DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment DSCAM and rig-4

DIOPT Version :10

Sequence 1:NP_001380.2 Gene:DSCAM / 1826 HGNCID:3039 Length:2012 Species:Homo sapiens
Sequence 2:NP_501339.2 Gene:rig-4 / 177597 WormBaseID:WBGene00004371 Length:2325 Species:Caenorhabditis elegans


Alignment Length:2235 Identity:460/2235 - (20%)
Similarity:761/2235 - (34%) Gaps:690/2235 - (30%)


- Green bases have known domain annotations that are detailed below.


Human   130 VEDQKTMRGNVAVFKCIIPSSVEAYITVVSWEKDTVS--LVSGSRFLITSTGALYIKDVQNEDGL 192
            ||.:..:.|.:...||......|.|    .|.....|  |::.|:|  ....|..:.|.:     
 Worm    37 VEQKVAVEGEIIRLKCDDAELAEQY----EWRIGDASGELIATSKF--CEVQASRVNDEK----- 90

Human   193 YNYRCITRHRYTGETRQSNSARLFVSDPANSAPSILDGFD--------------------HRKAM 237
             .|||:.|          |:....:|.|:......||.||                    .|..:
 Worm    91 -KYRCVAR----------NTVGAAISPPSMVRSKYLDDFDASDESVQYEVTTGVGRYFVLRRPTL 144

Human   238 AGQRVELPCKALGHPEPDYRWLKD--NMPLELSGRFQKTVTGLLIENIRPSDSGSYVCEVSNRYG 300
            ...|         :.:..|.|:||  :.....:..|..:...|::..::..|.|:|....|:. .
 Worm   145 LASR---------NLDISYSWIKDDSHQVTPDATHFVTSDGNLVVTGVKRDDFGAYKLMASSD-D 199

Human   301 TAKVIGRLY------VKQPLKATIS----PRK---VKSSVGSQVSLSC--SVTGTEDQELSWYRN 350
            ..:::.:.|      :...|:.|:|    |..   ::|::.......|  |....:|..:.|:.|
 Worm   200 LKEIVSKEYNVRDNGLSPSLQNTLSIVYFPTDRTIIESTLPHDEIFDCVTSFGSKDDVRIRWFLN 264

Human   351 GEILNPGKNVRITGINHENLIMDHMVKSDGGAYQCFVRKD---------KLSAQDYV-QVVLEDG 405
            |:.::..:....|.:|:..||:.:......|.::...|.|         |.:...:: :.:|:|.
 Worm   265 GQQISGSEVGMTTTLNNRRLIISNPSSFTRGEHKLECRADAAMGRTSDQKSAYMTFISRPILKDL 329

Human   406 TPKIISAFSEKVVSPAEPVSLMCNVKGTPLPTITWTLDDDPILKGGSHRISQMITSEGNVVSYLN 470
            ..:|     :|.|..:  :||.|:||......|.|       .|.|    ..|.|..|.    |.
 Worm   330 PNEI-----QKTVGSS--LSLKCSVKKKSSMDIKW-------YKNG----LMMTTQRGK----LT 372

Human   471 ISSSQVRDGGVYRCTANNSAGVVLYQARINVRGPASIRPMKNITAIAGRDTYIHCRVIGYPYYSI 535
            |...:..|.|:|:|.|.|:||..|          ||:                            
 Worm   373 IDRIKQDDFGLYQCEATNAAGADL----------ASV---------------------------- 399

Human   536 KWYKNSNLLPFNHRQVAFENNGTLKLSDVQKEVDEGEYTCNVLVQPQLS---TSQSVHVTVKVPP 597
             |.|                              |||  .|..|..::|   .|....::::.||
 Worm   400 -WVK------------------------------EGE--ANETVATEMSEDGMSLEEEISMETPP 431

Human   598 FIQPFEFPRF--SIGQRVFIPCVVVSGDLPITITWQKDGRPIPGSLGVTIDNIDFTSSLRISNLS 660
               |.:...|  |..|....|                                 |||.|      
 Worm   432 ---PRKLKFFDNSKSQEQLFP---------------------------------FTSEL------ 454

Human   661 LMHNGNYTCIARNEAAAVEHQSQLIVRVPPKFVVQPRDQDGIYGKAVILNCSAEGYPVPTIVWKF 725
                               ..||.:::.|....|.....      .:::.|:|.|.|.|.|:|  
 Worm   455 -------------------EPSQKLIKTPKDLTVASGTD------RIMMECAATGSPPPNIIW-- 492

Human   726 SKGAGVPQFQPIALNG-RIQV------LSNGSLLIKHVVEEDSGYYLCKVSNDVGADVSKSMYLT 783
                        .||| .||.      |:|..|.|..:.:.|.|.|.|::|   |::|..:..:.
 Worm   493 ------------LLNGHEIQTDNVKYDLTNDGLAIHDIRKSDEGEYTCEIS---GSNVKATANVQ 542

Human   784 VKIPAMITSYPNTTLATQGQKKEMSCTAHGE--KPIIVRWEKEDRII----NPEMARYLVSTKEV 842
            |...::|...|....:..|...|.||....|  :...|.|...|.::    |..:.   :|....
 Worm   543 VNGDSLIEYGPADQKSLIGTNVEFSCEVAKEYVRKASVEWYLNDVLLPVNGNSGLR---ISRNRK 604

Human   843 GEEVISTLQILPTVREDSGFFSCHAINSYGEDRGIIQLTVQEPPDPPEIEIKDVKART----ITL 903
            |..:|.  |:.|   :::|.:.|.......|:.....|.:.|.|..||....::...|    :.:
 Worm   605 GSLIIR--QVGP---DNTGEYRCRVTVDGREENASAMLQIIEKPAMPERVRAELHNETMPAKVRV 664

Human   904 RWTMGFDGNSPITGYDIECKNKSDS--WDSAQRTKDVSPQLNS-----ATIIDIHPSSTYSIRMY 961
            ||..|||||.||..:.||.:....:  |.......|..|:...     ..|.|:.||||...|:.
 Worm   665 RWNEGFDGNEPIIKHAIEMRTMGPTGLWSDWTTAIDNIPKEEGKPCCWTDIEDLRPSSTAEFRVV 729

Human   962 AKNRIGKSEPS-NELTITADEAAPDGPPQEVHLEPISSQSIRVTWKAPKKHLQNGIIRGYQIGYR 1025
            |.|:.|..:|| ...::|..:..|...|:.|.....|..|:.|.|:.||:.|.:|.:.||.:.||
 Worm   730 ASNKHGPGKPSLPSYSVTMPQQPPSAAPRNVAASARSPHSVMVQWQQPKEELDSGDVLGYVVRYR 794

Human  1026 --EYSTGGNFQFNIISVDTSGDSEVYTLDNLNKFTQYGLVVQACNRAGTGPSSQEIITTTLEDVP 1088
              .||:....:.|:    |:.|:....:|.|..:.:|.:.|.|.|:.|.|..|:.|..||.|..|
 Worm   795 LAGYSSLTWNEKNL----TTKDARNTLVDELITWREYEIQVAAYNKRGLGVFSESIEVTTSEGRP 855

Human  1089 SYPPENVQAIATSPESISISWSTLSKEALNGILQGFRVIYWANLMDGELGEI----------KNI 1143
            :..|:||:....:..:::|.::...::.:.|:..|::|.:|..  :.|.||:          :.:
 Worm   856 TQAPKNVRVKVLNSTAVAIEFTAPEQQRIPGVNLGYKVQFWKG--EPEKGELYKQVILDPDRRQL 918

Human  1144 TTTQPSLELDGLEKYTNYSIQVLAFTRAGDGVRSEQIFTRTKEDVPGPPAGVKAAAASASMVFVS 1208
            ||.     ::.|||:.:|::..|.||..|||.||..:...|:||.|.....:..|....:...::
 Worm   919 TTV-----VNELEKFGHYNLTTLCFTTPGDGPRSNVVKVVTEEDTPESVDELSIAEVMYNGAVIT 978

Human  1209 WLPPLKLNGIIRKYTV-FCSHPYPTVISEFEASPDSFSYRIPNLSRNRQYSVWVVAVTSAGRGNS 1272
            |..|||.|||:.|||: ..:...|.|.::.|....:.::.|..|..:.:|.|.|:|.|..|.|..
 Worm   979 WNSPLKQNGIVTKYTIRHWAASSPDVKTKHEVDGSTTNFTIDGLQPSTRYGVDVMASTRKGDGPV 1043

Human  1273 SEI---ITVEP-LAKAPARILTFSGTVTTPWMKDIVLPCKAVGDPSPAVK-W-----MKDSN--- 1324
            .|.   ..|.| |...|:.:.....:.||     :.|......|...|:: |     |.||:   
 Worm  1044 EETKFESGVPPELPGRPSMLSIGDISATT-----VQLHFTPGFDGHTAIRQWVVEGKMADSSVFA 1103

Human  1325 -----GTPSL--VTIDGRRSIFSNGSFII------RTVKAEDSGYYSCIANNNWGSDEIILNLQV 1376
                 ..|..  :|:.|.|........:|      |...:|.|..:..:..|             
 Worm  1104 HVFNVSAPKARSITVTGLRPFTQYQLRLIAENVKGRGAPSEPSRSFETLQTN------------- 1155

Human  1377 QVPPDQP--RLTVSKTTSSSITLSWLP--GDNGGSSIRGYILQYSEDNSEQWGSFPISPSERS-- 1435
               ||.|  ||.....:::||::||.|  ..:.....:||::.|.|.:.|.|.... :|:.||  
 Worm  1156 ---PDTPSQRLFAEPVSATSISVSWTPLLATHWNGQPKGYLIVYREIDDENWKEVR-TPALRSSE 1216

Human  1436 YRLENLKCGTWYKFTLTAQNGVGPGRISEIIEAKTLGKEPQFSKEQELFASINTTRVRLNLIGWN 1500
            :.:.:|:..|.|:..:.::||.|....::.::|:|....|..|....:   :.....:..:|.||
 Worm  1217 HTVTDLRPFTSYEVNVFSENGFGRSLPTDSVKARTYESVPSGSPRNIV---VTAEGSKAAIIKWN 1278

Human  1501 DGGCPITSFTLEYRPFGTTVWTTAQRTSL-----------SKSYIL---YDLQEATWYELQMRVC 1551
                |:...:......|..:....:|.||           .:|.::   .||:..|.|.:.|...
 Worm  1279 ----PVAELSTNGDVIGYKLRVVPERESLMADETKVIDIPGQSTLMAKVSDLRPFTSYHVYMSAY 1339

Human  1552 NSAGCAEKQA---NFATLNYDGSTIPP--LIKSVVQNEE------------GLTTN--------- 1590
            ...|...:.:   :|.|:  :....||  ...|.:..:|            |..||         
 Worm  1340 TIVGNGPENSTPISFETM--EDVPAPPESFQCSYISEQEVRMKWLPPGSPNGKITNYIISYWKSH 1402

Human  1591 EGLKMLVTISCILVGVLLLFVLLLVVRRRRREQRLKRLRDAKSLAE----MLMSKNTR------- 1644
            |...|  .|...|:|.||:|..:.:....:....:| .|::|..:|    .:|:.:.|       
 Worm  1403 EPRSM--AIDAPLLGNLLMFAAMSLNPNTQYTFAIK-ARNSKGESEEAVAEVMTSSVRLPVRNAP 1464

Human  1645 --TSDTLSKQQQT---LRMHIDIPRAQLLIEERDTMETIDDRSTVLLTDADFGEAAKQKSLTVTH 1704
              ..||||:.|.|   :|....:||..          |.|..|.|......:.:..:.:.:|:..
 Worm  1465 APVRDTLSQHQATEIIIRWDESLPRKL----------TEDAESPVRAVQVSYQKTNEDEWITLEK 1519

Human  1705 TVHY---QSVSQATGP-------LVDVSD-----------------ARPGTNPTTRRNAKAGPTA 1742
            ...|   :||.:...|       :..:.|                 :.|...|.   :.||.|..
 Worm  1520 KFEYSKRRSVIKHLSPNSMFRFRIRFIGDFLESSWSPESEWMRTLPSAPFAQPI---SLKATPYE 1581

Human  1743 RNRYASQWTLNRPHPTISAHTLTTD---WRLPTPRAAGSVDKESDSYSVSPSQDTDRARSSMVST 1804
            ||....:|.:  ||.:    |..:|   :|:              .|...||.:|.:        
 Worm  1582 RNSVQLEWVV--PHKS----TWNSDAIGYRI--------------HYREYPSNETWQ-------- 1618

Human  1805 ESASSTYEELARAYEHAKMEEQL---------------------------------------RHA 1830
                  .||:|...||...||::                                       |:.
 Worm  1619 ------MEEIAIRDEHEDKEEKILAKLDSFKHYILRMRIFNSEGEGPFSAPVFAYVGYSIPKRNL 1677

Human  1831 KFTITE---------------------------------CFISDTSSEQ--LTAGTNEYT----- 1855
            ...|||                                 ..:|..|||:  :...|||.|     
 Worm  1678 NNIITEPLSSSSIRVKWDAWPKEDSETITSFKVRYVPVASVLSSVSSEEEIMIVDTNECTLNDLR 1742

Human  1856 ------------------------DSLTSSTPSESGICRFT--------ASPPKP-QDGGRVMNM 1887
                                    |......|...||.||:        .|..:| |..|.|:  
 Worm  1743 KFTEYQISVSPYNRAGEGKMSQVRDKTLEDKPGPVGILRFSDVLMDSVKVSWDEPSQPNGNVI-- 1805

Human  1888 AVPKAHRPGDLIHLPPYLRMDFLLNRGGPGTSR--------------------DLSLGQACLEPQ 1932
                    |.:::...|...:...|.....|||                    :.|.|:.  |.:
 Worm  1806 --------GYIVNYKGYRMQEEFKNEDQQRTSRNYFDTHGLAEGVTYFFSVWAETSAGKG--EQR 1860

Human  1933 KSRTLKRPTVLEPIPMEAASSASSTREGQSWQPGAVATLPQREGAE-------LGQAAKMSSSQE 1990
            .:.....|:...|.|    .|......|||:     .||...:.|:       |.||.::|.::|
 Worm  1861 SANVTIGPSKDGPPP----PSKPQITSGQSY-----VTLNWNDVADSDEIVGHLLQAKRVSVAEE 1916

Human  1991 -------SLLDSRGHLKGNNPYAKS 2008
                   |....|..:||    |||
 Worm  1917 APANGYVSQRPRRNEIKG----AKS 1937

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
DSCAMNP_001380.2 FN3 885..978 CDD:238020 30/104 (29%)
FN3 <937..1300 CDD:442628 108/385 (28%)
Ig_3 1287..1363 CDD:464046 17/97 (18%)
FN3 1380..1470 CDD:238020 26/95 (27%)
FN3 1486..1555 CDD:238020 14/82 (17%)
Required for netrin-mediated axon repulsion of neuronal growth cones. /evidence=ECO:0000250|UniProtKB:Q9ERC8 1617..2012 103/584 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1718..1810 18/111 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1855..1883 10/65 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1971..2012 14/52 (27%)
Ig 26..121 CDD:472250
Ig strand B 42..46 CDD:409353
Ig strand C 55..59 CDD:409353
Ig strand E 79..83 CDD:409353
Ig strand F 99..104 CDD:409353
Ig strand G 112..116 CDD:409353
Ig 125..210 CDD:472250 18/81 (22%)
Ig strand B 141..145 CDD:409353 0/3 (0%)
Ig strand C 157..161 CDD:409353 0/3 (0%)
Ig strand E 179..183 CDD:409353 1/3 (33%)
Ig strand F 192..199 CDD:409353 3/6 (50%)
I-set 235..310 CDD:400151 12/82 (15%)
Ig strand B 242..246 CDD:409353 0/3 (0%)
Ig strand C 255..259 CDD:409353 1/3 (33%)
Ig strand F 290..295 CDD:409353 1/4 (25%)
Ig 313..395 CDD:472250 19/99 (19%)
Ig strand B 331..335 CDD:409353 0/3 (0%)
Ig strand C 344..348 CDD:409353 0/3 (0%)
Ig strand E 368..372 CDD:409353 1/3 (33%)
Ig strand F 382..387 CDD:409353 0/4 (0%)
Ig 406..501 CDD:472250 26/94 (28%)
Ig strand B 424..428 CDD:409353 2/3 (67%)
Ig strand C 437..441 CDD:409353 1/3 (33%)
Ig strand E 467..471 CDD:409353 1/3 (33%)
Ig strand F 481..486 CDD:409353 2/4 (50%)
Ig strand G 494..497 CDD:409353 1/2 (50%)
IgI_5_Dscam 504..593 CDD:409550 11/91 (12%)
Ig strand A 505..507 CDD:409550 1/1 (100%)
Ig strand A' 512..516 CDD:409550 0/3 (0%)
Ig strand B 519..526 CDD:409550 0/6 (0%)
Ig strand C 533..539 CDD:409550 1/5 (20%)
Ig strand C' 540..542 CDD:409550 0/1 (0%)
Ig strand D 549..553 CDD:409550 0/3 (0%)
Ig strand E 557..563 CDD:409550 0/5 (0%)
Ig strand F 571..579 CDD:409550 3/7 (43%)
Ig strand G 583..593 CDD:409550 2/12 (17%)
Ig 596..686 CDD:472250 13/91 (14%)
Ig strand B 613..617 CDD:409353 0/3 (0%)
Ig strand C 627..631 CDD:409353 0/3 (0%)
Ig strand E 652..656 CDD:409353 2/3 (67%)
Ig strand F 666..671 CDD:409353 0/4 (0%)
Ig strand G 679..682 CDD:409353 0/2 (0%)
Ig_DSCAM 689..784 CDD:409397 25/101 (25%)
putative Ig strand A 689..693 CDD:409397 1/3 (33%)
putative Ig strand A' 698..702 CDD:409397 0/3 (0%)
putative Ig strand B 704..714 CDD:409397 1/9 (11%)
putative Ig strand C 720..726 CDD:409397 2/5 (40%)
putative Ig strand C' 733..736 CDD:409397 0/2 (0%)
putative Ig strand D 744..747 CDD:409397 1/8 (13%)
putative Ig strand E 749..755 CDD:409397 2/5 (40%)
putative Ig strand F 762..770 CDD:409397 3/7 (43%)
putative Ig strand G 775..784 CDD:409397 1/8 (13%)
Ig_DSCAM 785..884 CDD:409398 20/104 (19%)
putative Ig strand A 785..788 CDD:409398 0/2 (0%)
putative Ig strand A' 796..800 CDD:409398 0/3 (0%)
putative Ig strand B 803..810 CDD:409398 2/6 (33%)
putative Ig strand C 818..824 CDD:409398 2/5 (40%)
putative Ig strand C' 833..836 CDD:409398 0/2 (0%)
putative Ig strand D 842..846 CDD:409398 1/3 (33%)
putative Ig strand E 848..854 CDD:409398 1/5 (20%)
putative Ig strand F 861..869 CDD:409398 2/7 (29%)
putative Ig strand G 872..882 CDD:409398 2/9 (22%)
rig-4NP_501339.2 IG_like 330..402 CDD:214653 29/132 (22%)
Ig strand B 341..345 CDD:409568 2/3 (67%)
Ig strand C 354..358 CDD:409568 2/10 (20%)
Ig strand E 369..373 CDD:409568 2/7 (29%)
Ig strand F 383..388 CDD:409568 2/4 (50%)
Ig strand G 396..399 CDD:409568 2/12 (17%)
Ig 459..543 CDD:472250 25/106 (24%)
Ig strand B 476..480 CDD:409353 0/3 (0%)
Ig strand C 489..493 CDD:409353 2/17 (12%)
Ig strand E 511..515 CDD:409353 1/3 (33%)
Ig strand F 525..530 CDD:409353 2/4 (50%)
Ig strand G 536..539 CDD:409353 0/2 (0%)
IG_like 553..639 CDD:214653 19/93 (20%)
Ig strand B 564..568 CDD:409353 1/3 (33%)
Ig strand C 579..583 CDD:409353 1/3 (33%)
Ig strand E 605..609 CDD:409353 1/3 (33%)
FN3 <614..>874 CDD:442628 74/266 (28%)
Ig strand F 619..624 CDD:409353 1/4 (25%)
FN3 756..850 CDD:238020 29/97 (30%)
FN3 858..954 CDD:238020 25/102 (25%)
fn3 965..1042 CDD:394996 22/76 (29%)
FN3 1057..1151 CDD:238020 18/98 (18%)
FN3 1156..1251 CDD:238020 26/95 (27%)
FN3 <1218..>1470 CDD:442628 48/263 (18%)
FN3 1464..1560 CDD:238020 19/105 (18%)
FN3 1572..1664 CDD:238020 23/128 (18%)
FN3 <1645..>1896 CDD:442628 41/271 (15%)
FN3 1774..1858 CDD:238020 18/95 (19%)
Blue background indicates that the domain is not in the aligned region.

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