Protein Alignment DSCAM and Dscam

DIOPT Version :10

• Sequence 1: NP_001380.2
• Gene: DSCAM / 1826
• HGNCID: 3039
• Length: 2012
• Species: Homo sapiens
• Sequence 2: XP_038943864.1
• Gene: Dscam / 171119
• RGDID: 619992
• Length: 2034
• Species: Rattus norvegicus
• Alignment Length: 2034
• Identity: 1980/2034 - (97%)
• Similarity: 1999/2034 - (98%)
• Gaps: 22/2034 - (1%)

Human     1 MWILALSLFQSFANVFSEDLHSSLYFVNASLQEVVFASTTGTLVPCPAAGIPPVTLRWYLATGEE 65
            ||||||||||||||||||:.|||||||||||||||||||:|||||||||||||||||||||||||
  Rat     1 MWILALSLFQSFANVFSEEPHSSLYFVNASLQEVVFASTSGTLVPCPAAGIPPVTLRWYLATGEE 65

Human    66 IYDVPGIRHVHPNGTLQIFPFPPSSFSTLIHDNTYYCTAENPSGKIRSQDVHIKAVLREPYTVRV 130
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat    66 IYDVPGIRHVHPNGTLQIFPFPPSSFSTLIHDNTYYCTAENPSGKIRSQDVHIKAVLREPYTVRV 130

Human   131 EDQKTMRGNVAVFKCIIPSSVEAYITVVSWEKDTVSLVSGSRFLITSTGALYIKDVQNEDGLYNY 195
            ||||||||||||||||||||||||:||||||||||||||||||||||||||||||||||||||||
  Rat   131 EDQKTMRGNVAVFKCIIPSSVEAYVTVVSWEKDTVSLVSGSRFLITSTGALYIKDVQNEDGLYNY 195

Human   196 RCITRHRYTGETRQSNSARLFVSDPANSAPSILDGFDHRKAMAGQRVELPCKALGHPEPDYRWLK 260
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   196 RCITRHRYTGETRQSNSARLFVSDPANSAPSILDGFDHRKAMAGQRVELPCKALGHPEPDYRWLK 260

Human   261 DNMPLELSGRFQKTVTGLLIENIRPSDSGSYVCEVSNRYGTAKVIGRLYVKQPLKATISPRKVKS 325
            ||||||||||||||||||||||.||||||||||||||||||||||||||||||||||||||||||
  Rat   261 DNMPLELSGRFQKTVTGLLIENSRPSDSGSYVCEVSNRYGTAKVIGRLYVKQPLKATISPRKVKS 325

Human   326 SVGSQVSLSCSVTGTEDQELSWYRNGEILNPGKNVRITGINHENLIMDHMVKSDGGAYQCFVRKD 390
            ||||||||||||||.||||||||||||||||||||||||:||.||||||||||||||||||||||
  Rat   326 SVGSQVSLSCSVTGNEDQELSWYRNGEILNPGKNVRITGLNHANLIMDHMVKSDGGAYQCFVRKD 390

Human   391 KLSAQDYVQVVLEDGTPKIISAFSEKVVSPAEPVSLMCNVKGTPLPTITWTLDDDPILKGGSHRI 455
            ||||||||||||||||||||||||||||||||||||:||||||||||:||||||||||||..|||
  Rat   391 KLSAQDYVQVVLEDGTPKIISAFSEKVVSPAEPVSLVCNVKGTPLPTVTWTLDDDPILKGSGHRI 455

Human   456 SQMITSEGNVVSYLNISSSQVRDGGVYRCTANNSAGVVLYQARINVRGPASIRPMKNITAIAGRD 520
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   456 SQMITSEGNVVSYLNISSSQVRDGGVYRCTANNSAGVVLYQARINVRGPASIRPMKNITAIAGRD 520

Human   521 TYIHCRVIGYPYYSIKWYKNSNLLPFNHRQVAFENNGTLKLSDVQKEVDEGEYTCNVLVQPQLST 585
            ||||||||||||||||||||:||||||||||||||||||||||||||||||||||||||||||||
  Rat   521 TYIHCRVIGYPYYSIKWYKNANLLPFNHRQVAFENNGTLKLSDVQKEVDEGEYTCNVLVQPQLST 585

Human   586 SQSVHVTVKVPPFIQPFEFPRFSIGQRVFIPCVVVSGDLPITITWQKDGRPIPGSLGVTIDNIDF 650
            |||||||||||||||||||||||||||||||||||||||||||||||||||||.|||||||||||
  Rat   586 SQSVHVTVKVPPFIQPFEFPRFSIGQRVFIPCVVVSGDLPITITWQKDGRPIPASLGVTIDNIDF 650

Human   651 TSSLRISNLSLMHNGNYTCIARNEAAAVEHQSQLIVRVPPKFVVQPRDQDGIYGKAVILNCSAEG 715
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   651 TSSLRISNLSLMHNGNYTCIARNEAAAVEHQSQLIVRVPPKFVVQPRDQDGIYGKAVILNCSAEG 715

Human   716 YPVPTIVWKFSKGAGVPQFQPIALNGRIQVLSNGSLLIKHVVEEDSGYYLCKVSNDVGADVSKSM 780
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   716 YPVPTIVWKFSKGAGVPQFQPIALNGRIQVLSNGSLLIKHVVEEDSGYYLCKVSNDVGADVSKSM 780

Human   781 YLTVKIPAMITSYPNTTLATQGQKKEMSCTAHGEKPIIVRWEKEDRIINPEMARYLVSTKEVGEE 845
            |||||||||||||||||||||||:|||||||||||||||||||||||||||||||||||||||||
  Rat   781 YLTVKIPAMITSYPNTTLATQGQRKEMSCTAHGEKPIIVRWEKEDRIINPEMARYLVSTKEVGEE 845

Human   846 VISTLQILPTVREDSGFFSCHAINSYGEDRGIIQLTVQEPPDPPEIEIKDVKARTITLRWTMGFD 910
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   846 VISTLQILPTVREDSGFFSCHAINSYGEDRGIIQLTVQEPPDPPEIEIKDVKARTITLRWTMGFD 910

Human   911 GNSPITGYDIECKNKSDSWDSAQRTKDVSPQLNSATIIDIHPSSTYSIRMYAKNRIGKSEPSNEL 975
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||:
  Rat   911 GNSPITGYDIECKNKSDSWDSAQRTKDVSPQLNSATIIDIHPSSTYSIRMYAKNRIGKSEPSNEI 975

Human   976 TITADEAAPDGPPQEVHLEPISSQSIRVTWKAPKKHLQNGIIRGYQIGYREYSTGGNFQFNIISV 1040
            ||||||||||||||||||||.|||||||||||||||||||||||||||||||||||||||||||:
  Rat   976 TITADEAAPDGPPQEVHLEPTSSQSIRVTWKAPKKHLQNGIIRGYQIGYREYSTGGNFQFNIISI 1040

Human  1041 DTSGDSEVYTLDNLNKFTQYGLVVQACNRAGTGPSSQEIITTTLEDVPSYPPENVQAIATSPESI 1105
            ||:||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat  1041 DTTGDSEVYTLDNLNKFTQYGLVVQACNRAGTGPSSQEIITTTLEDVPSYPPENVQAIATSPESI 1105

Human  1106 SISWSTLSKEALNGILQGFRVIYWANLMDGELGEIKNITTTQPSLELDGLEKYTNYSIQVLAFTR 1170
            |||||||||||||||||||||||||||:|||||||||:|||||||||||||||||||||||||||
  Rat  1106 SISWSTLSKEALNGILQGFRVIYWANLIDGELGEIKNVTTTQPSLELDGLEKYTNYSIQVLAFTR 1170

Human  1171 AGDGVRSEQIFTRTKEDVPGPPAGVKAAAASASMVFVSWLPPLKLNGIIRKYTVFCSHPYPTVIS 1235
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat  1171 AGDGVRSEQIFTRTKEDVPGPPAGVKAAAASASMVFVSWLPPLKLNGIIRKYTVFCSHPYPTVIS 1235

Human  1236 EFEASPDSFSYRIPNLSRNRQYSVWVVAVTSAGRGNSSEIITVEPLAKAPARILTFSGTVTTPWM 1300
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat  1236 EFEASPDSFSYRIPNLSRNRQYSVWVVAVTSAGRGNSSEIITVEPLAKAPARILTFSGTVTTPWM 1300

Human  1301 KDIVLPCKAVGDPSPAVKWMKDSNGTPSLVTIDGRRSIFSNGSFIIRTVKAEDSGYYSCIANNNW 1365
            ||||||||||||||||||||||||||||||||||||||||||||:||||||||||||||:|||||
  Rat  1301 KDIVLPCKAVGDPSPAVKWMKDSNGTPSLVTIDGRRSIFSNGSFVIRTVKAEDSGYYSCVANNNW 1365

Human  1366 GSDEIILNLQVQVPPDQPRLTVSKTTSSSITLSWLPGDNGGSSIRGYILQYSEDNSEQWGSFPIS 1430
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat  1366 GSDEIILNLQVQVPPDQPRLTVSKTTSSSITLSWLPGDNGGSSIRGYILQYSEDNSEQWGSFPIS 1430

Human  1431 PSERSYRLENLKCGTWYKFTLTAQNGVGPGRISEIIEAKTLGKEPQFSKEQELFASINTTRVRLN 1495
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat  1431 PSERSYRLENLKCGTWYKFTLTAQNGVGPGRISEIIEAKTLGKEPQFSKEQELFASINTTRVRLN 1495

Human  1496 LIGWNDGGCPITSFTLEYRPFGTTVWTTAQRTSLSKSYILYDLQEATWYELQMRVCNSAGCAEKQ 1560
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat  1496 LIGWNDGGCPITSFTLEYRPFGTTVWTTAQRTSLSKSYILYDLQEATWYELQMRVCNSAGCAEKQ 1560

Human  1561 ANFATLNYDGSTIPPLIKSVVQNEEGLTTNEGLKMLVTISCILVGVLLLFVLLLVVRRRRREQRL 1625
            ||||||||||||||||||||||:|||||||||||:||||||||||||||||||||||||||||||
  Rat  1561 ANFATLNYDGSTIPPLIKSVVQSEEGLTTNEGLKILVTISCILVGVLLLFVLLLVVRRRRREQRL 1625

Human  1626 KRLRDAKSLAEMLMSKNTRTSDTLSKQQQTLRMHIDIPRAQLLIEERDTMETIDDRSTVLLTDAD 1690
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat  1626 KRLRDAKSLAEMLMSKNTRTSDTLSKQQQTLRMHIDIPRAQLLIEERDTMETIDDRSTVLLTDAD 1690

Human  1691 FGEAAKQKSLTVTHTVHYQSVSQATGPLVDVSDARPGTNPTTRRNAKAGPTARNRYASQWTLNRP 1755
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat  1691 FGEAAKQKSLTVTHTVHYQSVSQATGPLVDVSDARPGTNPTTRRNAKAGPTARNRYASQWTLNRP 1755

Human  1756 HPTISAHTLTTDWRLPTPRAAGSVDKESDSYSVSPSQDTDRARSSMVSTESASSTYEELARAYEH 1820
            ||||||||||||||||||||.||||||||||||||||||||||||||||||||||||||||||||
  Rat  1756 HPTISAHTLTTDWRLPTPRATGSVDKESDSYSVSPSQDTDRARSSMVSTESASSTYEELARAYEH 1820

Human  1821 AKMEEQLRHAKFTITECFISDTSSEQLTAGTNEYTDSLTSSTPSESGICRFTASPPKPQDGGRVM 1885
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||:
  Rat  1821 AKMEEQLRHAKFTITECFISDTSSEQLTAGTNEYTDSLTSSTPSESGICRFTASPPKPQDGGRVV 1885

Human  1886 NMAVPKAHRP---------------------GDLIHLPPYLRMDFLLNRGGPGTSRDLSLGQACL 1929
            ||||||||||                     |||||||||||||||||||.||||||||||||||
  Rat  1886 NMAVPKAHRPVLETRSSKSRHQLTHVPLRALGDLIHLPPYLRMDFLLNRGAPGTSRDLSLGQACL 1950

Human  1930 EPQKSRTLKRPTVLEPIPMEAASSASSTREG-QSWQPGAVATLPQREGAELGQAAKMSSSQESLL 1993
            ||||||||||||||||.||||:||.|||||| ||||.||||||||||||||||||||||||||||
  Rat  1951 EPQKSRTLKRPTVLEPTPMEASSSTSSTREGQQSWQQGAVATLPQREGAELGQAAKMSSSQESLL 2015

Human  1994 DSRGHLKGNNPYAKSYTLV 2012
            |||||||||||||||||||
  Rat  2016 DSRGHLKGNNPYAKSYTLV 2034

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DSCAM	NP_001380.2	FN3	885..978	CDD:238020	91/92 (99%)
		FN3	<937..1300	CDD:442628	356/362 (98%)
		Ig_3	1287..1363	CDD:464046	73/75 (97%)
		FN3	1380..1470	CDD:238020	89/89 (100%)
		FN3	1486..1555	CDD:238020	68/68 (100%)
		Required for netrin-mediated axon repulsion of neuronal growth cones. /evidence=ECO:0000250|UniProtKB:Q9ERC8	1617..2012		387/416 (93%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1718..1810		90/91 (99%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1855..1883		27/27 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1971..2012		40/40 (100%)
		Ig	26..121	CDD:472250	93/94 (99%)
		Ig strand B	42..46	CDD:409353	3/3 (100%)
		Ig strand C	55..59	CDD:409353	3/3 (100%)
		Ig strand E	79..83	CDD:409353	3/3 (100%)
		Ig strand F	99..104	CDD:409353	4/4 (100%)
		Ig strand G	112..116	CDD:409353	3/3 (100%)
		Ig	125..210	CDD:472250	83/84 (99%)
		Ig strand B	141..145	CDD:409353	3/3 (100%)
		Ig strand C	157..161	CDD:409353	3/3 (100%)
		Ig strand E	179..183	CDD:409353	3/3 (100%)
		Ig strand F	192..199	CDD:409353	6/6 (100%)
		I-set	235..310	CDD:400151	73/74 (99%)
		Ig strand B	242..246	CDD:409353	3/3 (100%)
		Ig strand C	255..259	CDD:409353	3/3 (100%)
		Ig strand F	290..295	CDD:409353	4/4 (100%)
		Ig	313..395	CDD:472250	78/81 (96%)
		Ig strand B	331..335	CDD:409353	3/3 (100%)
		Ig strand C	344..348	CDD:409353	3/3 (100%)
		Ig strand E	368..372	CDD:409353	2/3 (67%)
		Ig strand F	382..387	CDD:409353	4/4 (100%)
		Ig	406..501	CDD:472250	90/94 (96%)
		Ig strand B	424..428	CDD:409353	3/3 (100%)
		Ig strand C	437..441	CDD:409353	2/3 (67%)
		Ig strand E	467..471	CDD:409353	3/3 (100%)
		Ig strand F	481..486	CDD:409353	4/4 (100%)
		Ig strand G	494..497	CDD:409353	2/2 (100%)
		IgI_5_Dscam	504..593	CDD:409550	87/88 (99%)
		Ig strand A	505..507	CDD:409550	1/1 (100%)
		Ig strand A'	512..516	CDD:409550	3/3 (100%)
		Ig strand B	519..526	CDD:409550	6/6 (100%)
		Ig strand C	533..539	CDD:409550	5/5 (100%)
		Ig strand C'	540..542	CDD:409550	1/1 (100%)
		Ig strand D	549..553	CDD:409550	3/3 (100%)
		Ig strand E	557..563	CDD:409550	5/5 (100%)
		Ig strand F	571..579	CDD:409550	7/7 (100%)
		Ig strand G	583..593	CDD:409550	9/9 (100%)
		Ig	596..686	CDD:472250	88/89 (99%)
		Ig strand B	613..617	CDD:409353	3/3 (100%)
		Ig strand C	627..631	CDD:409353	3/3 (100%)
		Ig strand E	652..656	CDD:409353	3/3 (100%)
		Ig strand F	666..671	CDD:409353	4/4 (100%)
		Ig strand G	679..682	CDD:409353	2/2 (100%)
		Ig_DSCAM	689..784	CDD:409397	94/94 (100%)
		putative Ig strand A	689..693	CDD:409397	3/3 (100%)
		putative Ig strand A'	698..702	CDD:409397	3/3 (100%)
		putative Ig strand B	704..714	CDD:409397	9/9 (100%)
		putative Ig strand C	720..726	CDD:409397	5/5 (100%)
		putative Ig strand C'	733..736	CDD:409397	2/2 (100%)
		putative Ig strand D	744..747	CDD:409397	2/2 (100%)
		putative Ig strand E	749..755	CDD:409397	5/5 (100%)
		putative Ig strand F	762..770	CDD:409397	7/7 (100%)
		putative Ig strand G	775..784	CDD:409397	8/8 (100%)
		Ig_DSCAM	785..884	CDD:409398	97/98 (99%)
		putative Ig strand A	785..788	CDD:409398	2/2 (100%)
		putative Ig strand A'	796..800	CDD:409398	3/3 (100%)
putative Ig strand B	803..810	CDD:409398	5/6 (83%)
putative Ig strand C	818..824	CDD:409398	5/5 (100%)
putative Ig strand C'	833..836	CDD:409398	2/2 (100%)
putative Ig strand D	842..846	CDD:409398	3/3 (100%)
putative Ig strand E	848..854	CDD:409398	5/5 (100%)
putative Ig strand F	861..869	CDD:409398	7/7 (100%)
putative Ig strand G	872..882	CDD:409398	9/9 (100%)
Dscam	XP_038943864.1	Ig	26..121	CDD:472250	93/94 (99%)
		Ig strand B	42..46	CDD:409547	3/3 (100%)
		Ig strand C	55..59	CDD:409547	3/3 (100%)
		Ig strand E	79..83	CDD:409547	3/3 (100%)
		Ig strand F	99..104	CDD:409547	4/4 (100%)
		Ig strand G	112..116	CDD:409547	3/3 (100%)
		Ig	125..210	CDD:472250	83/84 (99%)
		Ig strand B	141..145	CDD:409353	3/3 (100%)
		Ig strand C	157..161	CDD:409353	3/3 (100%)
		Ig strand E	179..183	CDD:409353	3/3 (100%)
		Ig strand F	192..199	CDD:409353	6/6 (100%)
		Ig	235..310	CDD:472250	73/74 (99%)
		Ig strand B	242..246	CDD:409353	3/3 (100%)
		Ig strand C	255..259	CDD:409353	3/3 (100%)
		Ig strand F	290..295	CDD:409353	4/4 (100%)
		Ig	313..395	CDD:472250	78/81 (96%)
		Ig strand B	331..335	CDD:409353	3/3 (100%)
		Ig strand C	344..348	CDD:409353	3/3 (100%)
		Ig strand E	368..372	CDD:409353	2/3 (67%)
		Ig strand F	382..387	CDD:409353	4/4 (100%)
		Ig	406..501	CDD:472250	90/94 (96%)
		Ig strand B	424..428	CDD:409353	3/3 (100%)
		Ig strand C	437..441	CDD:409353	2/3 (67%)
		Ig strand E	467..471	CDD:409353	3/3 (100%)
		Ig strand F	481..486	CDD:409353	4/4 (100%)
		Ig strand G	494..497	CDD:409353	2/2 (100%)
		Ig	504..593	CDD:472250	87/88 (99%)
		Ig strand B	521..525	CDD:409353	3/3 (100%)
		Ig strand C	534..538	CDD:409353	3/3 (100%)
		Ig strand E	557..561	CDD:409353	3/3 (100%)
		Ig strand F	572..577	CDD:409353	4/4 (100%)
		Ig strand G	586..589	CDD:409353	2/2 (100%)
		Ig	596..686	CDD:472250	88/89 (99%)
		Ig strand B	613..617	CDD:409353	3/3 (100%)
		Ig strand C	627..631	CDD:409353	3/3 (100%)
		Ig strand E	652..656	CDD:409353	3/3 (100%)
		Ig strand F	666..671	CDD:409353	4/4 (100%)
		Ig strand G	679..682	CDD:409353	2/2 (100%)
		Ig_DSCAM	689..784	CDD:409397	94/94 (100%)
		putative Ig strand A	689..693	CDD:409397	3/3 (100%)
		putative Ig strand A'	698..702	CDD:409397	3/3 (100%)
		putative Ig strand B	704..714	CDD:409397	9/9 (100%)
		putative Ig strand C	720..726	CDD:409397	5/5 (100%)
		putative Ig strand C'	733..736	CDD:409397	2/2 (100%)
		putative Ig strand D	744..747	CDD:409397	2/2 (100%)
		putative Ig strand E	749..755	CDD:409397	5/5 (100%)
		putative Ig strand F	762..770	CDD:409397	7/7 (100%)
		putative Ig strand G	775..784	CDD:409397	8/8 (100%)
		Ig_DSCAM	785..884	CDD:409398	97/98 (99%)
		putative Ig strand A	785..788	CDD:409398	2/2 (100%)
		putative Ig strand A'	796..800	CDD:409398	3/3 (100%)
		putative Ig strand B	803..810	CDD:409398	5/6 (83%)
		putative Ig strand C	818..824	CDD:409398	5/5 (100%)
		putative Ig strand C'	833..836	CDD:409398	2/2 (100%)
		putative Ig strand D	842..846	CDD:409398	3/3 (100%)
		putative Ig strand E	848..854	CDD:409398	5/5 (100%)
		putative Ig strand F	861..869	CDD:409398	7/7 (100%)
		putative Ig strand G	872..882	CDD:409398	9/9 (100%)
		FN3	885..978	CDD:238020	91/92 (99%)
		FN3	<937..1300	CDD:442628	356/362 (98%)
		Ig_3	1287..1363	CDD:464046	73/75 (97%)
		FN3	1380..1470	CDD:238020	89/89 (100%)
		FN3	1486..1555	CDD:238020	68/68 (100%)