARILTFSGTVTTPWMKDIVLPCKAVGDPSPAV--KWMKDS--NGTPSL----VTIDGRRSIFSN 1341
            ...:           .:::.:.|..:|.|:|.:  :||..|  |||...    :.||....:   
 Worm   866 EPNL-----------FEELSVTCTGMGSPAPIITWEWMNKSIENGTEGWNILNIQIDDTTVV--- 916

Human  1342 GSFIIRTVKAEDSGYYSCIANNNWGSDEIILNLQVQVPPDQPRLTVSKTTSSSITLSWLPGDNGG 1406
             |.|.|. ...:||..:|:||||.||....:.::|..|.:.|...:.....:.|.::|.......
 Worm   917 -SKITRN-NIRESGDLTCLANNNEGSSSASVEIRVLGPGNPPENIILTAYRNQINVTWQESTLPN 979

Human  1407 SSIRGYILQYSE---DNSEQWGSFPISPSERSYRLENLKCGTWYKFTLTAQNGVGPGRISEI--- 1465
            ..|..||:.|||   |:...|..|..:..| :| :|.....|.:...:.|.:..|||.||.:   
 Worm   980 GDIMKYIVYYSENENDDLSDWNKFETAELE-TY-VETFGPHTKHFIRVQAVSDRGPGIISNVLSC 1042

Human  1466 ------------------------------IEAKTLGK-EP----QFSKEQEL-FASINTTRVRL 1494
                                          |..|..|| :|    ||:.|.|. |..:.|..:.|
 Worm  1043 ISDVLYETIHLEIVASNILDFEAEPNQNVEIRCKGTGKPQPELFYQFANETEQNFVEVETNDMDL 1107

Human  1495  1494
             Worm  1108  1107

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
DSCAMNP_001380.2 FN3 885..978 CDD:238020 16/93 (17%)
FN3 <937..1300 CDD:442628 71/416 (17%)
Ig_3 1287..1363 CDD:464046 19/83 (23%)
FN3 1380..1470 CDD:238020 23/125 (18%)
FN3 1486..1555 CDD:238020 2/9 (22%)
Required for netrin-mediated axon repulsion of neuronal growth cones. /evidence=ECO:0000250|UniProtKB:Q9ERC8 1617..2012
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1718..1810
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1855..1883
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1971..2012
Ig 26..121 CDD:472250
Ig strand B 42..46 CDD:409353
Ig strand C 55..59 CDD:409353
Ig strand E 79..83 CDD:409353
Ig strand F 99..104 CDD:409353
Ig strand G 112..116 CDD:409353
Ig 125..210 CDD:472250
Ig strand B 141..145 CDD:409353
Ig strand C 157..161 CDD:409353
Ig strand E 179..183 CDD:409353
Ig strand F 192..199 CDD:409353
I-set 235..310 CDD:400151
Ig strand B 242..246 CDD:409353
Ig strand C 255..259 CDD:409353
Ig strand F 290..295 CDD:409353
Ig 313..395 CDD:472250 14/81 (17%)
Ig strand B 331..335 CDD:409353 1/3 (33%)
Ig strand C 344..348 CDD:409353 0/3 (0%)
Ig strand E 368..372 CDD:409353 1/3 (33%)
Ig strand F 382..387 CDD:409353 1/4 (25%)
Ig 406..501 CDD:472250 23/120 (19%)
Ig strand B 424..428 CDD:409353 1/3 (33%)
Ig strand C 437..441 CDD:409353 1/3 (33%)
Ig strand E 467..471 CDD:409353 0/3 (0%)
Ig strand F 481..486 CDD:409353 1/4 (25%)
Ig strand G 494..497 CDD:409353 1/2 (50%)
IgI_5_Dscam 504..593 CDD:409550 19/88 (22%)
Ig strand A 505..507 CDD:409550 0/1 (0%)
Ig strand A' 512..516 CDD:409550 0/3 (0%)
Ig strand B 519..526 CDD:409550 0/6 (0%)
Ig strand C 533..539 CDD:409550 0/5 (0%)
Ig strand C' 540..542 CDD:409550 0/1 (0%)
Ig strand D 549..553 CDD:409550 0/3 (0%)
Ig strand E 557..563 CDD:409550 1/5 (20%)
Ig strand F 571..579 CDD:409550 3/7 (43%)
Ig strand G 583..593 CDD:409550 1/9 (11%)
Ig 596..686 CDD:472250 14/100 (14%)
Ig strand B 613..617 CDD:409353 0/3 (0%)
Ig strand C 627..631 CDD:409353 0/3 (0%)
Ig strand E 652..656 CDD:409353 1/3 (33%)
Ig strand F 666..671 CDD:409353 2/4 (50%)
Ig strand G 679..682 CDD:409353 0/2 (0%)
Ig_DSCAM 689..784 CDD:409397 20/130 (15%)
putative Ig strand A 689..693 CDD:409397 1/3 (33%)
putative Ig strand A' 698..702 CDD:409397 0/3 (0%)
putative Ig strand B 704..714 CDD:409397 1/9 (11%)
putative Ig strand C 720..726 CDD:409397 4/5 (80%)
putative Ig strand C' 733..736 CDD:409397 0/2 (0%)
putative Ig strand D 744..747 CDD:409397 0/22 (0%)
putative Ig strand E 749..755 CDD:409397 0/5 (0%)
putative Ig strand F 762..770 CDD:409397 1/7 (14%)
putative Ig strand G 775..784 CDD:409397 1/23 (4%)
Ig_DSCAM 785..884 CDD:409398 25/103 (24%)
putative Ig strand A 785..788 CDD:409398 0/2 (0%)
putative Ig strand A' 796..800 CDD:409398 2/3 (67%)
putative Ig strand B 803..810 CDD:409398 0/6 (0%)
putative Ig strand C 818..824 CDD:409398 0/5 (0%)
putative Ig strand C' 833..836 CDD:409398 0/2 (0%)
putative Ig strand D 842..846 CDD:409398 1/3 (33%)
putative Ig strand E 848..854 CDD:409398 1/5 (20%)
putative Ig strand F 861..869 CDD:409398 3/7 (43%)
putative Ig strand G 872..882 CDD:409398 2/9 (22%)
C27B7.7NP_001255352.1 FN3 <54..364 CDD:442628 85/445 (19%)
FN3 133..224 CDD:238020 25/130 (19%)
fn3 330..414 CDD:394996 17/96 (18%)
Ig 436..>463 CDD:472250 11/35 (31%)
Ig strand B 448..452 CDD:409353 2/10 (20%)
FN3 530..628 CDD:238020 38/196 (19%)
FN3 635..733 CDD:238020 21/101 (21%)
Ig 868..949 CDD:472250 24/96 (25%)
Ig strand B 873..877 CDD:409353 0/3 (0%)
Ig strand C 886..890 CDD:409353 0/3 (0%)
Ig strand E 911..915 CDD:409353 1/3 (33%)
Ig strand F 929..934 CDD:409353 1/4 (25%)
Ig strand G 942..945 CDD:409353 0/2 (0%)
FN3 954..1043 CDD:238020 22/90 (24%)
FN3 1249..1337 CDD:238020
Blue background indicates that the domain is not in the aligned region.

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