Protein Alignment Ntsr1 and PK2-R2

DIOPT Version :10

• Sequence 1: NP_061236.1
• Gene: Ntsr1 / 18216
• MGIID: 97386
• Length: 424
• Species: Mus musculus
• Sequence 2: NP_731788.1
• Gene: PK2-R2 / 41638
• FlyBaseID: FBgn0038139
• Length: 599
• Species: Drosophila melanogaster
• Alignment Length: 423
• Identity: 128/423 - (30%)
• Similarity: 203/423 - (47%)
• Gaps: 66/423 - (15%)

Mouse    25 FGLETMLLALS-LSNGSGNSSESI---LEPNSNLDVNTDIYSKVLVTAV---YLALFVVGTVGNS 82
            |..|..||.|: :.|.|.::..|:   |||...|...|.:....|:..:   |..:|:.|.:||.
  Fly    21 FHNEKFLLNLTQVLNISADNLTSLLQGLEPEELLPTVTPMTPLSLLATLSVGYALIFIAGVLGNL 85

Mouse    83 VTAFTLARKKSLQSLQSTVHYHLGSLALSDLLILLLAMPVELYNFIWVHHP--WAFGDAGCRGYY 145
            :|...::|.   ..:.:..:::|.:||:||:::|...||.:||| :|  ||  :.|.|:.|....
  Fly    86 ITCIVISRN---NFMHTATNFYLFNLAISDMILLCSGMPQDLYN-LW--HPDNYPFSDSICILES 144

Mouse   146 FLRDACTYATALNVASLSVERYLAICHPFKAKTLMSRSRTKKFISAIWLASALLAVP--MLFTMG 208
            .|.:....||.|.:.:.:||||:||||||:..|:...||..|||.|||:|:.|||:|  :.|::.
  Fly   145 VLSETAANATVLTITAFTVERYIAICHPFRQHTMSKLSRAVKFIFAIWIAALLLALPQAIQFSVV 209

Mouse   209 LQNRSADGQHPGGLVCTPTVDTATVKVVIQVNTFMSFLFPMLIISILNTVIANK------LTVMV 267
            :|..        |..||...|  ....|..|:.|:.|..||..|.:|..:|..|      |..:.
  Fly   210 MQGM--------GTSCTMKND--FFAHVFAVSGFLFFGGPMTAICVLYVLIGVKLKRSRLLQALP 264

Mouse   268 HQAAEQGRGVCTVGTHNSLEHSTFNMSIEPGRVQALRHGVLVLRAVVIAFVVCWLPYHVRRLMFC 332
            .:..:..||                       :.|....:.:|.||.:||.:||.|:|.:|||..
  Fly   265 RRCYDVNRG-----------------------ISAQTRVIRMLVAVAVAFFICWAPFHAQRLMAV 306

Mouse   333 YIS----DEQWTTFLFDFYHYFYMLTNALFYVSSAINPILYNLVSANFRQVFLSTLA-CLCPGWR 392
            |.|    :.||...:|....|   .:..|:::|:.|||:|||::|..||:.|..||| ....|.:
  Fly   307 YGSTSGIESQWFNDVFSILDY---TSGVLYFLSTCINPLLYNIMSHKFREAFKVTLARHFGLGGK 368

Mouse   393 RRRKKRP-TFSR-KPNSMSSNHAFSTSATRETL 423
            .:.:..| |:|. :.|...|....:|.:.|.|:
  Fly   369 NQGRGLPHTYSALRRNQTGSLRLHTTDSVRTTM 401

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ntsr1	NP_061236.1	7tmA_NTSR1	64..380	CDD:320477	102/332 (31%)
		TM helix 1	64..91	CDD:320477	7/29 (24%)
		TM helix 2	101..127	CDD:320477	10/25 (40%)
		TM helix 3	141..171	CDD:320477	10/29 (34%)
		TM helix 4	183..205	CDD:320477	13/23 (57%)
		TM helix 5	233..262	CDD:320477	9/28 (32%)
		TM helix 6	301..331	CDD:320477	12/29 (41%)
		Neurotensin binding. /evidence=ECO:0000250	326..349		8/26 (31%)
		TM helix 7	348..373	CDD:320477	9/24 (38%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	398..424		8/28 (29%)
PK2-R2	NP_731788.1	7tmA_capaR	69..355	CDD:320262	101/327 (31%)
		TM helix 1	69..94	CDD:320262	6/24 (25%)
		TM helix 2	101..127	CDD:320262	11/26 (42%)
		TM helix 3	140..170	CDD:320262	10/29 (34%)
		TM helix 4	182..204	CDD:320262	13/21 (62%)
		TM helix 5	225..253	CDD:320262	9/27 (33%)
		TM helix 6	275..305	CDD:320262	12/29 (41%)
		TM helix 7	323..348	CDD:320262	9/27 (33%)