DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DRP2 and Dys

DIOPT Version :9

Sequence 1:	NP_001930.2	Gene:	DRP2 / 1821	HGNCID:	3032	Length:	957	Species:	Homo sapiens
Sequence 2:	NP_001036722.1	Gene:	Dys / 42327	FlyBaseID:	FBgn0260003	Length:	3598	Species:	Drosophila melanogaster

Alignment Length:	913	Identity:	361/913 - (39%)
Similarity:	534/913 - (58%)	Gaps:	90/913 - (9%)

- Green bases have known domain annotations that are detailed below.

Human    52 DGAGVPCL-SLKLLNGSVGASGPLEPPAMNLCWNEIKKKSHNLRARLEAFSDHSGKLQLPLQEII 115
            ||.|...| ||.....:|.....|:  .||..||.:|.||..:|.|||:.|:|...|.|.|:|:.
  Fly  2530 DGTGRKLLGSLTSQEDAVMLQRRLD--EMNQRWNNLKSKSIAIRNRLESNSEHWNALLLSLRELT 2592

Human   116 DWLSQKDEELS--AQLPLQGDVALVQQEKETHAAFMEEVKSRGPYIYSVLESAQAFLSQH----P 174
            :|:.:||.|||  ...|::||...:|::.:.|.||..:::.:.|.:.|.|.|.:.:::..    .
  Fly  2593 EWVIRKDTELSTLGLGPVRGDAVSLQKQLDDHKAFRRQLEDKRPIVESNLTSGRQYIANEAAVSD 2657

Human   175 FEELEEPH-SESKDTSPKQRIQNLSRFVWKQATVASELWEKLTARCVDQHRHIERTLEQLLEIQG 238
            ..:.|..| |:|:..|.:::.:.|:|.:.::....||.|..|..|..:....::..:.::.:.|.
  Fly  2658 TSDTEANHDSDSRYMSAEEQSRELTRSIRREVGKLSEQWNNLIDRSDNWKHRLDEYMTKMRQFQK 2722

Human   239 AMEELSTTLSQAEGVRATWEPIGDLFIDSLPEHIQAIKLFKEEFSPMKDGVKLVND--------L 295
            .:|:||:.::.||..:.:|.|...  :....|.:|.::..:::   |.....|::|        .
  Fly  2723 ILEDLSSRVALAEQTKTSWLPPSS--VGEANEQMQQLQRLRDK---MTTASALLDDCNEQQSFFT 2782

Human   296 AHQLAISDVHLSMENSQALEQINVRWKQLQASVSERLKQL-----QDAHRD------------FG 343
            |:|:.:....||     .||.:|.|.|.||.::.||.|.|     |..|.:            .|
  Fly  2783 ANQVLVPTPCLS-----KLEDLNTRMKLLQIAMDERQKVLCQAGAQQTHENGDDGRTTSNSGTIG 2842

Human   344 PGSQHFLSSSVQVPWERAISPNKVPYYINHQAQTTCWDHPKMTELYQTLADLNNIKFSAYRTAMK 408
            |...  |..||:.|||||.:...|||||:|:.:||.||||:|.||.:.|||||.|:|||||||||
  Fly  2843 PLPN--LGQSVKPPWERATTAANVPYYIDHERETTHWDHPEMIELMKGLADLNEIRFSAYRTAMK 2905

Human   409 LRRVQKALRLDLVTLTTALEIFNEHDLQA-SEHVMDVVEVIHCLTALYERLEEERGILVNVPLCV 472
            ||.|||.|.||.::::||.|.|:.|.|:| ::.::|:.::...|.:||..:::     :::.|.:
  Fly  2906 LRSVQKRLALDRISMSTACESFDRHGLRAQNDKLIDIPDMTTVLHSLYVTIDK-----IDLTLML 2965

Human   473 DMSLNWLLNVFDSGRSGKMRALSFKTGIACLCGTEVKEKLQYLFSQVANSGSQCDQRHLGVLLHE 537
            |:::||:|||:||.|:|::|.||||.|:..||...::||.:|||..||::..:.|||.||:|||:
  Fly  2966 DLAINWILNVYDSQRTGQIRVLSFKVGLVLLCKGHLEEKYRYLFRLVADTDRRADQRRLGLLLHD 3030

Human   538 AIQVPRQLGEVAAFGGSNVEPSVRSCF-RFSTGKPVIEASQ--------FLEWVNLEPQSMVWLA 593
            .|||||||||||||||||:|||||||. :....:..|:.:|        ||.|:..||||:|||.
  Fly  3031 CIQVPRQLGEVAAFGGSNIEPSVRSCLEQAGISQEAIDGNQDISIELQHFLGWLQHEPQSLVWLP 3095

Human   594 VLHRVTIAEQVKHQTKCSICRQCPIKGFRYRSLKQFNVDICQTCFLTGRASKGNKLHYPIMEYYT 658
            ||||:..||..|||.||:||::.||.|||||.||.||.|:||.||..||.:|.:||.:|:.||.|
  Fly  3096 VLHRLAAAEAAKHQAKCNICKEYPIVGFRYRCLKCFNFDMCQKCFFFGRNAKNHKLTHPMHEYCT 3160

Human   659 PTTSSENMRDFATTLKNKFRSKHYFSKHPQRGYLPVQSVLEADYSETPASSPMWPHA------DT 717
            .|||:|::|||...|||||:|:.||.|||:.||||||||||.|..|:||.||.  |.      |.
  Fly  3161 TTTSTEDVRDFTRALKNKFKSRKYFKKHPRVGYLPVQSVLEGDALESPAPSPQ--HTTHQLQNDM 3223

Human   718 HSRIEHFASRLAEMESQNCSFFNDSLSPDDSIDEDQYLLRHSSPITDREPAFGQQAPCSVA---- 778
            |||:|.:|||||::|...    ..|.|..||.||.|.:.::...:.........::|..|.
  Fly  3224 HSRLEMYASRLAQVEYGG----TGSNSTPDSDDEHQLIAQYCQALPGTSNGSAPKSPVQVMAAMD 3284

Human   779 TESKGELQKILAHLEDENRILQGELRRLKWQHEEAAEAPSLADGSTEAATD--------HRNEEL 835
            .|.:.||:.|:..||:||..||.|.::|  ..:|.:..|..::|...:::.        .:.:::
  Fly  3285 AEQREELEAIIRDLEEENANLQAEYQQL--CSKEQSGMPEDSNGMQHSSSSMTGLSGQGEQGQDM 3347

Human   836 LAEARILRQHKSRLETRMQILEDHNKQLESQLQRLRELLLQPPTESDGSGSAGSSLASSPQQSEG 900
            :|||::|||||.|||.|||||||||:|||:||||||:||.:|  ...||.:..|.|.|:|..:..
  Fly  3348 MAEAKLLRQHKGRLEARMQILEDHNRQLEAQLQRLRQLLDEP--NGGGSSATSSGLPSAPGSALN 3410

Human   901 SHP 903
            |.|
  Fly  3411 SKP 3413

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DRP2	NP_001930.2	Spectrin 1	102..179		22/82 (27%)
		SPEC	111..339	CDD:238103	60/247 (24%)
		Spectrin 2	231..337		28/118 (24%)
		WW	357..385	CDD:238122	17/27 (63%)
		EF-hand_2	386..504	CDD:286194	53/118 (45%)
		EF-hand_3	508..599	CDD:286195	55/99 (56%)
		ZZ_dystrophin	608..656	CDD:239074	26/47 (55%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	877..923		9/27 (33%)
Dys	NP_001036722.1	CH	13..111	CDD:278723
		CH	129..225	CDD:278723
		SPEC	312..525	CDD:238103
		SbcC	<325..957	CDD:223496
		Smc	<816..1591	CDD:224117
		SPEC	1174..1365	CDD:238103
		SPEC	1289..1485	CDD:295325
		SPEC	2369..2576	CDD:238103	18/47 (38%)
		SPEC	2477..2714	CDD:238103	54/185 (29%)
		WW	2852..2882	CDD:238122	17/29 (59%)
		EF-hand_2	2883..2997	CDD:286194	53/118 (45%)
		EF-hand_3	3001..3100	CDD:286195	54/98 (55%)
		ZZ_dystrophin	3110..3158	CDD:239074	26/47 (55%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	127	1.000	Domainoid score	I5363
eggNOG	1	0.900	-	-		E2759_KOG4286
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D46278at33208
OrthoFinder	1	1.000	-	-		FOG0001792
OrthoInspector	1	1.000	-	-		otm42057
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4540
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.850