Protein Alignment Numbl and numb

DIOPT Version :10

• Sequence 1: NP_001403961.1
• Gene: Numbl / 18223
• MGIID: 894702
• Length: 608
• Species: Mus musculus
• Sequence 2: NP_523523.2
• Gene: numb / 34263
• FlyBaseID: FBgn0002973
• Length: 556
• Species: Drosophila melanogaster
• Alignment Length: 611
• Identity: 231/611 - (37%)
• Similarity: 295/611 - (48%)
• Gaps: 142/611 - (23%)

Mouse    30 SGPPETFRTESDGAGTMNKLRQSLR---RRKPAYVPEASRPHQWQADEDAVRKGTCSFPVRYLGH 91
            :|...:||........|::||:|.|   ||:...|||:|:||||||||:|||..||||.|:|||.
  Fly    26 NGKSASFRFSKKSPKKMDRLRRSFRDSFRRRKDRVPESSKPHQWQADEEAVRSATCSFSVKYLGC 90

Mouse    92 VEVEESRGMHVCEDAVKKLKAMGRKSVKSVLWVSADGLRVVDDKTKDLLVDQTIEKVSFCAPDRN 156
            |||.|||||.|||:|:|.|:...|:.|:.:|.||.||||||||:||.|:||||||||||||||||
  Fly    91 VEVFESRGMQVCEEALKVLRQSRRRPVRGLLHVSGDGLRVVDDETKGLIVDQTIEKVSFCAPDRN 155

Mouse   157 LDKAFSYICRDGTTRRWICHCFLALKDSGERLSHAVGCAFAACLERKQRREKECGVTAAFDASRT 221
            .::.|||||||||||||:||.|||.||||||||||||||||.||||||||:||||||..||...:
  Fly   156 HERGFSYICRDGTTRRWMCHGFLACKDSGERLSHAVGCAFAVCLERKQRRDKECGVTMTFDTKNS 220

Mouse   222 SFAREGSFRLSG-GGRPAEREAGDKKKAEAAAAPAVAPGPAQPGHVSPTPATTSPGEKGEAGTPV 285
            :|.|.||||... ..|.|....|..:::      ...||.|.||   |..||..|
  Fly   221 TFTRTGSFRQQTLTERLAMATVGTNERS------VDGPGSAMPG---PPAATVKP---------- 266

Mouse   286 AAGTTAAAIPRRHAPLEQLVRQGSFRGFPALSQKNSPFKRQLSLRLNELPSTLQR---------- 340
               ....||.|.||....|.||.|||.....||  ||||||:|||:|:|||...|
  Fly   267 ---FNPFAIERPHATPNMLERQSSFRLSTIGSQ--SPFKRQMSLRINDLPSNADRQRAFLTAAAG 326

Mouse   341 ---RTDFQVKGTVPEMEPPGTGDSDGINA----------LCTQISSSFA---------SAGAPAS 383
               :|..:....:.|:.|..:..:|.::|          ||.::|...:         :||...:
  Fly   327 NPMQTPLRSVSPIAEVSPAKSAGADPLSAAAVAADSVSQLCQELSQGLSLLTQTDALLAAGEDLN 391

Mouse   384 ------------------------GPPPATTGTSAWGEPSVPAAA-AFQPGHKRTPSEAERWLEE 423
                                    .||.|..      .|.|.:.. .:|..|.::||.:|:.:|.
  Fly   392 FNNNRSINQNIIAAEKQVQHVHSYAPPTAQV------TPRVASTTPTYQTLHSQSPSRSEQSIET 450

Mouse   424 VSQVAKAQQQQQQQQQQQQQQQATSVPPMPTMAPTLQPFSAPVGPFDTAAAQVAVFLPPTHMQPP 488
            .:::..|        :|.......|..|.....||   :.|.||...|.|:...
  Fly   451 STELPNA--------EQWLGHVVRSTSPAAPKRPT---YLANVGRAQTLASGTG----------- 493

Mouse   489 FVPAYPGLGYPPMPRVPVVGITPSQMVANAFCSAAQLQPQPATLLGKAGAFPPPAAPSAPGGQAR 553
               |..|.|.|..|       ..::.|||. .:|.||.|.          .|.|:...:|  .||
  Fly   494 ---AAVGGGGPDDP-------FDAEWVANV-AAAKQLSPD----------LPIPSTARSP--LAR 535

Mouse   554 PRPNGAPWPPEPAPAPAPELDPFEAQ 579
            ...|....||: |||.:     |:.|
  Fly   536 HSTNPFISPPK-APAQS-----FQVQ 555

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Numbl	NP_001403961.1	PTB_Numb	68..202	CDD:241298	100/133 (75%)
		PHA03247	<263..594	CDD:223021	90/374 (24%)
		NumbF	291..375	CDD:461874	35/106 (33%)
numb	NP_523523.2	PTB_Numb	67..201	CDD:241298	100/133 (75%)
		NumbF	269..374	CDD:461874	35/106 (33%)