DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment JAG1 and dsl-4

DIOPT Version :9

Sequence 1:	NP_000205.1	Gene:	JAG1 / 182	HGNCID:	6188	Length:	1218	Species:	Homo sapiens
Sequence 2:	NP_001359594.1	Gene:	dsl-4 / 184563	WormBaseID:	WBGene00001106	Length:	368	Species:	Caenorhabditis elegans

Alignment Length:	264	Identity:	84/264 - (31%)
Similarity:	114/264 - (43%)	Gaps:	39/264 - (14%)

- Green bases have known domain annotations that are detailed below.

Human   172 QNTGVAHFEYQIRVTCDDYYYGFGCNKFCRPRDDFFGHYACDQNGNKTCMEGWMGPECNRAICRQ 236
            :|....||  .:|..||:.:....|:.||:.|.|  ..:.||.:....|..|:.||.|::..|..
Worm   113 KNDSFLHF--AVRNVCDENWRTHSCSIFCKDRSD--SKFKCDDDDGYKCAPGYSGPNCDKVDCPF 173

Human   237 GCSPKHGSCKLPGDCRCQYGWQGLYCDKCIPHPGCVHG--ICNE----PWQCLCETNWGGQLCDK 295
            .|. .||||::||.|.|..|:.|.||:.|.|...|.||  :.||    |:.|.|...:.|...||
Worm   174 NCH-NHGSCEVPGKCMCSQGFFGTYCEYCKPSTTCKHGAVLVNELGCHPYTCRCFEGYAGDNGDK 237

Human   296 DLNYCGTHQPCLNGGTCSN-TGPDKYQCSCPEGYSGPNCE--IAEHACLSDP--CHNRGSCKETS 355
            | :.|...:||.:|...|| |....::|.||:.:.|..||  ||...| ||.  |.|:|.|....
Worm   238 D-DVCYYAKPCRHGNCVSNVTVSGGFECICPKAFGGRRCEKRIARWDC-SDEGYCQNKGVCSFVD 300

Human   356 LGFECECSPGWTGPTCS-TNIDDCSPNNCSHGGTCQDLVNGFKCVCPPQWTGKTCQLDANECEAK 419
            ....|.|:.|:||..|. .....|....|.         .||.|:...:.||           ..
Worm   301 GISRCRCAVGFTGKHCERKTAKTCLKKKCR---------EGFICIIDNKKTG-----------TM 345

Human   420 PCVN 423
            ||.|
Worm   346 PCFN 349

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
JAG1	NP_000205.1	MNNL	32..106	CDD:284966
		DSL	167..229	CDD:279722	17/56 (30%)
		Important for interaction with NOTCH1. /evidence=ECO:0000269\|PubMed:18660822	199..207		4/7 (57%)
		EGF_CA	296..334	CDD:238011	12/38 (32%)
		EGF	340..370	CDD:278437	12/31 (39%)
		EGF_CA	374..410	CDD:238011	7/35 (20%)
		EGF_CA	412..447	CDD:238011	3/12 (25%)
		EGF_CA	450..485	CDD:238011
		EGF_CA	487..523	CDD:238011
		EGF_CA	525..560	CDD:238011
		EGF_CA	629..665	CDD:238011
		EGF_CA	667..702	CDD:238011
		EGF	748..777	CDD:278437
		EGF_CA	782..817	CDD:238011
		EGF_CA	820..856	CDD:238011
		VWC_out	863..930	CDD:214565
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1152..1218
dsl-4	NP_001359594.1	DSL	110..166	CDD:366627	17/56 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	49	1.000	Domainoid score	I8699
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D197806at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.920