DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment JAG1 and crb

DIOPT Version :10

Sequence 1:NP_000205.1 Gene:JAG1 / 182 HGNCID:6188 Length:1218 Species:Homo sapiens
Sequence 2:NP_001247284.1 Gene:crb / 42896 FlyBaseID:FBgn0259685 Length:2253 Species:Drosophila melanogaster


Alignment Length:1238 Identity:326/1238 - (26%)
Similarity:469/1238 - (37%) Gaps:409/1238 - (33%)


- Green bases have known domain annotations that are detailed below.


Human    93 SFGSGST--------PVIGGNTFNLKASRGND-------RNRIV-------LPFSFAWPR----- 130
            ::.:|||        |:...:..:.::.||.:       :|.||       |..|.|.|.     
  Fly    91 AYFNGSTYLRLTTPMPIWDHSAISFRSCRGGEILAQQYNKNSIVISVLNDFLQISLAGPAVHGPN 155

Human   131 -------SYTLLVEAWD--------------------------------SSNDTVQPDSI-IEKA 155
                   .|.||...|.                                ::.|....|:| |...
  Fly   156 NRLDVKLPYQLLDNRWHTLQFKYEYGNLYLHVDRAASIFANSTYNSQFLTNQDIGYKDAILILGN 220

Human   156 SHSGMI--NPSRQW--QTLKQNTGVAHFEYQIRVT---CDDYYYGFGCNKFCRPRDDFFGHYACD 213
            |.||.:  .|..|:  .:..||....|    ..:|   |.|:      :.|.|..|:|     | 
  Fly   221 SFSGCLLDGPGLQFVNNSTVQNVVFGH----CPLTPGPCSDH------DLFTRLPDNF-----C- 269

Human   214 QNGNKTCMEGWMGPECNRAICRQGCSPKHGSCKLPG---DCRCQYGWQGLYCDK-----CIPHPG 270
              .|..||                   .||:|....   :|||...:.|..|.|     |..:|.
  Fly   270 --LNDPCM-------------------GHGTCSSSPEGYECRCTARYSGKNCQKDNGSPCAKNPC 313

Human   271 CVHGICNE----PWQCLCETNWGGQLCDKDLN---YCGTHQPCLNGGTCSNT-GPDKYQCSCPEG 327
            ...|.|.|    .:||.|:.|..||.|:.::|   .|.|: ||||.|.|... |.....|.||:|
  Fly   314 ENGGSCLENSRGDYQCFCDPNHSGQHCETEVNIHPLCQTN-PCLNNGACVVIGGSGALTCECPKG 377

Human   328 YSGPNCEIAEHACLSDPCHNRGSCKETSLGFECECS-PGWTGPTCSTNIDDCSPN---------- 381
            |:|..||:....|.|.||.|.|||.:...||.|:|| .|:||..|.||:|:|..|          
  Fly   378 YAGARCEVDTDECASQPCQNNGSCIDRINGFSCDCSGTGYTGAFCQTNVDECDKNPCLNGGRCFD 442

Human   382 ---------------------------NCSHGGTCQDLVNGFKCVCPPQWTGKTCQL-------- 411
                                       .|.:||||.|...||:|:|||::||:.||:        
  Fly   443 TYGWYTCQCLDGWGGEICDRPMTCQTQQCLNGGTCLDKPIGFQCLCPPEYTGELCQIAPSCAQQC 507

Human   412 ----------------------------------------------------------------- 411
                                                                             
  Fly   508 PIDSECVGGKCVCKPGSSGPIGHCLPTTTTPTPEQEPTTTPRTTPNPNPAIPNTLTTTTKIPPIT 572

Human   412 ----------------------------DANECEAKPCVNAKSCKNLIASYYCDCLPGWMGQNCD 448
                                        ..|.|..:.|:|..:|.....:|.|.|..|:.|.||.
  Fly   573 TSRTLVGTTTGSRRPPQQPLQSPTQRSASLNACPQENCLNGGTCLGYSGNYSCICASGYTGYNCQ 637

Human   449 --------------ININDCLGQCQNDASCRDLVNGYRCICPPGYAGDHCERDIDECASNPCLNG 499
                          ||.|...|:|.|..:|.  :||..|.|..||:||.||: .:.|:...|...
  Fly   638 TSTGDGASALALTPINCNATNGKCLNGGTCS--MNGTHCYCAVGYSGDRCEK-AENCSPLNCQEP 699

Human   500 GHC-QNEINRFQCLCPTGFSGNLCQLDIDYCEPNPCQNGAQCYNRAS-DYFCKCPEDYEGKNCSH 562
            ..| ||     |||||   ...:|    :.|...|||||.:|.:..: ||.|||...:.|:.|.:
  Fly   700 MVCVQN-----QCLCP---ENKVC----NQCATQPCQNGGECVDLPNGDYECKCTRGWTGRTCGN 752

Human   563 LKDHCRTTPCEVIDSCTVAMASNDTPEGVRYISSNVCGPHGKCKSQSGGKFTCDCNKGFTGTYCH 627
            ..|.|...|                         .:|| :|.||::. |.:.|.|..||||.:|.
  Fly   753 DVDECTLHP-------------------------KICG-NGICKNEK-GSYKCYCTPGFTGVHCD 790

Human   628 ENINDCESNPCRNGGTCIDGVNSYKCICSDGWEGAYCETNINDCSQNPCHNGGTCRDLVNDFYCD 692
            .::::|.|.||.||.||.:.:|:|:|:|..|:||..||.:|::|..|||.||.||.|.:|:|.|:
  Fly   791 SDVDECLSFPCLNGATCHNKINAYECVCQPGYEGENCEVDIDECGSNPCSNGSTCIDRINNFTCN 855

Human   693 CKNGWKGKTCHSRDSQCDEATCNNGGTCYDEGDAFKCMCPG-GWEGTTCNIARNSSCLPNPCHNG 756
            |..|..|:.|......|....|.|||.|.|:...|:|.|.| |:||..|.: ....||.|||.||
  Fly   856 CIPGMTGRICDIDIDDCVGDPCLNGGQCIDQLGGFRCDCSGTGYEGENCEL-NIDECLSNPCTNG 919

Human   757 GTCVVNGESFTCVCKEGWEGPICAQNTNDCSPHPCYNSGTCVDGDN------------------- 802
            ..|:...:.:.|.|..|::|..|.|:.|:|..:||..:|.|::..|                   
  Fly   920 AKCLDRVKDYFCDCHNGYKGKNCEQDINECESNPCQYNGNCLERSNITLYQMSRITDLPKVFSQP 984

Human   803 -------WYRCECAPGFAGPDCRININECQSSPCAFGATCVDEINGYRCVCPPGHSGAKCQEVS- 859
                   .|.|.|.||..|.:|.||||||.|:||:....|.|.|..|.|.|.||..|..| |:: 
  Fly   985 FSFENASGYECVCVPGIIGKNCEININECDSNPCSKHGNCNDGIGTYTCECEPGFEGTHC-EINI 1048

Human   860 -----GRPCITMGSVIPDGAKWDD----DCNTCQCLNGRIACSKV--WCGPRPCLLHKGHSECPS 913
                 ..||       ..|..:|.    ||: |....|...||.:  .|...|||         :
  Fly  1049 DECDRYNPC-------QRGTCYDQIDDYDCD-CDANYGGKNCSVLLKGCDQNPCL---------N 1096

Human   914 GQSCIP-ILDDQCFVHPCTGVG-----EC-RSSSLQPVKTKCTSDSYYQDNCANITFTFNKEM-- 969
            |.:|:| ::::...::.||...     :| ::::|..|.|...|.:..::...:|...|...:  
  Fly  1097 GGACLPYLINEVTHLYNCTCENGFQGDKCEKTTTLSMVATSLISVTTEREEGYDINLQFRTTLPN 1161

Human   970 --MSPGLTTE-----HICSELRN--LNILKNVSAEY-SIYIACEPSPS-------ANNEIHVAIS 1017
              ::.|.|.|     ....||.|  ||:..::..:: .::|..:.:.|       |.|..|:.:|
  Fly  1162 GVLAFGTTGEKNEPVSYILELINGRLNLHSSLLNKWEGVFIGSKLNDSNWHKVFVAINTSHLVLS 1226

Human  1018 AED 1020
            |.|
  Fly  1227 AND 1229

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
JAG1NP_000205.1 MNNL 32..185 CDD:462222 29/162 (18%)
DSL 167..229 CDD:128366 14/66 (21%)
Important for interaction with NOTCH1. /evidence=ECO:0000269|PubMed:18660822 199..207 3/7 (43%)
EGF_CA 296..334 CDD:238011 16/41 (39%)
EGF 340..370 CDD:394967 16/30 (53%)
EGF_CA 374..410 CDD:238011 18/72 (25%)
EGF_CA 412..447 CDD:238011 10/34 (29%)
EGF_CA 450..485 CDD:238011 14/34 (41%)
EGF_CA 487..523 CDD:238011 10/36 (28%)
EGF_CA 525..560 CDD:238011 13/35 (37%)
EGF_CA 629..665 CDD:238011 15/35 (43%)
EGF_CA 667..702 CDD:238011 16/34 (47%)
EGF 748..777 CDD:394967 11/28 (39%)
EGF_CA 782..817 CDD:238011 13/60 (22%)
EGF_CA 820..856 CDD:238011 17/35 (49%)
VWC_out 863..930 CDD:214565 16/73 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1152..1218
crbNP_001247284.1 LamG 91..228 CDD:238058 24/136 (18%)
EGF 269..299 CDD:394967 11/51 (22%)
EGF_CA <311..341 CDD:238011 10/29 (34%)
EGF_CA 386..423 CDD:238011 16/36 (44%)
EGF_CA 425..460 CDD:238011 4/34 (12%)
EGF 466..495 CDD:394967 13/28 (46%)
EGF 605..633 CDD:394967 8/27 (30%)
EGF_CA 716..750 CDD:238011 13/33 (39%)
EGF_CA 753..789 CDD:238011 15/62 (24%)
EGF_CA 792..828 CDD:238011 15/35 (43%)
EGF_CA 830..865 CDD:238011 16/34 (47%)
EGF_CA 868..905 CDD:238011 14/36 (39%)
EGF_CA 907..943 CDD:238011 12/35 (34%)
EGF_CA 1009..1045 CDD:238011 18/36 (50%)
EGF_CA 1047..1082 CDD:238011 8/42 (19%)
Laminin_G_1 1155..1290 CDD:395008 17/75 (23%)
EGF 1316..1346 CDD:394967
Laminin_G_1 1388..1550 CDD:395008
EGF_CA <1593..1622 CDD:238011
Laminin_G_2 1692..1828 CDD:460494
EGF_CA 1901..1937 CDD:238011
EGF_CA 1939..1974 CDD:238011
EGF_CA 2057..2094 CDD:238011
EGF_CA 2096..2133 CDD:238011
EGF_CA 2137..2175 CDD:238011
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.