DRSC/TRiP Functional Genomics Resources

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Protein Alignment Dusp8 and ssh

DIOPT Version :10

Sequence 1:NP_032774.1 Gene:Dusp8 / 18218 MGIID:106626 Length:663 Species:Mus musculus
Sequence 2:NP_733063.1 Gene:ssh / 42986 FlyBaseID:FBgn0029157 Length:1193 Species:Drosophila melanogaster


Alignment Length:686 Identity:148/686 - (21%)
Similarity:218/686 - (31%) Gaps:273/686 - (39%)


- Green bases have known domain annotations that are detailed below.


Mouse   162 TRILPHLYLGSQKDVLNKDLMTQNGISYVLNASNSCPKPDFICESRFMRIPINDNYCEKLLPWLD 226
            |:|..|:||||:.:..|.:.:.:||:.::||.:..... .|.....:..:.:.|:....||.:.|
  Fly   386 TKIFEHVYLGSEWNASNLEELQKNGVRHILNVTREIDN-FFPGTFEYFNVRVYDDEKTNLLKYWD 449

Mouse   227 KSIEFIDKAKLSSCQVIVHCLAGISRSATIAIAYIMKTMGMSSDDAYRFVKDRRPSISPNFNFLG 291
            .:..:|.:||....:|:|||..|:||||::.|||.||........|...||.||..|.||.|||.
  Fly   450 DTFRYITRAKAEGSKVLVHCKMGVSRSASVVIAYAMKAYQWEFQQALEHVKKRRSCIKPNKNFLN 514

Mouse   292 QLLEYE------RSLKLLAALQTDGPHLGTPEPLMGPAAGIPLPRL-------PPSTSESAAT-- 341
            ||..|.      ::.:.|...:::.....|.:..:.|.:. |.|.:       ..||.|:..|  
  Fly   515 QLETYSGMLDAMKNKEKLQRSKSETNLKSTKDARLLPGSE-PTPLIQALNQAKSKSTGEAGVTPD 578

Mouse   342 GSE-----------AATAAREGSPSAGGDAPIPSTAPATSALQQGLRG----------------- 378
            |.|           |..:.|.....:...:|...||..|....|.:..                 
  Fly   579 GEEEDGSRMHRRSIAQKSQRRMVRRSSSTSPKTQTAVVTKQQSQSMENLTPERSVAEEPKNMRFP 643

Mouse   379 --------------LHLSS-------DRLQD------------------------TNRLKRS--- 395
                          ||:..       .|:.|                        |:.|.:|   
  Fly   644 GSNGENYSVTQNQVLHIQKHTPLSVRTRIHDLEAHRADQLPQQPVWTSLTKLITQTSHLGKSVSG 708

Mouse   396 -----------------FSLDIKSAYAPSRRPDFPGPPDPGEAPKLCKLDS------PSGGTLGL 437
                             ||..:.|.:|          .|.||..:..|..|      ||||.:..
  Fly   709 SSSGNIDSRRDSSCSDVFSSQVDSVFA----------KDEGEKRQRRKTHSWTESLGPSGGIVLD 763

Mouse   438 PSPSPDSPDSVPECRPRPRRRRPPASSPARSPAHGLGLN------------FGDTARQTPR---- 486
            |:|......|....|||..|:|   ..|:|..:.|.|.|            :.|:.|.|..    
  Fly   764 PTPQQQKQQSNAILRPRGTRQR---ELPSRHASWGSGDNRCCLPQRTSSGSYYDSNRNTTAIFEG 825

Mouse   487 --------------HGLSALSAPGLPGPGQPAGPGGWV--------------------------- 510
                          .|::....| :.|.|:     |.|                           
  Fly   826 VIQDLKRSSNCNVIEGVAVAVEP-IVGVGE-----GTVKRTKQKLEESTSLKKRCQEESQELLLE 884

Mouse   511 ---------PPL----DSPGTPSPDGPW-CFSPE--------------GAQGPGAVFSAFG---- 543
                     |.|    .|..:|....|. |.|.|              |......|....|    
  Fly   885 AVDAGQRRCPSLYRSASSAHSPRQRQPLRCNSEELMHTSDIENKNTTPGDHEATVVLRVQGQTLA 949

Mouse   544 ---RVSAGAPGPGN--------SSSSGGGGGGGGGGGGGGGGGGSSSSNSSSSS----------- 586
               |:|      ||        .:.:|..|.|||||||...|.||||:.::|.|           
  Fly   950 DDQRIS------GNVQILKQNFEAKAGVVGTGGGGGGGTAAGSGSSSTIATSVSAVAGACSANPG 1008

Mouse   587 ---------------------SSSSSSSSSSSSSSD 601
                                 |::|:|:||:|:|||
  Fly  1009 KKTTSHQSLPSSPVAQHANHVSAASNSNSSASNSSD 1044

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Dusp8NP_032774.1 DSP_MapKP 10..137 CDD:238723
DSP_DUSP8 150..300 CDD:350493 48/143 (34%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 313..367 14/73 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 404..624 72/336 (21%)
sshNP_733063.1 SSH-N 21..313 CDD:212166
DEK_C 326..379 CDD:462592
DSP_slingshot 385..523 CDD:350363 48/137 (35%)
Blue background indicates that the domain is not in the aligned region.

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